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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
MGI:95412
74 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ercc1tm1Dwm/Ercc1+
involves: 129P2/OlaHsd * BALB/c 		abnormal liver physiology J:15422
decreased liver function J:15422
Ercc1tm1Dwm/Ercc1tm1Dwm
involves: 129P2/OlaHsd * BALB/c 		abnormal cell nucleus morphology J:15422
aneuploidy J:15422
decreased birth body size J:15422
decreased liver function J:15422
liver degeneration J:15422
polyploidy J:15422
postnatal lethality, complete penetrance J:15422
Ercc1tm1Dwm/Ercc1tm1Dwm
Tg(Ttr-Ercc1)17Dwm/0
involves: 129P2/OlaHsd * BALB/c 		abnormal chromosome number J:106084
abnormal gametogenesis J:80586
abnormal male germ cell apoptosis J:80586
abnormal ovarian folliculogenesis J:80586
abnormal renal tubule morphology J:106084
abnormal spermatogenesis J:80586
absent primary ovarian follicles J:80586
decreased germ cell number J:80586
female infertility J:80586
increased circulating lactate level J:106084
kidney failure J:106084
male infertility J:80586
polyploidy J:106084
premature death J:106084
Ercc1tm1Jhjh/Ercc1tm1Jhjh
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) 		decreased body size J:41161
embryonic growth retardation J:41161
embryonic lethality during organogenesis, incomplete penetrance J:41161
premature death J:41161
Ercc1tm1Jhjh/Ercc1tm1Jhjh
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal DNA repair J:117488
abnormal kidney physiology J:117488
abnormal postnatal growth J:117488
acidosis J:117488
ataxia J:117488
decreased bone mineral density J:117488
decreased cell proliferation J:117488
decreased circulating glucose level J:117488
decreased circulating insulin level J:117488
decreased circulating insulin-like growth factor I level J:117488
decreased hepatocyte proliferation J:117488
decreased skeletal muscle mass J:117488
dystonia J:117488
early cellular replicative senescence J:117488
embryonic growth retardation J:117488
fetal growth retardation J:117488
hepatic steatosis J:117488
increased cellular sensitivity to oxidative stress J:117488
increased hepatocyte apoptosis J:117488
increased liver triglyceride level J:117488
increased urine protein level J:117488
kyphosis J:117488
postnatal growth retardation J:117488
postnatal lethality, incomplete penetrance J:117488
premature aging J:117488
Ercc1tm1Jhjh/Ercc1tm1Jhjh
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal hepatocyte morphology J:206925
decreased body size J:206925
decreased body weight J:206925
decreased common myeloid progenitor cell number J:206925
decreased erythroid progenitor cell number J:206925
decreased granulocyte monocyte progenitor cell number J:206925
decreased hematopoietic stem cell number J:206925
decreased megakaryocyte-erythroid progenitor cell number J:206925
premature death J:206925
Ercc1tm1Jhjh/Ercc1tm1Jhjh
involves: C57BL/6 * FVB/N 		abnormal class switch recombination J:92471
abnormal liver physiology J:92471
decreased B cell proliferation J:92471
lethality at weaning, complete penetrance J:92471
spleen hypoplasia J:92471
Ercc1tm1Jhjh/Ercc1tm2Jhjh
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal hepatocyte morphology J:206925
decreased body weight J:206925
decreased common myeloid progenitor cell number J:206925
decreased erythroid progenitor cell number J:206925
decreased granulocyte monocyte progenitor cell number J:206925
decreased hematopoietic stem cell number J:206925
decreased megakaryocyte-erythroid progenitor cell number J:206925
Ercc1tm1Jhjh/Ercc1tm2Jhjh
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal distortion product otoacoustic emission J:280844
abnormal optokinetic reflex J:280844
cochlear hair cell degeneration J:280844
impaired hearing J:280844
increased or absent threshold for auditory brainstem response J:280844
increased retina apoptosis J:280844
thin retina outer nuclear layer J:280844
Ercc1tm1Jhjh/Ercc1tm3Jhjh
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N 		normal hematopoietic system phenotype J:206925
Ercc1tm2Jhjh/Ercc1tm2Jhjh
involves: 129P2/OlaHsd * C57BL/6 		abnormal hepatocyte morphology J:41161
abnormal spleen morphology J:41161
decreased body size J:41161
decreased cell proliferation J:41161
decreased subcutaneous adipose tissue amount J:41161
dilated renal tubule J:41161
embryonic lethality during organogenesis, incomplete penetrance J:41161
increased physiological sensitivity to xenobiotic J:41161
increased susceptibility to xenobiotic induced morbidity/mortality J:41161
infertility J:41161
premature death J:41161
thin skin J:41161
Ercc1tm2Jhjh/Ercc1tm2Jhjh
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal hepatocyte morphology J:206925
decreased body weight J:206925
decreased common myeloid progenitor cell number J:206925
decreased erythroid progenitor cell number J:206925
decreased granulocyte monocyte progenitor cell number J:206925
decreased hematopoietic stem cell number J:206925
decreased megakaryocyte-erythroid progenitor cell number J:206925
Ercc1tm2Jhjh/Ercc1tm2Jhjh
involves: 129P2/OlaHsd * FVB 		decreased body size J:41161
premature death J:41161
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory