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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptk2
PTK2 protein tyrosine kinase 2
MGI:95481
99 phenotypes from 13 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Ptk2tm1.1Guan/Ptk2tm1.1Guan
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal myocardial fiber morphology J:105371
abnormal myocardium layer morphology J:105371
cardiac hypertrophy J:105371
cardiac interstitial fibrosis J:105371
dilated heart left ventricle J:105371
disorganized myocardium J:105371
Ptk2tm1.1Guan/Ptk2tm1.1Guan
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal blood vessel morphology J:162690
abnormal placenta vasculature J:162690
abnormal vitelline vasculature morphology J:162690
decreased embryo size J:162690
dilated vasculature J:162690
edema J:162690
embryonic lethality during organogenesis, complete penetrance J:162690
hemorrhage J:162690
increased apoptosis J:162690
increased vascular permeability J:162690
thin placenta labyrinth J:162690
Ptk2tm1.1Guan/Ptk2tm1.2Guan
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J 		abnormal amnion morphology J:99637
abnormal capillary morphology J:99637
abnormal placenta vasculature J:99637
abnormal vascular branching morphogenesis J:99637
abnormal vascular endothelial cell morphology J:99637
abnormal vitelline vasculature morphology J:99637
decreased embryo size J:99637
edema J:99637
embryonic growth retardation J:99637
hemorrhage J:99637
lethality throughout fetal growth and development, incomplete penetrance J:99637
thick dermal layer J:99637
thin placenta labyrinth J:99637
Ptk2tm1.1Itl/Ptk2tm1.1Itl
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal cell physiology J:165360
abnormal fibroblast migration J:165360
abnormal head morphology J:165360
abnormal heart morphology J:165360
abnormal vascular development J:165360
abnormal vitelline vascular remodeling J:165360
abnormal vitelline vasculature morphology J:165360
absent heartbeat J:165360
absent somites J:165360
embryonic lethality during organogenesis, complete penetrance J:165360
enlarged allantois J:165360
failure of chorioallantoic fusion J:165360
hemorrhage J:165360
Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa
B6.129P2-Ptk2tm1.1Jtpa 		increased physiological sensitivity to xenobiotic J:142317
Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa
involves: 129P2/OlaHsd * C57BL/6 		normal muscle phenotype J:142495
Ptk2tm1.2Guan/Ptk2tm1.2Guan
involves: 129P2/OlaHsd * C57BL/6J 		embryonic growth retardation J:99637
embryonic lethality during organogenesis, complete penetrance J:99637
Ptk2tm1Gwm/Ptk2tm1Gwm
Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129P2/OlaHsd * FVB 		decreased incidence of tumors by chemical induction J:94680
decreased keratinocyte migration J:94680
decreased tumor growth/size J:94680
increased keratinocyte apoptosis J:94680
Ptk2tm1Heen/Ptk2tm1Heen
involves: 129/Sv * C57BL/6 		abnormal blood vessel morphology J:157804
abnormal heart development J:157804
abnormal limb development J:157804
abnormal liver development J:157804
abnormal lung development J:157804
abnormal vitelline vasculature morphology J:157804
decreased embryo size J:157804
decreased fibroblast cell migration J:157804
decreased fibroblast proliferation J:157804
decreased survivor rate J:157804
delayed heart development J:157804
delayed hepatic development J:157804
disorganized yolk sac vascular plexus J:157804
edema J:157804
embryonic growth retardation J:157804
embryonic lethality during organogenesis, incomplete penetrance J:157804
hemorrhage J:157804
lethality throughout fetal growth and development, incomplete penetrance J:157804
liver hemorrhage J:157804
