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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Egr2
early growth response 2
MGI:95296
74 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egr2tm1Grid/Egr2tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal cochlear ganglion morphology J:15577
abnormal cranial ganglia morphology J:15577
abnormal cranial nerve morphology J:15577
abnormal trigeminal ganglion morphology J:15577
absent rhombomere 3 J:15577
absent rhombomere 5 J:15577
decreased body size J:15577
fusion of glossopharyngeal and vagus nerve J:15577
neonatal lethality, incomplete penetrance J:15577
postnatal lethality, complete penetrance J:15577
Egr2tm1Jmi/Egr2tm1Jmi
Not Specified 		abnormal hindbrain development J:96641
abnormal myelination J:96641, J:99824
abnormal Schwann cell morphology J:96641, J:99824
abnormal sciatic nerve morphology J:96641
decreased body size J:96641
impaired coordination J:96641
increased Schwann cell proliferation J:96641
postnatal lethality, complete penetrance J:96641
tremors J:96641
Egr2tm1Pch/Egr2tm1Pch
involves: 129S2/SvPas 		abnormal aortic valve morphology J:230306
enlarged aortic valve J:230306
thick aortic valve cusps J:230306
thick pulmonary valve cusps J:230306
Egr2tm1Pch/Egr2tm1Pch
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal abducens nerve morphology J:16077
abnormal bone mineralization J:30822
abnormal bone structure J:30822
abnormal cranial ganglia morphology J:16077
abnormal cranial nerve morphology J:16077
abnormal facial nerve morphology J:16077, J:39350
abnormal glossopharyngeal nerve morphology J:16077, J:39350
abnormal long bone epiphyseal plate morphology J:30822
abnormal long bone morphology J:30822
abnormal mandible morphology J:30822
abnormal motor capabilities/coordination/movement J:16077
abnormal neural tube morphology J:16077
abnormal rhombomere morphology J:16077
abnormal Schwann cell morphology J:21073
abnormal sciatic nerve morphology J:21073
abnormal skeleton development J:30822
abnormal somatic nervous system morphology J:16077
abnormal trigeminal nerve morphology J:16077, J:39350
abnormal vagus nerve morphology J:16077
absent rhombomere 3 J:39350
absent rhombomere 5 J:39350
decreased body weight J:16077
decreased diameter of femur J:30822
decreased diameter of long bones J:30822
decreased diameter of radius J:30822
decreased diameter of tibia J:30822
decreased length of long bones J:30822
decreased locomotor activity J:16077
decreased rhombomere 3 size J:39350
decreased rhombomere 5 size J:39350
decreased rhombomere 6 size J:39350
decreased width of hypertrophic chondrocyte zone J:30822
delayed eyelid opening J:16077
postnatal growth retardation J:16077
postnatal lethality, incomplete penetrance J:16077
short femur J:30822
short radius J:30822
short tibia J:30822
tremors J:16077, J:21073
weight loss J:16077
Egr2tm1Pch/Egr2tm3Pch
involves: 129S2/SvPas * C57BL/6 * DBA/2 		decreased rhombomere 3 size J:75128
Egr2tm2Jmi/Egr2+
B6.Cg-Egr2tm2Jmi 		fusion of glossopharyngeal and vagus nerve J:145949
Egr2tm2Jmi/Egr2tm2Jmi
B6.Cg-Egr2tm2Jmi 		abnormal gait J:145949
abnormal myelination J:145949
abnormal neuromuscular synapse morphology J:145949
abnormal Schwann cell morphology J:145949
abnormal sciatic nerve morphology J:145949
decreased nerve conduction velocity J:145949
fusion of glossopharyngeal and vagus nerve J:145949
hindlimb paralysis J:145949
normal integument phenotype J:145949
postnatal lethality, complete penetrance J:145949
respiratory distress J:145949
tremors J:145949
weakness J:145949
weight loss J:145949
Egr2tm3Pch/Egr2tm3Pch
Tg(Tek-cre)1Ywa/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal aortic valve cusp morphology J:230306
abnormal cardiovascular system physiology J:230306
abnormal heart left ventricle morphology J:230306
aorta stenosis J:230306
aortic valve regurgitation J:230306
heart left ventricle hypertrophy J:230306
thick aortic valve cusps J:230306
thick pulmonary valve cusps J:230306
Egr2tm4Pch/Egr2tm4Pch
involves: BALB/c * C57BL/6 		abnormal cochlear ganglion morphology J:137156
abnormal geniculate ganglion morphology J:137156
abnormal glossopharyngeal ganglion morphology J:137156
abnormal myelination J:137156
abnormal trigeminal ganglion morphology J:137156
abnormal vagus ganglion morphology J:137156
decreased body size J:137156
impaired limb coordination J:137156
increased pulmonary respiratory rate J:137156
increased Schwann cell proliferation J:137156
lethality at weaning, complete penetrance J:137156
paralysis J:137156
tremors J:137156
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory