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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Egfr
epidermal growth factor receptor
MGI:95294
87 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
EgfrWa5/Egfr+
involves: BALB/cAnN * C3H/HeN * C57BL/6J 		decreased tumor incidence J:92308
Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfr+
Tg(KRT5-cre)5132Jlj/0
involves: 129 * C57BL/6 * CD-1 		abnormal coat/ hair morphology J:141162
abnormal eye morphology J:141162
decreased survivor rate J:141162
premature death J:141162
thick epidermis J:141162
Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfrtm1Mag
Tg(KRT5-cre)5132Jlj/0
involves: 129 * C57BL/6 * CD-1 		postnatal lethality, complete penetrance J:141162
Chuktm1Yhu/Chuktm1Yhu
Egfrwa2/Egfrwa2
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal epidermal layer morphology J:141162
normal integument phenotype J:141162
premature death J:141162
Egfrtm1Wag/Egfrtm2(EGFR)Wag
involves: 129 		prenatal lethality, complete penetrance J:84870
Egfrtm1Wag/Egfrtm2(EGFR)Wag
involves: 129/Sv * C57BL/6 		prenatal lethality, complete penetrance J:84870
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
involves: 129 		prenatal lethality, complete penetrance J:84870
Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
involves: 129/Sv * C57BL/6 		abnormal hair cycle J:84870
abnormal hair follicle orientation J:84870
abnormal semilunar valve morphology J:84870
alopecia J:84870
cardiac hypertrophy J:84870
curly vibrissae J:84870
decreased body size J:84870
decreased body weight J:84870
decreased hair follicle number J:84870
delayed hair appearance J:84870
enhanced osteoblast differentiation J:84870
heart left ventricle hypertrophy J:84870
normal nervous system phenotype J:84870
postnatal growth retardation J:84870
premature chondrocyte differentiation J:84870
premature death J:84870
prenatal lethality, incomplete penetrance J:84870
short hair J:84870
sparse hair J:84870
Egfrwa2/Egfr+
Nf1tm1Fcr/Nf1+
Trp53tm1Brd/Trp53+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ 		decreased tumor incidence J:95933
Egfrwa2/Egfr+
Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Rps6ka3tm1.1Kry/Y
Tg(KRT5-SOS1)892A6Wag/0
involves: 129X1/SvJ * C57BL/6 * CBA 		decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Errfi1tm1Kln/Errfi1tm1Kln
involves: 129P2/OlaHsd * C3H/HeSnJ * C57BL/6 		abnormal skin morphology J:109556
Egfrwa2/Egfr+
Fostm3.1Wag/Fostm3.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
increased skin tumor incidence J:175064
Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		increased skin papilloma incidence J:175064
increased tumor growth/size J:175064
Egfrwa2/Egfr+
Tg(KRT5-SOS1)892A6Wag/0
involves: C57BL/6 * CBA 		increased skin papilloma incidence J:175064
increased skin tumor incidence J:175064
Egfrwa2/Egfrwa2
Eregtm1Dwt/Eregtm1Dwt
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:93327
Egfrwa2/Egfrwa2
Errfi1tm1Kln/Errfi1tm1Kln
involves: 129P2/OlaHsd * C3H/HeSnJ * C57BL/6 		normal integument phenotype J:109556
Egfrwa2/Egfrwa2
Ptpn11tm1Paw/Ptpn11+
involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6 		abnormal breathing pattern J:75413
abnormal hair follicle development J:75413
abnormal hair follicle morphology J:75413
abnormal hair follicle orientation J:75413
abnormal hair growth J:75413
abnormal intestine morphology J:75413
abnormal lung development J:75413
abnormal muscle morphology J:75413
abnormal skin condition J:75413
atelectasis J:75413
cachexia J:75413
decreased hair follicle number J:75413
decreased subcutaneous adipose tissue amount J:75413
dry skin J:75413
epidermal atrophy J:75413
eyelids open at birth J:75413
flaky skin J:75413
intestinal hypoperistalsis J:75413
postnatal growth retardation J:75413
postnatal lethality, incomplete penetrance J:75413
thick pulmonary interalveolar septum J:75413
thin epidermis J:75413
thin skin J:75413
waved hair J:75413
Egfrwa2/Egfrwa2
Ptpn11tm1Rbn/Ptpn11+
involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt 		abnormal impulse conducting system conduction J:60750
aortic valve regurgitation J:60750
aortic valve stenosis J:60750
congestive heart failure J:60750
enlarged semilunar valve J:60750
eyelids open at birth J:60750
increased left ventricle diastolic pressure J:60750
increased left ventricle systolic pressure J:60750
increased systemic arterial blood pressure J:60750
myocardium hypertrophy J:60750
perinatal lethality, incomplete penetrance J:60750
prolonged PR interval J:60750
prolonged QRS complex duration J:60750
prolonged QT interval J:60750
prolonged RR interval J:60750
prolonged ST segment J:60750
thick aortic valve J:60750
thick pulmonary valve J:60750
Egfrwa2/Egfrwa2
Sos1tm1Dlb/Sos1+
involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt 		abnormal ciliary body morphology J:38321
abnormal cornea morphology J:38321
abnormal eye anterior chamber morphology J:38321
abnormal lens fiber morphology J:38321
abnormal retina morphology J:38321
anterior iris synechia J:38321
cornea opacity J:38321
cornea vascularization J:38321
eyelids open at birth J:38321
fused cornea and lens J:38321
increased cornea thickness J:38321
lens vacuoles J:38321
microphthalmia J:38321
preweaning lethality, incomplete penetrance J:38321
small lens J:38321
EgfrWa5/Egfr+
Tgfatm1Unc/Tgfatm1Unc
involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J 		postnatal growth retardation J:92308
small mandible J:92308
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory