Ets1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ets1
E26 avian leukemia oncogene 1, 5' domain
MGI:95455

55 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ets1^m1Anu/Ets1^m1Anu C57BL/6NCrlAnu-Ets1^m1Anu	normal immune system phenotype	J:104190
Ets1^tm1.1Dds/Ets1⁺ 129S6/SvEvTac-Ets1^tm1.1Dds	abnormal thymus morphology	J:121460
	decreased memory T cell number	J:121460
	decreased thymocyte apoptosis	J:121460
	enlarged thymus	J:121460
	increased splenocyte apoptosis	J:121460
	increased thymus weight	J:121460
Ets1^tm1.1Dds/Ets1^tm1.1Dds 129S6/SvEvTac-Ets1^tm1.1Dds	abnormal CD8-positive, alpha beta T cell morphology	J:121460
	abnormal lymphopoiesis	J:121460
	abnormal spleen morphology	J:121460
	abnormal spleen red pulp morphology	J:121460
	abnormal thymus cortex morphology	J:121460
	abnormal thymus morphology	J:121460
	abnormal thymus subcapsular epithelium morphology	J:121460
	decreased B cell number	J:121460
	decreased CD4-positive, alpha-beta T cell number	J:121460
	decreased leukocyte cell number	J:121460
	decreased memory T cell number	J:121460
	decreased spleen weight	J:121460
	decreased thymocyte apoptosis	J:121460
	enlarged thymus	J:121460
	increased cell proliferation	J:121460
	increased double-positive T cell number	J:121460
	increased splenocyte apoptosis	J:121460
	increased thymus weight	J:121460
	perinatal lethality, incomplete penetrance	J:121460
	prenatal lethality, incomplete penetrance	J:121460
	small spleen	J:121460
Ets1^tm1Fwa/Ets1^tm1Fwa B6.129S4-Ets1^tm1Fwa	abnormal B cell differentiation	J:93845
	absent B-1a cells	J:93845
	decreased B cell number	J:93845
	decreased B cell proliferation	J:93845
	decreased body weight	J:93454, J:93845
	decreased mature B cell number	J:93845
	decreased pro-B cell number	J:93845
	normal immune system phenotype	J:93845
	increased B cell apoptosis	J:93845
	increased pro-B cell number	J:93845
	postnatal growth retardation	J:93454, J:93845
	postnatal lethality, incomplete penetrance	J:93454, J:93845
Ets1^tm1Jml/Ets1^tm1Jml involves: 129S/SvEv * C57BL/6	abnormal CD8-positive, alpha-beta T cell differentiation	J:125056
	decreased CD4-positive, alpha-beta T cell number	J:125056
	decreased CD8-positive, alpha-beta T cell number	J:125056
	increased double-negative T cell number	J:125056
	thymus hypoplasia	J:125056
Ets1^tm1Most/Ets1^tm1Most Pax3^tm1(cre)Joe/Pax3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	double outlet right ventricle	J:334073
Ets1^tm2Jml/Ets1⁺ involves: 129X1/SvJ * C57BL/6J	belly spot	J:334073
Ets1^tm2Jml/Ets1^tm2Jml involves: 129X1/SvJ * C57BL/6	abnormal CD8-positive, alpha beta T cell morphology	J:50627
	abnormal leukocyte physiology	J:50627
	abnormal NK cell physiology	J:50627
	abnormal T cell activation	J:50627
	decreased NK cell number	J:50627
	decreased T cell number	J:50627
	decreased T cell proliferation	J:50627
	decreased thymocyte number	J:50627
	normal hematopoietic system phenotype	J:50627
	impaired natural killer cell mediated cytotoxicity	J:50627
	increased plasma cell number	J:50627
	perinatal lethality, incomplete penetrance	J:50627
	postnatal lethality, incomplete penetrance	J:50627
Ets1^tm2Jml/Ets1^tm2Jml involves: 129X1/SvJ * C57BL/6J	abnormal cardiac outflow tract development	J:334073
	abnormal heart right ventricle outflow tract morphology	J:334073
	bicuspid aortic valve	J:334073
	decreased cardiac neural crest cell number	J:334073
	double outlet right ventricle	J:334073
	overriding aortic valve	J:334073
Ets1^vs/Ets1^vs C3HeB/FeJ-Ets1^vs/J	belly spot	J:14217
	head blaze	J:14217
	white spotting	J:14217

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