normal reproductive system phenotype J:157804
Ptk2tm1Imeg/Ptk2+
CBA.Cg-Ptk2tm1Imeg 		abnormal dorsal aorta morphology J:82150
abnormal vascular development J:82150
decreased embryo size J:82150
Ptk2tm1Imeg/Ptk2tm1Imeg
CBA.Cg-Ptk2tm1Imeg 		abnormal blood vessel morphology J:82150
abnormal vascular endothelial cell development J:82150
absent vitelline blood vessels J:82150
embryonic lethality between somite formation and embryo turning, complete penetrance J:82150
hemorrhage J:82150
Ptk2tm1Imeg/Ptk2tm1Imeg
involves: C57BL/6 * CBA 		abnormal allantois morphology J:29978
abnormal amnion morphology J:29978
abnormal aorta morphology J:29978
abnormal blood circulation J:29978
abnormal blood vessel morphology J:29978
abnormal cell migration J:29273
abnormal cell morphology J:29273
abnormal developmental patterning J:29978
abnormal dorsal aorta morphology J:29273
abnormal ectoderm development J:29273
abnormal embryonic neuroepithelium morphology J:29978
abnormal embryonic tissue morphology J:29978
abnormal endocardium morphology J:29273
abnormal extraembryonic tissue morphology J:29978
abnormal foregut morphology J:29978
abnormal head fold morphology J:29978
abnormal head mesenchyme morphology J:29978
abnormal heart development J:29273, J:29978
abnormal mesocardium morphology J:29273
abnormal mesoderm development J:29273, J:29978
abnormal notochord morphology J:29273, J:29978
abnormal rostral-caudal axis patterning J:29273, J:29978
abnormal somite development J:29273, J:29978
abnormal visceral yolk sac cavity morphology J:29978
abnormal vitelline artery morphology J:29273
decreased embryo size J:29978
embryonic lethality during organogenesis, complete penetrance J:29978
failure of chorioallantoic fusion J:29978
failure of initiation of embryo turning J:29978
hemorrhage J:29978
small amniotic cavity J:29978
small visceral yolk sac J:29978
thick myocardium J:29978
Ptk2tm1Itl/Ptk2+
involves: 129S/SvEv * C57BL/6 		decreased body size J:165360
Ptk2tm1Itl/Ptk2tm1Itl
involves: 129S/SvEv * C57BL/6 		prenatal lethality, complete penetrance J:165360
Ptk2tm1Lfr/Ptk2tm1Ilic
Tg(KRT5-cre)5132Jlj/0
involves: 129X1/SvJ * C57BL/6 * CBA * DBA/2J 		abnormal hair cycle J:107206
abnormal hair follicle orientation J:107206
decreased hair follicle number J:107206
decreased keratinocyte proliferation J:107206
decreased sebaceous gland number J:107206
sparse hair J:107206
thin epidermis J:107206
Ptk2tm1Lfr/Ptk2tm1Lfr
Tg(Tek-cre)1Rwng/0
involves: 129X1/SvJ * FVB/N 		abnormal blood vessel morphology J:104401
abnormal capillary morphology J:104401
abnormal vascular endothelial cell morphology J:104401
abnormal vascular regression J:104401
abnormal vitelline vasculature morphology J:104401
decreased angiogenesis J:104401
decreased embryo size J:104401
disorganized yolk sac vascular plexus J:104401
embryonic lethality during organogenesis, complete penetrance J:104401
hemorrhage J:104401
Ptk2tm1Mmsh/Ptk2tm1Mmsh
Tg(Nes-cre)1Sasa/0
B6.Cg-Ptk2tm1Mmsh Tg(Nes-cre)1Sasa 		abnormal innervation J:132715
abnormal Purkinje cell innervation J:132715
ectopic Bergmann glia cells J:132715
reduced cerebellar foliation J:132715
Ptk2tm2.1Guan/Ptk2tm1.1Guan
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N 		abnormal blood vessel morphology J:162690
dilated vasculature J:162690
increased apoptosis J:162690
increased vascular permeability J:162690
lethality throughout fetal growth and development, complete penetrance J:162690
Ptk2tm2.1Guan/Ptk2tm2.1Guan
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:162690
Ptk2tm3.1Guan/Ptk2tm3.1Guan
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		no abnormal phenotype detected J:195658
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory