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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Egfr
epidermal growth factor receptor
MGI:95294
196 phenotypes from 15 alleles in 30 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egfrm2Btlr/Egfrm2Btlr
C57BL/6J-Egfrm2Btlr 		disheveled coat J:231805
rough coat J:231805
thick skin J:231805
EgfrMhdadsk5/Egfr+
C3HeB/FeJ-EgfrMhdadsk5/Ieg 		abnormal nail morphology J:81301
abnormal skin pigmentation J:81301
increased foot pad pigmentation J:81301
thick epidermis J:81301
waved hair J:81301
EgfrMhdadsk5/Egfr+
involves: 129S1/SvImJ * C3HeB/FeJ 		increased susceptibility to Coronaviridae infection J:243599
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:243599
EgfrMhdadsk5/EgfrMhdadsk5
involves: C3HeB/FeJ * C57BL/6J 		abnormal skin pigmentation J:81301
increased foot pad pigmentation J:81301
long toenails J:81301
thick epidermis J:81301
waved hair J:81301
Egfrtm1.1Dwt/Egfrtm1.1Dwt
involves: 129S6/SvEvTac 		abnormal dorsal root ganglion morphology J:145069
abnormal hair follicle morphology J:145069
abnormal sensory neuron innervation pattern J:145069
Egfrtm1.1Tyj/Egfrtm1.1Tyj
involves: 129 * C57BL/6 		embryonic lethality, complete penetrance J:101977
Egfrtm1a(EUCOMM)Wtsi/Egfr+
C57BL/6N-Egfrtm1a(EUCOMM)Wtsi/Wtsi 		decreased leukocyte cell number J:175295
Egfrtm1Dwt/Egfrtm1Dwt
Sox9tm3(cre)Crm/Sox9+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal epidermal layer morphology J:229771
abnormal skin morphology J:229771
dermatitis J:229771
impaired skin barrier function J:229771
increased IgE level J:229771
increased T-helper 1 cell number J:229771
increased T-helper 2 cell number J:229771
increased T-helper 17 cell number J:229771
Egfrtm1Dwt/Egfrtm1Dwt
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal placenta labyrinth morphology J:145161
abnormal spongiotrophoblast layer morphology J:145161
decreased embryo size J:145161
placental labyrinth hypoplasia J:145161
Egfrtm1Dwt/Egfrtm1Dwt
Tg(KRT14-cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA 		waved hair J:145161
Egfrtm1Dwt/Egfrtm1Dwt
Tg(KRT14-cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal hair follicle morphology J:145069
normal nervous system phenotype J:145069
Egfrtm1Dwt/Egfrtm1Mag
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J 		normal growth/size/body region phenotype J:145161
normal integument phenotype J:145161
normal reproductive system phenotype J:145161
Egfrtm1Mag/Egfrtm1Mag
involves: 129/Sv * 129S2/SvPas 		abnormal placenta labyrinth morphology J:26833
decreased spongiotrophoblast size J:26833
decreased trophoblast giant cell number J:26833
embryonic lethality at implantation, complete penetrance J:26833
embryonic lethality during organogenesis, complete penetrance J:26833
perinatal lethality, complete penetrance J:26833
small placenta J:26833
Egfrtm1Mag/Egfrtm1Mag
involves: 129S2/SvPas * CD-1 		abnormal cerebellum external granule cell layer morphology J:26833
abnormal cerebral cortex morphology J:26833
abnormal coat appearance J:26833
abnormal colon morphology J:26833
abnormal esophageal epithelium morphology J:26833
abnormal filiform papillae morphology J:26833
abnormal fungiform papillae morphology J:26833
abnormal hair follicle development J:26833
abnormal hair follicle inner root sheath morphology J:26833
abnormal hair follicle orientation J:26833
abnormal hair shaft morphology J:26833
abnormal hepatocyte morphology J:26833
abnormal liver morphology J:26833
abnormal lung development J:26833
abnormal olfactory bulb morphology J:26833
abnormal tongue morphology J:26833
absent eyelids J:26833
cachexia J:26833
curly vibrissae J:26833
decreased brain size J:26833
decreased Purkinje cell number J:26833
delayed hair appearance J:26833
dilated kidney collecting duct J:26833
distorted hair follicle pattern J:26833
eyelids open at birth J:26833
increased blood urea nitrogen level J:26833
increased circulating creatinine level J:26833
perinatal lethality, complete penetrance J:26833
postnatal growth retardation J:26833
small cerebellum J:26833
thin cerebral cortex J:26833
wavy vibrissae J:26833
Egfrtm1Mag/Egfrtm1Mag
involves: 129S2/SvPas * CF-1 		abnormal inner cell mass morphology J:26833
embryonic lethality between implantation and somite formation, incomplete penetrance J:26833
Egfrtm1Mag/Egfrwa2
involves: 129S2/SvPas * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * CD-1 		thick aortic valve J:60750
Egfrtm1Msi/Egfrtm1Msi
Tg(Alb1-cre)7Gsc/?
