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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Eif2s1
eukaryotic translation initiation factor 2, subunit 1 alpha
MGI:95299
14 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Eif2s1em1(IMPC)Mbp/Eif2s1+
C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd 		abnormal skin morphology J:211773
decreased prepulse inhibition J:211773
decreased startle reflex J:211773
increased bone mineral content J:211773
Eif2s1em1(IMPC)Mbp/Eif2s1em1(IMPC)Mbp
C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to organogenesis, complete penetrance J:279207
failure of blastocyst to hatch from the zona pellucida J:279207
failure of embryo implantation J:279207
preweaning lethality, complete penetrance J:211773
Eif2s1tm1Rjk/Eif2s1tm1Rjk
involves: 129S1/Sv * 129X1/SvJ 		abnormal suckling behavior J:70004
decreased circulating insulin level J:70004
decreased insulin secretion J:70004
hypoglycemia J:70004
neonatal lethality, complete penetrance J:70004
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory