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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Eif4b
eukaryotic translation initiation factor 4B
MGI:95304
30 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Eif4bem1(IMPC)J/Eif4b+
C57BL/6NJ-Eif4bem1(IMPC)J/Mmjax 		abnormal auditory brainstem response J:211773
abnormal locomotor behavior J:211773
increased grip strength J:211773
prolonged RR interval J:211773
Eif4bem1(IMPC)J/Eif4bem1(IMPC)J
C57BL/6NJ-Eif4bem1(IMPC)J/Mmjax 		edema J:211773
embryonic growth retardation J:211773
hemorrhage J:211773
preweaning lethality, complete penetrance J:211773
Eif4btm1.1Smoc/Eif4b+
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 		increased susceptibility to Riboviria infection J:311140
Eif4btm1.1Smoc/Eif4btm1.1Smoc
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
involves: 129 * C57BL/6 		decreased food intake J:311140
decreased leukocyte cell number J:311140
decreased locomotor activity J:311140
decreased lymphocyte cell number J:311140
decreased NK cell number J:311140
increased macrophage cell number J:311140
increased neutrophil cell number J:311140
increased susceptibility to induced colitis J:311140
increased susceptibility to Orthomyxoviridae infection J:311140
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:311140
lung inflammation J:311140
matted coat J:311140
premature death J:311140
small spleen J:311140
small thymus J:311140
weight loss J:311140
Eif4btm1.1Smoc/Eif4btm1.1Smoc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 		increased susceptibility to Orthomyxoviridae infection J:311140
Eif4btm1.2Smoc/Eif4btm1.2Smoc
Not Specified 		abnormal embryo morphology J:311140
decreased fetal size J:311140
lethality throughout fetal growth and development, complete penetrance J:311140
pallor J:311140
small liver J:311140
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory