En2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

En2
engrailed 2
MGI:95390

31 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
En2^tm1Alj/En2⁺ either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)	abnormal behavior	J:31921
En2^tm1Alj/En2^tm1Alj either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)	abnormal cerebellar foliation	J:31921, J:67524
	abnormal cerebellum development	J:67524
	abnormal cerebellum posterior vermis morphology	J:31921
	abnormal cerebellum vermis morphology	J:67524
	abnormal locomotor activation	J:31921
	impaired coordination	J:31921
	increased defecation amount	J:31921
	small cerebellum	J:31921, J:67524
En2^tm1Alj/En2^tm1Alj involves: 129/Sv * 129S2/SvPas	abnormal cerebellar foliation	J:17203
	abnormal cerebellar granule layer morphology	J:17203
	abnormal cerebellum development	J:17203
	abnormal cerebellum morphology	J:17203
	abnormal cerebellum posterior vermis morphology	J:17203
	decreased colliculi size	J:17203
	thin external granule cell layer	J:17203
En2^tm1Alj/En2^tm1Alj involves: 129S2/SvPas * C57BL/6	abnormal grip strength	J:114464
	abnormal grooming behavior	J:114464
	abnormal motor capabilities/coordination/movement	J:114464
	abnormal motor coordination/balance	J:114464
	abnormal social investigation	J:114464
	abnormal social/conspecific interaction behavior	J:114464
	abnormal spatial learning	J:114464
	decreased aggression towards mice	J:114464
	decreased grooming behavior	J:114464
	hyperactivity	J:114464
	impaired coordination	J:114464
	impaired righting response	J:114464
	increased grooming behavior	J:114464
	increased serotonin level	J:114464
En2^tm1Alj/En2^tm6Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum hemisphere lobule morphology	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
En2^tm2Alj/En2^tm2Alj involves: 129S2/SvPas * C57BL/6	abnormal cerebellar foliation	J:17203
	abnormal cerebellum development	J:17203
	abnormal cerebellum posterior vermis morphology	J:17203
	small cerebellum	J:17203
En2^tm2Alj/En2^tm2Alj involves: 129S2/SvPas * Swiss Webster	abnormal cerebellum morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	abnormal cerebellum vermis morphology	J:134516
	decreased inferior colliculus size	J:134516
	small cerebellum	J:134516
En2^tm2Alj/En2^tm3Alj involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	normal nervous system phenotype	J:60433
En2^tm3.1Alj/En2^tm3.1Alj involves: 129S6/SvEvTac	normal nervous system phenotype	J:60433
En2^tm3Alj/En2^tm3Alj involves: 129S6/SvEvTac	normal nervous system phenotype	J:60433
En2^tm5.1Alj/En2^tm5.1Alj involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	reduced fertility	J:134516
En2^tm5.1Alj/En2^tm5.1Alj involves: 129S6/SvEvTac * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum hemisphere lobule morphology	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
En2^tm5.1Alj/En2^tm5.1Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S2/SvPas * Swiss Webster	normal nervous system phenotype	J:156169

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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