Dnmt1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt1
DNA methyltransferase 1
MGI:94912

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
A^vy/A Dnmt1^MommeD2/Dnmt1⁺ involves: C57BL/6J * FVB/NJ	yellow coat color	J:99816
Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺ involves: 129S4/SvJae * C57BL/6J	intestine polyps	J:75230
Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1^tm1Pwl involves: 129S4/SvJae * C57BL/6J	normal digestive/alimentary phenotype	J:75230
Apc^Min/Apc⁺ Dnmt1^tm1Pwl/Dnmt1⁺ involves: 129S4/SvJae * C57BL/6J	intestine polyps	J:75230
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Dnmt1^tm2Jae/Dnmt1⁺ Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	anemia	J:196140
	decreased erythrocyte cell number	J:196140
Dmap1^tm1.2Jrc/Dmap1⁺ Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	abnormal DNA methylation	J:172814
	transmission ratio distortion	J:172814
Dmap1^tm1.2Jrc/Dmap1^tm1.2Jrc Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	embryonic lethality before implantation, complete penetrance	J:172814
Dnmt1^{tm1(tetO-BCL2)Sjk}/Dnmt1⁺ Tg(IghMyc)22Bri/0 Tg(MMTVtTA)1Mam/0 involves: 129S4/SvJae * C57BL/6	enlarged spleen	J:93549
	increased B cell derived lymphoma incidence	J:93549
	increased leukemia incidence	J:93549
	lethargy	J:93549
	premature death	J:93549
Dnmt1^tm1Enl/Dnmt1^tm1Enl H19^tm1Tilg/H19⁺ involves: 129S/SvEv * 129S4/SvJae	genetic imprinting	J:110857
Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Dnmt1^tm1Jae/Dnmt1^tm1Pwl Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased lymphoma incidence	J:75745
	normal neoplasm	J:75745
	premature death	J:75745
Dnmt1^tm1Pwl/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Dnmt1^tm3Jae/Dnmt1^tm2Enl involves: 129S4/SvJae * BALB/c	increased tumor incidence	J:82979
	postnatal growth retardation	J:82979
	normal reproductive system phenotype	J:82979
Dnmt1^tm3Jae/Dnmt1^tm3Jae involves: 129S4/SvJae * BALB/c	no abnormal phenotype detected	J:83179

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24