Emx2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Emx2
empty spiracles homeobox 2
MGI:95388

64 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Emx2^Pdo/Emx2⁺ involves: BALB/c	abnormal cochlea morphology	J:250208
	abnormal cochlear inner hair cell morphology	J:250208
	abnormal incus morphology	J:250208
	abnormal malleus morphology	J:250208
	abnormal middle ear ossicle morphology	J:250208
	abnormal stapes morphology	J:250208
	impaired hearing	J:250208
	increased cochlear nerve compound action potential	J:250208
	increased cochlear outer hair cell number	J:250208
Emx2^Pdo/Emx2⁺ involves: BALB/c * C3H/HeN	abnormal incudomalleolar joint morphology	J:89093
	abnormal incudostapedial joint morphology	J:89093
	abnormal incus long process morphology	J:89093
	abnormal malleus morphology	J:89093
	abnormal middle ear ossicle morphology	J:82809, J:89093
	abnormal stapes head morphology	J:89093
	absent incus lenticular process	J:89093
	absent pinna reflex	J:89093
	normal cardiovascular system phenotype	J:89093
	conductive hearing loss	J:82809
	deafness	J:89093
	decreased cochlear nerve compound action potential	J:89093
	increased cochlear inner hair cell number	J:82809, J:89093
	increased cochlear outer hair cell number	J:82809, J:89093
	sensorineural hearing loss	J:82809
	syndromic hearing loss	J:82809
Emx2^Pdo/Emx2^Pdo involves: BALB/c * C3H/HeN	abnormal malleus morphology	J:89093
	abnormal stapes head morphology	J:89093
	absent incus	J:89093
	neonatal lethality, complete penetrance	J:89093
	small kidney	J:89093
Emx2^Pdo/Emx2^tm1Pgr involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6	absent incus	J:89093
	neonatal lethality, complete penetrance	J:89093
	small kidney	J:89093
Emx2^tm1Pgr/Emx2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal incudomalleolar joint morphology	J:37631
	abnormal malleus morphology	J:89093
	abnormal stapes morphology	J:37631
	absent incus	J:37631, J:89093
	increased cochlear inner hair cell number	J:89093
	increased cochlear outer hair cell number	J:89093
Emx2^tm1Pgr/Emx2^tm1Pgr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal Ammon gyrus morphology	J:37631
	abnormal cerebral cortex morphology	J:37631
	abnormal cerebral hemisphere morphology	J:37631
	abnormal hippocampal fimbria morphology	J:37631
	abnormal lateral ventricle morphology	J:37631
	absent dentate gyrus	J:37631
	absent kidney	J:37631
	decreased anterior commissure size	J:37631
	decreased corpus callosum size	J:37631
	decreased hippocampal fornix size	J:37631
	dilated third ventricle	J:37631
	neonatal lethality, complete penetrance	J:37631
	small olfactory bulb	J:37631
Emx2^tm1Sia/Emx2^tm1Sia involves: C57BL/6 * CBA	abnormal kidney development	J:40605
	abnormal metanephric mesenchyme morphology	J:40605
	abnormal metanephric ureteric bud development	J:40605
	abnormal pallium development	J:163926
	abnormal primary sex determination	J:40605
	abnormal ureteric bud tip morphology	J:40605
	absent cranial vagina	J:40605
	absent dentate gyrus	J:163926
	absent efferent ductules of testis	J:40605
	absent epididymis	J:40605
	absent internal female genitalia	J:40605
	absent internal male genitalia	J:40605
	absent kidney	J:40605
	absent Mullerian ducts	J:40605
	absent ovary	J:40605
	absent oviduct	J:40605
	absent seminal vesicle	J:40605
	absent testes	J:40605
	absent ureter	J:40605
	absent uterus	J:40605
	absent vas deferens	J:40605
	agonadal	J:40605
	gonadal ridge hypoplasia	J:40605
	impaired branching involved in ureteric bud morphogenesis	J:40605
	increased metanephric mesenchyme apoptosis	J:40605
	neonatal lethality, complete penetrance	J:40605
	Wolffian duct degeneration	J:40605
Emx2^tm2(cre)Sia/Emx2^tm2(cre)Sia involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal vestibular hair cell morphology	J:338146
Emx2^wndr/Emx2^wndr Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N	abnormal axon extension	J:168258
	abnormal cerebral cortex morphology	J:168258
	neonatal lethality, complete penetrance	J:168258
	renal hypoplasia	J:168258
	small olfactory bulb	J:168258

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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