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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Edn1
endothelin 1
MGI:95283
53 phenotypes from 3 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Edn1tm1.1Ywa/Edn1+
involves: 129S6/SvEvTac 		normal cardiovascular system phenotype J:196635
Edn1tm1.1Ywa/Edn1tm1.1Ywa
involves: 129S6/SvEvTac 		abnormal cardiovascular system morphology J:196635
abnormal craniofacial morphology J:196635
neonatal lethality, complete penetrance J:196635
Edn1tm1Utj/Edn1+
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR) 		increased systemic arterial blood pressure J:17694
Edn1tm1Utj/Edn1+
involves: 129X1/SvJ * ICR 		abnormal blood gas level J:60070
abnormal sympathetic nervous system physiology J:60070
hypercapnia J:60070
hypoxia J:60070
increased mean systemic arterial blood pressure J:60070
Edn1tm1Utj/Edn1tm1Utj
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR) 		abnormal first pharyngeal arch morphology J:17694
abnormal hyoid bone morphology J:17694
abnormal Meckel's cartilage morphology J:17694
abnormal middle ear morphology J:17694
abnormal neck muscle morphology J:17694
abnormal tongue morphology J:17694
abnormal tongue muscle morphology J:17694
absent hyoid bone J:17694
absent outer ear J:17694
absent submandibular gland J:17694
cleft chin J:17694
cleft palate J:17694
mandible hypoplasia J:17694
perinatal lethality, complete penetrance J:17694
small second pharyngeal arch J:17694
Edn1tm1Utj/Edn1tm1Utj
involves: 129X1/SvJ * ICR 		abnormal aorta morphology J:26778
abnormal cardiovascular system morphology J:26778
abnormal carotid artery morphology J:26778
abnormal fourth pharyngeal arch artery morphology J:26778
abnormal pharyngeal arch artery morphology J:26778
absent right subclavian artery J:26778
aorta tubular hypoplasia J:26778
dilated heart right ventricle J:26778
double outlet right ventricle J:26778
interrupted aorta J:26778
overriding aortic valve J:26778
ventricular septal defect J:26778
Edn1tm1Ywa/Edn1tm1Ywa
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:196635
Edn1tm1Ywa/Edn1tm1Ywa
Tg(Aqp2-cre)1Dek/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal kidney physiology J:104785
abnormal urine homeostasis J:104785
decreased circulating antidiuretic hormone level J:104785
decreased circulating sodium level J:104785
increased urine osmolality J:104785
oliguria J:104785
normal renal/urinary system phenotype J:104785
Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		increased systemic arterial systolic blood pressure J:116002
Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA 		decreased urine sodium level J:91968
hypertension J:91968
salt-sensitive hypertension J:91968
Edn1tm1Ywa/Edn1tm1Ywa
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * FVB/N 		decreased response of heart to induced stress J:90390, J:96386
Edn1tm1Ywa/Edn1tm1Ywa
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		normal cardiovascular system phenotype J:196635
decreased mean systemic arterial blood pressure J:196635
decreased systemic arterial diastolic blood pressure J:196635
decreased systemic arterial systolic blood pressure J:196635
normal embryo phenotype J:196635
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory