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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Emx2
empty spiracles homeobox 2
MGI:95388
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2+
involves: C57BL/6 * CBA 		abnormal cerebral cortex morphology J:163926
abnormal embryonic/fetal subventricular zone morphology J:163926
Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2tm1Sia
involves: C57BL/6 * CBA 		abnormal pallium development J:163926
absent dentate gyrus J:163926
absent hippocampal fimbria J:163926
absent hippocampus J:163926
Emx2tm1Sia/Emx2+
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal forebrain morphology J:70745
Emx2tm1Sia/Emx2tm1Sia
Otx1tm1Sia/Otx1tm1Sia
involves: C57BL/6 * CBA 		abnormal Ammon gyrus morphology J:98539
abnormal cerebral cortex morphology J:98539
abnormal forebrain morphology J:98539
abnormal hippocampus morphology J:98539
abnormal pretectal region morphology J:98539
abnormal telencephalon morphology J:98539
small thalamus J:98539
Emx2tm1Sia/Emx2tm1Sia
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA 		abnormal adenohypophysis morphology J:70745
abnormal Ammon gyrus morphology J:70745
abnormal anterior commissure morphology J:70745
abnormal cerebral cortex morphology J:70745, J:98539
abnormal corpus callosum morphology J:70745
abnormal forebrain development J:163926
abnormal forebrain morphology J:70745
abnormal hippocampal fornix morphology J:70745
abnormal hippocampus region morphology J:70745
abnormal lateral ganglionic eminence morphology J:70745
abnormal lens morphology J:70745
abnormal medial ganglionic eminence morphology J:70745
abnormal midbrain morphology J:70745
abnormal midbrain-hindbrain boundary morphology J:70745
abnormal olfactory bulb mitral cell layer morphology J:70745
abnormal olfactory sensory neuron morphology J:70745
abnormal posterior commissure morphology J:70745
abnormal pretectal region morphology J:70745
abnormal telencephalon morphology J:70745, J:98539
abnormal thalamus morphology J:70745
absent choroid plexus J:70745, J:98539
absent dentate gyrus J:70745
absent hippocampal fimbria J:70745
absent hippocampus J:70745, J:98539
enlarged tectum J:70745
lethality throughout fetal growth and development, complete penetrance J:70745
retina hyperplasia J:70745
small olfactory bulb J:70745
Emx2tm1Sia/Emx2tm1Sia
Otx2tm7Sia/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj 		absent diencephalon J:91012
Emx2tm1Sia/Emx2tm1Sia
Pax6Sey/Pax6Sey
involves: C57BL/6 * CBA 		abnormal Ammon gyrus morphology J:98539
abnormal brain commissure morphology J:98539
abnormal brain morphology J:98539
abnormal cerebral cortex morphology J:98539
abnormal embryonic/fetal subventricular zone morphology J:98539
abnormal pretectal region morphology J:98539
abnormal tectum morphology J:98539
abnormal telencephalon morphology J:98539
abnormal thalamus morphology J:98539
absent choroid plexus J:98539
absent diencephalon J:98539
absent hippocampus J:98539
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Emx2tm2(cre)Sia/Emx2+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal astrocyte morphology J:188109
abnormal cerebral cortex morphology J:188109
abnormal cortical plate morphology J:188109
abnormal nervous system development J:188109
abnormal neuron differentiation J:188109
abnormal neuronal precursor proliferation J:188109
abnormal telencephalon development J:188109
decreased neuron number J:188109
decreased neuronal precursor cell number J:188109
increased neuron apoptosis J:188109
increased neuron number J:188109
loss of cortex neurons J:188109
postnatal lethality, complete penetrance J:188109
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory