Egr2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Egr2
early growth response 2
MGI:95296

51 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1d^tm1Hgn/Cacna1d^tm1Hgn Egr2^tm2(cre)Pch/Egr2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal auditory brainstem response waveform shape	J:185977
	abnormal distortion product otoacoustic emission	J:185977
	abnormal pons morphology	J:185977
	decreased neuron number	J:185977
	increased or absent distortion product otoacoustic emission threshold	J:185977
Crygn^{tm1a(EUCOMM)Wtsi}/Crygn^{tm1a(EUCOMM)Wtsi} Egr2^tm2(cre)Pch/Egr2⁺ involves: 129S2/SvPas * C57BL/6N	abnormal auditory brainstem response	J:236916
	abnormal pons morphology	J:236916
	decreased neuron number	J:236916
	normal hearing/vestibular/ear phenotype	J:236916
	normal nervous system phenotype	J:236916
Egr2^tm1.1Jchn/Egr2⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	absent rhombomere 3	J:82071
	absent rhombomere 5	J:82071
Egr2^tm1.1Jchn/Egr2^tm1Pch involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal motor neuron morphology	J:82071
	abnormal neuronal migration	J:82071
	abnormal spinal cord morphology	J:82071
Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm1Cbm/Erbb2^tm2Cbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal dorsal spinal root morphology	J:75421
	abnormal gait	J:75421
	abnormal locomotor activation	J:75421
	abnormal myelin sheath morphology	J:75421
	abnormal myelination	J:75421
	abnormal sciatic nerve morphology	J:75421
	abnormal ventral spinal root morphology	J:75421
	cachexia	J:75421
	decreased Schwann cell number	J:75421
	kinked tail	J:75421
	premature death	J:75421
Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm2Cbm/Erbb2^tm2Cbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	normal behavior/neurological phenotype	J:199150
	demyelination	J:199150
Egr2^tm2(cre)Pch/Egr2⁺ Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	abnormal myelination	J:153219, J:207470
	decreased motor neuron number	J:153219
	decreased nerve conduction velocity	J:153219
Egr2^tm2(cre)Pch/Egr2⁺ Phox2b^tm4Jbr/Phox2b⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal autonomic nervous system physiology	J:176573
	abnormal respiratory function	J:176573
	abnormal retrotrapezoid nucleus morphology	J:176573
	alkalemia	J:176573
	decreased pulmonary ventilation	J:176573
	normal mortality/aging	J:176573
Egr2^tm2(cre)Pch/Egr2⁺ Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/? involves: 129S2/SvPas C57BL/6	abnormal myelination	J:207470
Egr2^tm2(cre)Pch/Egr2⁺ Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/? Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm involves: 129P2/OlaHsd 129S2/SvPas * C57BL/6	abnormal myelination	J:207470
Egr2^tm2(cre)Pch/Egr2⁺ Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/? involves: 129S2/SvPas C57BL/6	abnormal myelin sheath morphology	J:207470
	abnormal nerve conduction	J:207470
	abnormal sciatic nerve morphology	J:207470
	hypermyelination	J:207470
	increased myelin sheath thickness	J:207470
	increased nerve conduction velocity	J:207470
	tomacula	J:207470
Egr2^tm2(cre)Pch/Egr2⁺ Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/? Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm involves: 129P2/OlaHsd 129S2/SvPas * C57BL/6	hypermyelination	J:207470
Egr2^tm2(cre)Pch/Egr2⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache involves: 129S2/SvPas	abnormal auditory brainstem response	J:158918
	abnormal brain commissure morphology	J:158918
	abnormal horizontal vestibuloocular reflex	J:158918
	abnormal innervation	J:158918
	abnormal optokinetic reflex	J:158918
	abnormal reflex	J:158918
Egr2^tm2(cre)Pch/Egr2⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache Tg(Mnx1-EGFP)#Tmj/0 involves: 129S2/SvPas * C57BL/6 * DBA	abnormal pons morphology	J:158918
Egr2^tm2(cre)Pch/? Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/? Tg(Fev-flpe)1Dym/? involves: 129S2/SvPas	no abnormal phenotype detected	J:136096
Egr2^tm2(cre)Pch/? Mnat1^tm2Tpm/Mnat1^tm2.1Tpm involves: 129S2/SvPas	abnormal gait	J:120170
	abnormal Schwann cell precursor morphology	J:120170
	abnormal spermatogenesis	J:120170
	decreased lean body mass	J:120170
	demyelination	J:120170
Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Egr2^tm2(cre)Pch/Egr2⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal neuron differentiation	J:155885
	abnormal neuron physiology	J:155885
	postnatal lethality, complete penetrance	J:155885

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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