Ercc2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
MGI:95413

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Ercc3^tm2Jhjh/Ercc3^tm2Jhjh involves: 129P2/OlaHsd * C57BL/6	increased cellular sensitivity to gamma-irradiation	J:145759
	increased cellular sensitivity to oxidative stress	J:145759
	increased cellular sensitivity to ultraviolet irradiation	J:145759
	postnatal growth retardation	J:145759
	postnatal lethality, complete penetrance	J:145759
Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6	abnormal adipose tissue distribution	J:76608
	abnormal cell death	J:76608
	abnormal gait	J:76608
	cachexia	J:76608
	dilated hair follicle	J:76608
	hyperkeratosis	J:76608
	increased cellular sensitivity to oxidative stress	J:76608
	increased cellular sensitivity to ultraviolet irradiation	J:76608
	increased cellular sensitivity to X-ray irradiation	J:76608
	kyphosis	J:76608
	neonatal lethality, incomplete penetrance	J:76608
	osteoporosis	J:76608
	postnatal growth retardation	J:76608
	postnatal lethality, complete penetrance	J:76608
	premature aging	J:76608
Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6 * FVB	ataxia	J:112689
	impaired balance	J:112689
	postnatal growth retardation	J:112689
	postnatal lethality, complete penetrance	J:112689
	Purkinje cell degeneration	J:112689
	tremors	J:112689

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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