Eif4e Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif4e
eukaryotic translation initiation factor 4E
MGI:95305

26 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Eif4e^tm1.1Lfur/Eif4e^tm1.1Lfur involves: 129X1/SvJ	abnormal cell physiology	J:163589
Eif4e^{tm1b(EUCOMM)Hmgu}/Eif4e^{tm1b(EUCOMM)Hmgu} C57BL/6N-Eif4e^{tm1b(EUCOMM)Hmgu}/Tcp	preweaning lethality, complete penetrance	J:211773
Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e⁺ involves: FVB/NJ	decreased body weight	J:308879
Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e⁺ involves: FVB/NJ	normal embryo phenotype	J:308879
Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e^{Tn(pb-Act-RFP)1Xwu} involves: FVB/NJ	abnormal embryo implantation	J:308879
	abnormal embryonic epiblast morphology	J:308879
	abnormal translation	J:308879
	embryonic lethality before implantation, incomplete penetrance	J:308879
	embryonic lethality between implantation and somite formation, complete penetrance	J:308879
Tg(ACTB-Eif4e)#Ppp/? B6.Cg-Tg(ACTB-Eif4e)#Ppp	abnormal forebrain morphology	J:194400
	abnormal inhibitory learning	J:194400
	abnormal long-term depression	J:194400
	abnormal miniature excitatory postsynaptic currents	J:194400
	abnormal social investigation	J:194400
	hyperactivity	J:194400
	increased grooming behavior	J:194400
	increased miniature inhibitory postsynaptic current amplitude	J:194400
	increased stereotypic behavior	J:194400
Tg(ACTB-Eif4e)#Ppp/0 involves: C57BL/6	abnormal brain morphology	J:227667
	abnormal social investigation	J:227667
	increased locomotor activity	J:227667
	increased stereotypic behavior	J:227667
Tg(ACTB-Eif4e)#Ppp/? Not Specified	early cellular replicative senescence	J:89878
	increased B cell derived lymphoma incidence	J:89878
	increased liver adenoma incidence	J:89878
	increased lung adenocarcinoma incidence	J:89878
	increased sarcoma incidence	J:89878
	increased tumor incidence	J:89878

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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