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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Egr1
early growth response 1
MGI:95295
93 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egr1tm1b(NCOM)Mfgc/Egr1+
C57BL/6N-Egr1tm1b(NCOM)Mfgc/Tcp 		decreased body length J:211773
increased lymphocyte cell number J:211773
short tibia J:211773
Egr1tm1b(NCOM)Mfgc/Egr1tm1b(NCOM)Mfgc
C57BL/6N-Egr1tm1b(NCOM)Mfgc/Tcp 		abnormal embryo size J:211773
abnormal forebrain development J:211773
abnormal hindbrain development J:211773
abnormal midbrain development J:211773
abnormal neural tube closure J:211773
abnormal optic disk morphology J:211773
absent seminal vesicle J:211773
embryonic growth retardation J:211773
female infertility J:211773
male infertility J:211773
preweaning lethality, incomplete penetrance J:211773
small uterus J:211773
Egr1tm1Jmi/Egr1tm1Jmi
B6.129-Egr1tm1Jmi 		abnormal circulating alanine transaminase level J:128421
abnormal circulating tumor necrosis factor level J:128421
abnormal liver physiology J:128421
abnormal trabecular bone morphology J:62113
normal cardiovascular system phenotype J:96665
decreased bone mineral density J:62113
increased osteoclast cell number J:51107
liver inflammation J:128421
normal liver/biliary system phenotype J:128421
Egr1tm1Jmi/Egr1tm1Jmi
involves: 129 		abnormal circulating progesterone level J:35132
abnormal ovary morphology J:35132
abnormal ovulation J:35132
abnormal reproductive system physiology J:35132
abnormal vascular wound healing J:61294
absent corpus luteum J:35132
absent estrous cycle J:35132
cardiac fibrosis J:61294
decreased luteinizing hormone level J:35132
decreased uterus weight J:35132
female infertility J:35132
Leydig cell atrophy J:35132
Egr1tm1Jmi/Egr1tm1Jmi
involves: 129 * C57BL/6 		abnormal circulating alanine transaminase level J:105638
abnormal cornea morphology J:123287
abnormal erythropoiesis J:123870
abnormal eye morphology J:123287
abnormal eye size J:123287
abnormal hematopoietic stem cell morphology J:149801
abnormal homeostasis J:105638
abnormal leukocyte cell number J:123870
abnormal leukocyte morphology J:123870
abnormal liver physiology J:105638
abnormal liver size J:105638
abnormal microglial cell physiology J:135238
abnormal mitosis J:93996
abnormal neutrophil morphology J:123870
abnormal physiological response to xenobiotic J:105638
abnormal response to injury J:135238
abnormal tumor necrosis factor level J:105638
abnormal vision J:123287
anemia J:123870
decreased cerebral infarct size J:135238
decreased inflammatory response J:152898
decreased mitotic index J:93996
decreased tumor latency J:99386
delayed wound healing J:152898
normal immune system phenotype J:105638
impaired liver regeneration J:93996
increased bone marrow cell number J:123870
increased eye anterior chamber depth J:123287
increased incidence of tumors by chemical induction J:123870
increased liver triglyceride level J:105638
increased lymphocyte cell number J:123870
increased skin papilloma incidence J:99386
increased spleen weight J:123870
increased T cell derived lymphoma incidence J:123870
normal liver/biliary system phenotype J:105638
normal neoplasm J:123870
postnatal growth retardation J:123870
pulmonary fibrosis J:152898
pulmonary interstitial fibrosis J:152898
normal respiratory system phenotype J:152898
thick dermal layer J:152898
thrombocytopenia J:123870
Egr1tm1Lch/Egr1tm1Lch
involves: 129/Sv * C57BL/6 		abnormal long-term object recognition memory J:86638
Egr1tm1Pch/Egr1tm1Pch
involves: 129S2/SvPas * C57BL/6J 		abnormal endometrium morphology J:45064
abnormal pituitary secretion J:45064
abnormal sexual interaction J:45064
absent corpus luteum J:45064
absent mature ovarian follicles J:45064
adenohypophysis hypoplasia J:45064
anovulation J:45064
decreased aggression J:45064
decreased body size J:45064
decreased body weight J:45064
decreased circulating testosterone level J:45064
decreased growth hormone level J:45064
decreased Leydig cell number J:45064
decreased somatotroph cell number J:45064
decreased testis weight J:45064
female infertility J:45064
male infertility J:45064
oligozoospermia J:45064
postnatal growth retardation J:45064
small prostate gland J:45064
small seminal vesicle J:45064
small seminiferous tubules J:45064
small uterus J:45064
Egr1tm1The/Egr1tm1The
involves: 129S7/SvEvBrd * C57BL/6 		female infertility J:73383
normal nervous system phenotype J:73383
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory