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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		En1
engrailed 1
MGI:95389
115 phenotypes from 15 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
En1em1Smun/En1em1Smun
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 		abnormal rib morphology J:306235
decreased sternebra size J:306235
polydactyly J:306235
short sternum J:306235
syndactyly J:306235
En1tm1(Otx2)Wrst/En1+
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal brain commissure morphology J:57538
abnormal brain morphology J:57538
abnormal cerebellar lobule formation J:57538
abnormal cerebellum morphology J:57538
abnormal cerebellum vermis morphology J:57538
abnormal corpora quadrigemina morphology J:57538
abnormal gait J:57538
abnormal locomotor coordination J:57538
absent cerebellar lobules J:57538
ataxia J:57538
decreased anterior vermis size J:57538
impaired coordination J:57538
increased inferior colliculus size J:57538
increased superior colliculus size J:57538
En1tm1(Otx2)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		abnormal neuron morphology J:88192
abnormal serotonergic neuron morphology J:88192
decreased serotonin level J:88192
ectopic dopaminergic neuron J:88192
increased dopamine level J:88192
increased locomotor activity J:88192
En1tm1(PDGFB)Nist/En1+
involves: 129/Sv * C57BL/6 		abnormal brain vasculature morphology J:90898
abnormal cell migration J:90898
abnormal cerebellum development J:90898
normal behavior/neurological phenotype J:90898
En1tm1(PDGFB)Nist/En1tm1(PDGFB)Nist
involves: 129/Sv * C57BL/6 		neonatal lethality, complete penetrance J:90898
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit
involves: C57BL/6 		decreased physiological sensitivity to xenobiotic J:170743
normal nervous system phenotype J:170743
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit
involves: C57BL/6 		abnormal dopaminergic neuron morphology J:170743
astrocytosis J:170743
decreased neuron number J:170743
increased monocyte cell number J:170743
microgliosis J:170743
neuron degeneration J:170743
En1tm1(Wnt1)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell cycle J:91004
abnormal cerebellum morphology J:91004
abnormal hindbrain morphology J:91004
increased cell proliferation J:91004
increased inferior colliculus size J:91004
En1tm1(Wnt1)Wrst/En1tm1(Wnt1)Wrst
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		increased inferior colliculus size J:91004
neonatal lethality, complete penetrance J:91004
En1tm1Alj/En1tm1Alj
B6.129-En1tm1Alj 		abnormal autopod morphology J:84363
abnormal cerebellar lobule formation J:84363
abnormal digit morphology J:84363
decreased body size J:84363
decreased inferior colliculus size J:84363
deformed nails J:84363
polydactyly J:84363
postnatal lethality, incomplete penetrance J:84363
syndactyly J:84363
En1tm1Alj/En1tm1Alj
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal autopod morphology J:34307
abnormal axial skeleton morphology J:19212
abnormal brain development J:19212
abnormal brain morphology J:19212
abnormal cerebellum morphology J:19212
abnormal choroid plexus morphology J:19212
abnormal cranial nerve morphology J:19212
abnormal digit morphology J:19212, J:34307
abnormal eccrine sweat gland morphology J:34307
abnormal foot pad morphology J:34307
abnormal hair follicle dermal papilla morphology J:34307
abnormal hair follicle development J:34307
abnormal limb morphology J:34307
abnormal midbrain development J:19212
abnormal nail morphology J:34307
abnormal suckling behavior J:19212
absent cerebellum J:19212
absent oculomotor nerve J:19212
absent trochlear nerve J:19212
aphagia J:19212
decreased inferior colliculus size J:19212
decreased rib number J:19212
delayed bone ossification J:19212
ectopic digits J:34307
neonatal lethality, complete penetrance J:19212
polydactyly J:19212
short sternum J:19212
syndactyly J:19212
thin apical ectodermal ridge J:34307
truncated digits J:19212
wrinkled skin J:19212
En1tm1Alj/En1tm1Alj
involves: 129 * C57BL/6J 		abnormal apical ectodermal ridge morphology J:45301
En1tm1Alj/En1tm1Alj
Tg(Wnt1-En1)1Amc/0
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal brain morphology J:45301
abnormal digit morphology J:45301
abnormal foot pad morphology J:45301
neonatal lethality J:45301
En1tm1Gld/En1tm1Gld
involves: 129S/SvEv 		abnormal CNS synaptic transmission J:106437
En1tm1Gld/En1tm1Gld
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster 		decreased dopaminergic neuron number J:115270
perinatal lethality, complete penetrance J:115270
En1tm1Gld/En1tm1Gld
involves: 129S/SvEv * C57BL/6 		abnormal axon guidance J:52637
abnormal innervation J:52637
abnormal limb morphology J:52637
abnormal neuron differentiation J:52637
decreased midbrain size J:52637
En1tm1Gld/En1tm1Gld
Tg(Wnt1-En1)1Amc/0
involves: 129S/SvEv 		impaired coordination J:106437
En1tm2(cre)Gld/En1tm2(cre)Gld
involves: 129S1/Sv 		abnormal synapse morphology J:87771
perinatal lethality, incomplete penetrance J:87771
En1tm2(cre)Wrst/En1tm8.1Alj
involves: 129/Sv * Black Swiss * C57BL/6 * SJL 		abnormal cerebellum anterior vermis morphology J:134516
abnormal inferior colliculus morphology J:134516
decreased anterior vermis size J:134516
En1tm2Alj/En1+
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		normal nervous system phenotype J:134516
En1tm2Alj/En1+
Tg(Th-EGFP)6-7Okn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J * OF1 		abnormal autophagy J:214073
abnormal synaptic dopamine release J:214073
axon degeneration J:214073
axonal dystrophy J:214073
axonal spheroids J:214073
decreased dopamine level J:214073
decreased dopaminergic neuron number J:214073
neurodegeneration J:214073
En1tm2Alj/En1tm2Alj
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal cerebellum morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
absent inferior colliculus J:134516
decreased midbrain size J:134516
decreased rhombomere 1 size J:134516
decreased superior colliculus size J:134516
En1tm4(en)Alj/En1tm4(en)Alj
involves: 129S1/Sv * 129X1/SvJ 		abnormal brain morphology J:50311
abnormal cerebellum development J:50311
abnormal digit morphology J:50311
abnormal digit pigmentation J:50311
abnormal fertility/fecundity J:50311
abnormal sternebra morphology J:50311
abnormal sternum ossification J:50311
asymmetric sternocostal joints J:50311
decreased inferior colliculus size J:50311
deformed nails J:50311
male infertility J:50311
polydactyly J:50311
premature death J:50311
syndactyly J:50311
En1tm5(en)Alj/En1tm5(en)Alj
involves: 129S1/Sv * 129X1/SvJ 		abnormal brain morphology J:50311
abnormal cerebellar lobule formation J:50311
abnormal digit morphology J:34307, J:50311
abnormal digit pigmentation J:50311
abnormal eccrine sweat gland morphology J:34307
abnormal foot pad morphology J:34307
abnormal hair follicle development J:34307
abnormal limb bone morphology J:34307
abnormal nail morphology J:34307
decreased midbrain size J:50311
deformed nails J:50311
fused phalanges J:34307
polydactyly J:50311
premature death J:50311
normal skeleton phenotype J:50311
syndactyly J:50311
En1tm5(en)Alj/En1tm5(en)Alj
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		normal mortality/aging J:134516
normal nervous system phenotype J:134516
Tg(Msx2-En1)86Alj/0
involves: Swiss Webster 		abnormal autopod morphology J:62572
abnormal digit development J:62572
abnormal forelimb morphology J:62572
abnormal hindlimb morphology J:62572
abnormal limb morphology J:62572
abnormal ulna morphology J:62572
absent ulna J:62572
adactyly J:62572
bowed radius J:62572
ectopic digits J:62572
polydactyly J:62572
short ulna J:62572
Tg(Msx2-En1)86Alj/Tg(Msx2-En1)86Alj
involves: Swiss Webster 		abnormal digit morphology J:62572
abnormal femur morphology J:62572
abnormal forelimb morphology J:62572
abnormal hindlimb morphology J:62572
abnormal limb morphology J:62572
absent fibula J:62572
absent hindlimb J:62572
adactyly J:62572
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory