En2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

En2
engrailed 2
MGI:95390

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
En1^tm1Alj/En1⁺ En2^tm1Alj/En2^tm1Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	normal nervous system phenotype	J:84363
En1^tm1Alj/En1^tm1Alj En2^tm1Alj/En2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	absent cerebellum	J:84363
En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm6Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellar granule cell precursor proliferation	J:156169
	abnormal cerebellum development	J:156169
	abnormal cerebellum external granule cell layer morphology	J:156169
	abnormal cerebellum fissure morphology	J:156169
	abnormal cerebellum morphology	J:156169
	abnormal cerebellum posterior vermis morphology	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
	abnormal cerebellum vermis morphology	J:156169
	abnormal midbrain morphology	J:156169
	cerebellum vermis hypoplasia	J:156169
	decreased anterior vermis size	J:156169
	perinatal lethality, complete penetrance	J:156169
	small cerebellum	J:156169
	thin external granule cell layer	J:156169
En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum hemisphere lobule morphology	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum hemisphere lobule morphology	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
En1^tm1Alj/En1^tm8.1Alj En2^tm6Alj/En2⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum vermis lobule morphology	J:156169
	decreased anterior vermis size	J:156169
En1^tm1Gld/En1⁺ En2^tm1Alj/En2^tm1Alj involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster	abnormal behavior	J:115270
	decreased dopamine level	J:115270
	decreased food intake	J:115270
	decreased grip strength	J:115270
	decreased locomotor activity	J:115270
	decreased neurotransmitter release	J:115270
	loss of dopaminergic neurons	J:115270
	slow postnatal weight gain	J:115270
En1^tm1Gld/En1^tm1Gld En2^tm1Alj/En2⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster	decreased dopaminergic neuron number	J:115270
	perinatal lethality, complete penetrance	J:115270
En1^tm1Gld/En1^tm1Gld En2^tm1Alj/En2^tm1Alj involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster	decreased dopaminergic neuron number	J:115270
	perinatal lethality, complete penetrance	J:115270
En1^tm2(cre)Wrst/En1^tm8.1Alj En2^tm2Alj/En2⁺ involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster	absent cerebellum	J:134516
	absent inferior colliculus	J:134516
	decreased superior colliculus size	J:134516
En1^tm2(cre)Wrst/En1^tm8.1Alj En2^tm2Alj/En2^tm2Alj involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster	absent cerebellum	J:134516
	absent colliculi	J:134516
	absent inferior colliculus	J:134516
	absent superior colliculus	J:134516
	absent tectum	J:134516
En1^tm2Alj/En1⁺ En2^tm2Alj/En2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:134516
	abnormal cerebellum anterior vermis morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	abnormal cerebellum vermis morphology	J:134516
	small cerebellum	J:134516
En1^tm2Alj/En1⁺ En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:134516
	abnormal cerebellum anterior vermis morphology	J:134516
	abnormal cerebellum morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	abnormal tectum morphology	J:134516
	absent cerebellum	J:134516
	absent cerebellum vermis	J:134516
	absent inferior colliculus	J:134516
	decreased inferior colliculus size	J:134516
	normal mortality/aging	J:134516
	small cerebellum	J:134516
	small tectum	J:134516
En1^tm2Alj/En1^tm2Alj En2^tm2Alj/En2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	absent cerebellum	J:134516
	absent colliculi	J:134516
	absent inferior colliculus	J:134516
	absent superior colliculus	J:134516
	absent tectum	J:134516
	perinatal lethality, complete penetrance	J:134516
En1^tm2Alj/En1^tm2Alj En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal midbrain-hindbrain boundary development	J:66592
	absent colliculi	J:134516
	absent inferior colliculus	J:134516
	absent midbrain	J:66592
	absent midbrain-hindbrain boundary	J:66592
	absent rhombomere 1	J:66592
	absent superior colliculus	J:134516
	absent tectum	J:134516
	decreased rhombomere 1 size	J:66592
	small cerebellum	J:134516
En1^tm2Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:134516
	abnormal cerebellum morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	decreased inferior colliculus size	J:134516
	small cerebellum	J:134516
En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	normal nervous system phenotype	J:134516
En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:134516
	abnormal cerebellum morphology	J:134516
	normal mortality/aging	J:134516
	small cerebellum	J:134516
En1^tm5(en)Alj/En1⁺ En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:134516
	abnormal cerebellum morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	decreased inferior colliculus size	J:134516
	small cerebellum	J:134516
En1^tm5(en)Alj/En1^tm5(en)Alj En2^tm2Alj/En2⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	abnormal cerebellum anterior vermis morphology	J:134516
	abnormal cerebellum posterior vermis morphology	J:134516
	decreased inferior colliculus size	J:134516
	decreased survivor rate	J:134516
	small cerebellum	J:134516
En1^tm5(en)Alj/En1^tm5(en)Alj En2^tm2Alj/En2^tm2Alj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	absent cerebellum	J:134516
	absent inferior colliculus	J:134516
	absent superior colliculus	J:134516
	decreased superior colliculus size	J:134516
	perinatal lethality, complete penetrance	J:134516
En1^{tm7(cre/ESR1)Alj}/En1⁺ En2^tm2Alj/En2^tm2Alj Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellum morphology	J:134516
	abnormal cerebellum vermis morphology	J:134516
	abnormal tectum morphology	J:134516
	decreased midbrain size	J:134516
	decreased rhombomere 1 size	J:134516
En1^tm8.1Alj/En1⁺ En2^tm6Alj/En2⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * Swiss Webster	abnormal cerebellar foliation	J:156169
	abnormal cerebellum fissure morphology	J:156169
	abnormal cerebellum posterior vermis morphology	J:156169

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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