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		delayed liver regeneration J:125912
increased circulating tumor necrosis factor level J:125912
increased susceptibility to induced morbidity/mortality J:125912
slow postnatal weight gain J:125912
Egfrtm1Msi/Egfrtm1Msi
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		delayed liver regeneration J:125912
increased circulating tumor necrosis factor level J:125912
increased susceptibility to induced morbidity/mortality J:125912
Egfrtm1Rdk/Egfrtm1Rdk
involves: 129X1/SvJ * Black Swiss 		abnormal branching involved in lung morphogenesis J:41158
abnormal bronchus morphology J:27464, J:41158
abnormal epidermis stratum basale morphology J:27464
abnormal epidermis stratum granulosum morphology J:27464
abnormal exocrine pancreas morphology J:62160
abnormal hair follicle development J:27464
abnormal hair growth J:27464
abnormal intestinal absorption J:27464
abnormal intestine morphology J:27464
abnormal lung interstitium morphology J:41158
abnormal outer ear morphology J:27464
abnormal pancreas morphology J:62160
abnormal pancreatic beta cell morphology J:62160
abnormal pulmonary acinus morphology J:41158
abnormal pulmonary alveolus morphology J:27464, J:41158
abnormal pulmonary interalveolar septum morphology J:41158
abnormal skin appearance J:27464
abnormal submandibular gland branching morphogenesis J:69420
abnormal terminal bronchiole morphology J:41158
abnormal tongue epithelium morphology J:27464
abnormal type II pneumocyte morphology J:41158
atelectasis J:41158
cleft palate J:27464, J:54535
curly vibrissae J:27464
cyanosis J:41158
decreased alveolar lamellar body number J:41158
decreased body size J:27464
decreased embryo size J:27464
decreased fetal size J:27464
dilated respiratory conducting tube J:41158
dilated terminal bronchiole tube J:41158
disorganized pancreatic islets J:62160
dry skin J:27464
embryonic lethality during organogenesis, incomplete penetrance J:27464
eyelids open at birth J:27464
flaky skin J:27464
fused cornea and lens J:27464
hematoma J:27464
impaired lung alveolus development J:41158
increased heart rate J:27464
petechiae J:27464
pointed snout J:54535
postnatal lethality, complete penetrance J:27464
respiratory distress J:41158
respiratory failure J:41158
short mandible J:54535
small Meckel's cartilage J:54535
small pancreas J:62160
small placenta J:27464
thick pulmonary interalveolar septum J:27464, J:41158
thin epidermis J:27464
weight loss J:27464
Egfrtm1Wag/Egfrtm1Wag
involves: 129 		decreased embryo size J:26834
decreased embryo weight J:26834
embryonic lethality during organogenesis, complete penetrance J:26834
small placenta J:26834
Egfrtm1Wag/Egfrtm1Wag
involves: 129 * C57BL/6 		abnormal bronchiole epithelium morphology J:26834
abnormal epidermal layer morphology J:26834
abnormal epidermis stratum corneum morphology J:26834
abnormal hair follicle morphology J:26834
abnormal maternal decidual layer morphology J:26834
abnormal placenta morphology J:26834
abnormal pulmonary alveolus epithelium morphology J:26834
abnormal vibrissa morphology J:26834
absent vibrissae J:26834
decreased cornea thickness J:26834
decreased embryo size J:26834
decreased embryo weight J:26834
decreased spongiotrophoblast size J:26834
embryonic lethality during organogenesis, incomplete penetrance J:26834
eyelids open at birth J:26834
lethality throughout fetal growth and development, incomplete penetrance J:26834
postnatal lethality, complete penetrance J:26834
small placenta J:26834
thick pulmonary interalveolar septum J:26834
thin epidermis J:26834
Egfrtm1Wag/Egfrtm1Wag
involves: 129 * C57BL/6 * MF1 		cachexia J:26834
decreased body weight J:26834
dehydration J:26834
postnatal lethality, incomplete penetrance J:26834
EgfrVel/Egfr+
involves: C57BL/6J 		abnormal eyelid development J:88776
abnormal eyelid morphology J:88776
abnormal hair follicle orientation J:88776
cornea opacity J:88776
curly vibrissae J:88776
decreased fibroblast cell migration J:88776
eyelids open at birth J:88776
failure of eyelid fusion J:88776
microphthalmia J:88776
plush coat J:88776
waved hair J:88776
weight loss J:166602
EgfrVel/EgfrVel
involves: C57BL/6J 		abnormal trophoblast layer morphology J:88776
embryonic lethality during organogenesis, complete penetrance J:88776
placental labyrinth hypoplasia J:88776
Egfrwa2-4J/Egfrwa2-4J
involves: C57BL/6J * DBA/2J 		waved hair J:78380
Egfrwa2/Egfrwa2
B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 		abnormal hair texture J:16986
abnormal lactation J:23326
abnormal mammary gland morphology J:23326
abnormal vibrissa morphology J:16986
enlarged aortic valve J:60750
thick aortic valve J:60750
Egfrwa2/Egfrwa2
involves: C57BL/6 		abnormal aorta morphology J:241813
abnormal aortic valve morphology J:241813
abnormal heart left ventricle morphology J:241813
abnormal heart valve physiology J:241813
abnormal myocardial fiber morphology J:241813
aortic valve regurgitation J:241813
aortic valve stenosis J:241813
calcified aortic valve J:241813
cardiac fibrosis J:241813
decreased heart left ventricle muscle contractility J:241813
decreased heart right ventricle muscle contractility J:241813
decreased heart ventricle muscle contractility J:241813
heart left ventricle hypertrophy J:241813
increased cardiac stroke volume J:241813
increased heart left ventricle size J:241813
increased pulse pressure J:241813
Egfrwa2/Egfrwa2
STOCK ac 		abnormal eye morphology J:15329
abnormal hair cortex keratinization J:5260
abnormal hair medulla J:5260
cataract J:15329
curly vibrissae J:13052
decreased body size J:13052
increased curvature of guard hairs J:13052
increased curvature of hairs J:5260
short hair J:13052
short vibrissae J:13052
waved hair J:5260, J:13052
Egfrwa2/Egfrwa2
STOCK Egfrwa2 		abnormal aortic valve morphology J:60750
aortic valve regurgitation J:60750
enlarged semilunar valve J:60750
increased left ventricle systolic pressure J:60750
prolonged PR interval J:60750
prolonged RR interval J:60750
Egfrwa2/EgfrWa5
involves: BALB/cAnN * C3H/HeN * C57BL/6J 		abnormal eye morphology J:92308
abnormal fertility/fecundity J:92308
abnormal vagina orifice morphology J:92308
alopecia J:92308
asymmetric snout J:92308
decreased body weight J:92308
long snout J:92308
loss of vibrissae J:92308
mandible hypoplasia J:92308
narrow snout J:92308
perinatal lethality, incomplete penetrance J:92308
postnatal growth retardation J:92308
postnatal lethality, incomplete penetrance J:92308
EgfrWa5/Egfr+
involves: BALB/cAnN * C3H/HeN 		abnormal eye morphology J:75964
abnormal hair texture J:75964
abnormal vibrissa morphology J:75964
cornea scarring J:75964
curly vibrissae J:75964
eyelids open at birth J:75964
waved hair J:75964
EgfrWa5/Egfr+
involves: BALB/cAnN * C3H/HeN * C57BL/6J 		abnormal placenta labyrinth morphology J:92308
abnormal placenta morphology J:92308
decreased spongiotrophoblast size J:92308
EgfrWa5/EgfrWa5
involves: BALB/cAnN * C3H/HeN 		preweaning lethality, complete penetrance J:75964
EgfrWa5/EgfrWa5
involves: BALB/cAnN * C3H/HeN * C57BL/6J 		abnormal placenta labyrinth morphology J:92308
abnormal placenta morphology J:92308
decreased spongiotrophoblast size J:92308
embryonic lethality during organogenesis, incomplete penetrance J:92308
lethality throughout fetal growth and development, incomplete penetrance J:92308
Tg(Gh1-rtTA)4-3Jek/0
Tg(tetO-Egfr*)2-9Jek/0
involves: C57BL/6 * SJL 		abnormal gonadotroph morphology J:68692
abnormal reproductive system physiology J:68692
decreased body size J:68692
decreased lactotroph cell number J:68692
decreased somatotroph cell number J:68692
delayed eyelid opening J:68692
postnatal growth retardation J:68692
postnatal lethality J:68692
slow postnatal weight gain J:68692
small adenohypophysis J:68692
Tg(Prl-tTA)6-5Jek/0
Tg(tetO-Egfr*)2-9Jek/0
involves: C57BL/6 * SJL 		normal endocrine/exocrine gland phenotype J:68692
normal growth/size/body region phenotype J:68692
normal homeostasis/metabolism phenotype J:68692
normal reproductive system phenotype J:68692
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory