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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mecom
MDS1 and EVI1 complex locus
MGI:95457
125 phenotypes from 9 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mecomem1(IMPC)J/Mecom+
C57BL/6NJ-Mecomem1(IMPC)J/Mmjax 		thrombocytopenia J:211773
Mecomem1(IMPC)J/Mecomem1(IMPC)J
C57BL/6NJ-Mecomem1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
MecomJbo/Mecom+
C3N.C-MecomJbo 		abnormal craniofacial morphology J:90559
abnormal neutrophil differentiation J:113445
abnormal tympanic membrane morphology J:113445
deafness J:90559, J:113445
decreased body weight J:90559
normal immune system phenotype J:113445
increased miscarriage rate J:113445
increased susceptibility to otitis media J:113445
polydactyly J:90559, J:113445
respiratory system inflammation J:113445
tympanic membrane perforation J:113445
MecomJbo/Mecom+
involves: BALB/c 		abnormal pinna reflex J:250208
normal hearing/vestibular/ear phenotype J:250208
impaired hearing J:250208
increased susceptibility to otitis media J:250208
middle ear effusion J:250208
middle ear polyps J:250208
MecomJbo/MecomJbo
C3N.C-MecomJbo 		abnormal forebrain morphology J:113445
abnormal limb development J:113445
brachydactyly J:113445
distended pericardium J:113445
embryonic lethality during organogenesis, incomplete penetrance J:113445
perinatal lethality, incomplete penetrance J:113445
polydactyly J:113445
MecomJbo/Mecomtm1Mmor
involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1 		perinatal lethality, complete penetrance J:113445
Mecomtm1.1Miku/Mecom+
B6.Cg-Mecomtm1.1Miku 		abnormal hematopoietic stem cell morphology J:149794
abnormal platelet morphology J:149794
decreased hematopoietic stem cell number J:149794
Mecomtm1.1Miku/Mecom+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal hematopoietic stem cell physiology J:178616
decreased hematopoietic stem cell number J:178616
Mecomtm1.1Miku/Mecomtm1.1Miku
B6.Cg-Mecomtm1.1Miku 		abnormal fetal liver hematopoietic progenitor cell morphology J:149794
abnormal hematopoietic stem cell morphology J:149794
abnormal vitelline vasculature morphology J:149794
decreased hematopoietic stem cell number J:149794
hemorrhage J:149794
lethality throughout fetal growth and development, complete penetrance J:149794
pale yolk sac J:149794
skin edema J:149794
Mecomtm1Aspe/Mecomtm1Aspe
involves: 129S6/SvEvTac * C57BL/6 		abnormal bone collagen fibril morphology J:207915
abnormal bone marrow cell morphology/development J:178429
abnormal common myeloid progenitor cell morphology J:178429
abnormal hematopoietic stem cell physiology J:178429
abnormal intervertebral disk morphology J:207915
abnormal ligament morphology J:207915
abnormal limb posture J:207915
abnormal lumbar vertebrae morphology J:207915
abnormal sacrum morphology J:207915
abnormal spine curvature J:207915
abnormal tail position or orientation J:207915
abnormal tendon collagen fibril morphology J:207915
abnormal vertebral articular process morphology J:207915
abnormal vertebral transverse process morphology J:207915
absent nucleus pulposus J:207915
caudal vertebral fusion J:207915
decreased body size J:178429, J:207915
decreased body weight J:207915
decreased bone mineral density J:207915
decreased bone strength J:207915
decreased bone trabecula number J:207915
decreased hematopoietic stem cell number J:178429
decreased trabecular bone connectivity density J:207915
decreased trabecular bone thickness J:207915
decreased trabecular bone volume J:207915
delayed endochondral bone ossification J:207915
exostosis J:207915
normal hematopoietic system phenotype J:178429
normal homeostasis/metabolism phenotype J:207915
increased bone trabecular spacing J:207915
increased leukocyte cell number J:178429
increased susceptibility to xenobiotic induced morbidity/mortality J:178429
intervertebral disk degeneration J:207915
kyphoscoliosis J:207915
kyphosis J:178429
lordokyphosis J:207915
lordosis J:207915
lumbar vertebral fusion J:207915
malocclusion J:178429
normal neoplasm J:178429
postnatal growth retardation J:178429, J:207915
reduced female fertility J:207915
reduced fertility J:207915
reduced male fertility J:207915
sacral vertebral fusion J:207915
normal skeleton phenotype J:207915
slow postnatal weight gain J:207915
thrombocytopenia J:178429
vertebral fusion J:207915
Mecomtm1Aspe/Mecomtm1Mmor
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		lethality, complete penetrance J:178429
Mecomtm1Aspe/Mecomtm2.1Aspe
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA 		abnormal bone marrow cell morphology/development J:178429
abnormal common myeloid progenitor cell morphology J:178429
decreased common myeloid progenitor cell number J:178429
Mecomtm1Miku/Mecom+
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 * CBA 		decreased hematopoietic stem cell number J:149794
Mecomtm1Miku/Mecomtm1Miku
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal hematopoietic stem cell morphology J:149794
abnormal platelet morphology J:149794
decreased hematopoietic stem cell number J:149794
thrombocytopenia J:149794
Mecomtm1Miku/Mecomtm1Miku
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 * CBA 		decreased hematopoietic stem cell number J:149794
hemorrhage J:149794
lethality throughout fetal growth and development, incomplete penetrance J:149794
skin edema J:149794
Mecomtm1Mmor/Mecomtm1Mmor
involves: 129S2/SvPas * CF-1 		abnormal amnion morphology J:42030
abnormal cranial ganglia morphology J:42030
abnormal diencephalon morphology J:42030
abnormal heart looping J:42030
abnormal liver bud morphology J:42030
abnormal mesonephros morphology J:42030
abnormal myotome development J:42030
abnormal pharyngeal arch morphology J:42030
abnormal spinal nerve morphology J:42030
abnormal superior glossopharyngeal ganglion morphology J:42030
abnormal superior vagus ganglion morphology J:42030
absent hindlimb buds J:42030
absent myotome J:42030
absent paraxial mesoderm J:42030
absent sclerotome J:42030
decreased embryo size J:42030
embryonic lethality during organogenesis, complete penetrance J:42030
enlarged pericardium J:42030
hemorrhage J:42030
incomplete somite formation J:42030
normal nervous system phenotype J:42030
pale placenta J:42030
pale yolk sac J:42030
pharyngeal arch hypoplasia J:42030
small embryonic telencephalon J:42030
small forelimb buds J:42030
small trigeminal ganglion J:42030
trabecula carnea hypoplasia J:42030
Mecomtm2.1Aspe/Mecomtm2.1Aspe
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/SvImJ * C57BL/6 * CBA 		abnormal bone marrow cell morphology/development J:178429
abnormal common myeloid progenitor cell morphology J:178429
decreased common myeloid progenitor cell number J:178429
Mecomtm2.2Aspe/Mecomtm2.2Aspe
involves: 129 * C57BL/6J * FVB/N 		abnormal heart morphology J:213829
abnormal immune system organ morphology J:213829
decreased B cell number J:213829
decreased hematopoietic precursor cell number J:213829
decreased hematopoietic stem cell number J:213829
decreased leukocyte cell number J:213829
double outlet right ventricle J:213829
edema J:213829
hemorrhage J:213829
interrupted aortic arch J:213829
overriding aortic valve J:213829
persistent truncus arteriosus J:213829
postnatal lethality, complete penetrance J:213829
pulmonary vascular congestion J:213829
thrombocytopenia J:213829
ventricular septal defect J:213829
weakness J:213829
weight loss J:213829
Mecomtm2Miku/Mecom+
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		no abnormal phenotype detected J:178616
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory