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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Eng
endoglin
MGI:95392
68 phenotypes from 7 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Engem1(IMPC)Mbp/Eng+
C57BL/6N-Engem1(IMPC)Mbp/MbpMmucd 		abnormal caudal vertebrae morphology J:211773
abnormal kidney morphology J:211773
abnormal placenta morphology J:211773
increased neutrophil cell number J:211773
small kidney J:211773
Engem1(IMPC)Mbp/Engem1(IMPC)Mbp
C57BL/6N-Engem1(IMPC)Mbp/MbpMmucd 		abnormal heart morphology J:211773
abnormal neural tube morphology J:211773
abnormal pharyngeal arch morphology J:211773
abnormal somite shape J:211773
abnormal visceral yolk sac morphology J:211773
abnormal vitelline vasculature morphology J:211773
embryonic growth retardation J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
EngGt(Betageo)1Jrt/EngGt(Betageo)1Jrt
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) 		no abnormal phenotype detected J:92259
Engtm1Dyl/Engtm1Dyl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal carotid artery morphology J:55403
abnormal dorsal aorta morphology J:55403
abnormal intersomitic vessel morphology J:55403
abnormal perineural vascular plexus morphology J:55403
abnormal vascular development J:55403
abnormal vascular smooth muscle morphology J:55403
abnormal vitelline vasculature morphology J:55403
blood vessel atresia J:55403
decreased angiogenesis J:55403
decreased embryo size J:55403
embryonic lethality during organogenesis, complete penetrance J:55403
failure of heart looping J:55403
incomplete somite formation J:55403
pericardial effusion J:55403
Engtm1Hma/Eng+
129P2/OlaHsd-Engtm1Hma 		abnormal blood vessel morphology J:73415
abnormal vascular smooth muscle morphology J:73415
Engtm1Hma/Engtm1Hma
involves: 129P2/OlaHsd 		abnormal vascular smooth muscle morphology J:98373
Engtm1Hma/Engtm1Hma
involves: 129P2/OlaHsd * C57BL/6J 		abnormal capillary morphology J:73415
abnormal cardiac outflow tract development J:73415
abnormal dorsal aorta morphology J:73415
abnormal embryonic hematopoiesis J:73415
abnormal heart development J:73415
abnormal heart looping J:73415
abnormal vitelline vasculature morphology J:73415
anemia J:73415
decreased embryo size J:73415
embryonic growth retardation J:73415
embryonic lethality during organogenesis, complete penetrance J:73415
increased heart ventricle size J:73415
pericardial effusion J:73415
thin myocardium J:73415
Engtm1Hma/Engtm2.1Hma
involves: 129P2/OlaHsd * C57BL/6 		normal mortality/aging J:121898
Engtm1Mle/Eng+
129P2/OlaHsd-Engtm1Mle 		ear telangiectasia J:58502
hemorrhage J:58502
premature death J:58502
tail telangiectasia J:58502
Engtm1Mle/Eng+
involves: 129P2/OlaHsd * C57BL/6 		ear telangiectasia J:58502
hemorrhage J:58502
internal hemorrhage J:58502
neck telangiectasia J:58502
respiratory distress J:58502
ruffled hair J:58502
tail telangiectasia J:58502
weight loss J:58502
Engtm1Mle/Eng+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		normal cardiovascular system phenotype J:58502
Engtm1Mle/Engtm1Mle
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood vessel morphology J:58502
abnormal craniofacial development J:58502
abnormal endocardium morphology J:58502
abnormal heart development J:58502
abnormal pharyngeal arch morphology J:58502
abnormal visceral yolk sac blood island morphology J:58502
abnormal vitelline vasculature morphology J:58502
absent heartbeat J:58502
absent vitelline blood vessels J:58502
embryo tissue necrosis J:58502
embryonic growth retardation J:58502
embryonic lethality during organogenesis, complete penetrance J:58502
enlarged heart J:58502
hemoperitoneum J:58502
microcephaly J:58502
pericardial edema J:58502
Engtm2.1Hma/Engtm2.1Hma
involves: 129P2/OlaHsd 		cerebral arteriovenous malformation J:196810
Engtm2.1Hma/Engtm2.1Hma
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:121898
Engtm2.1Hma/Engtm2.1Hma
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal vascular wound healing J:212952, J:227170
arteriovenous malformation J:212952, J:227170
decreased locomotor activity J:227170
dehydration J:227170
diarrhea J:227170
hemorrhage J:212952
moribund J:227170
Engtm2.1Hma/Engtm2.1Hma
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd 		normal cardiovascular system phenotype J:212952
Engtm2.1Hma/Engtm2.1Hma
Tg(Myh11-icre/ERT2)1Soff/0
involves: 129P2/OlaHsd * FVB/N 		normal cardiovascular system phenotype J:227170
Engtm2.1Hma/Engtm2.1Hma
Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal blood vessel morphology J:212952
arteriovenous malformation J:212952
gastrointestinal arteriovenous malformation J:212952
hemorrhage J:212952
premature death J:212952
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal vascular wound healing J:227170
arteriovenous malformation J:227170
Engtm2.2Hma/Engtm2.2Hma
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal embryo development J:121898
abnormal vitelline vasculature morphology J:121898
prenatal lethality, complete penetrance J:121898
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory