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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fas
Fas cell surface death receptor
MGI:95484
190 phenotypes from 11 alleles in 40 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Faslpr/Fastm1Cgn
involves: 129P2/OlaHsd * C57BL/6 * MRL 		enlarged lymph nodes J:114948
enlarged spleen J:114948
Cd19tm1(cre)Cgn/Cd19+
Faslpr/Fastm1Cgn
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL 		enlarged lymph nodes J:114948
enlarged spleen J:114948
increased double-negative T cell number J:114948
Cd19tm1(cre)Cgn/Cd19+
Fastm1Ach/Fastm1Ach
involves: 129P2/OlaHsd * BALB/c 		enlarged spleen J:123556
increased anti-nuclear antigen antibody level J:123556
increased immunoglobulin level J:123556
increased lymphocyte cell number J:123556
Cd19tm1(cre)Cgn/Cd19+
Fastm1Cgn/Fastm1Cgn
B6.Cg-Cd19tm1(cre)Cgn Fastm1Cgn 		increased anti-single stranded DNA antibody level J:114948
Faslpr-cg/Faslpr-cg
CBA/KlJms-Faslpr-cg/J 		abnormal hypersensitivity reaction J:24805, J:81770
abnormal lymph organ size J:24805
abnormal T cell differentiation J:24805
autoimmune response J:24805, J:81770
enlarged lymph nodes J:24805, J:81770
enlarged spleen J:24805
increased anti-nuclear antigen antibody level J:24805
increased autoantibody level J:81770
increased IgG level J:24805, J:81770
increased IgM level J:24805, J:81770
increased immunoglobulin level J:24805
increased spleen weight J:81770
premature death J:24805
Faslpr/Faslpr
AK.MRL-Faslpr 		abnormal renal glomerulus morphology J:7454
enlarged lymph nodes J:7454
expanded mesangial matrix J:7454
glomerulonephritis J:7454
increased anti-double stranded DNA antibody level J:7454
increased anti-nuclear antigen antibody level J:7454
increased autoantibody level J:7454
increased immunoglobulin level J:7454
increased mesangial cell number J:7454
lymph node hemorrhage J:7454
lymph node necrosis J:7454
renal glomerular immunoglobulin deposits J:7454
Faslpr/Faslpr
B6.Cg-Apoetm1Unc Faslpr 		normal cardiovascular system phenotype J:121671
Faslpr/Faslpr
B6.MRL-Faslpr 		abnormal renal glomerulus morphology J:7454
decreased interleukin-2 secretion J:6638
enlarged lymph nodes J:6638, J:7454, J:135036
enlarged spleen J:135036
expanded mesangial matrix J:7454
glomerulonephritis J:7454, J:135036
increased anti-double stranded DNA antibody level J:7454
increased anti-nuclear antigen antibody level J:6638, J:135036
increased autoantibody level J:7454, J:135036
increased double-negative T cell number J:135036
increased immunoglobulin level J:7454
increased mesangial cell number J:7454
lymph node hemorrhage J:7454
lymph node necrosis J:7454
premature death J:6638, J:7454, J:135036
renal glomerular immunoglobulin deposits J:7454, J:135036
Faslpr/Faslpr
B6.MRL-Faslpr/J 		abnormal hepatocyte morphology J:135830
abnormal kidney morphology J:132217
abnormal liver physiology J:120559, J:135830
abnormal NK cell physiology J:115033
abnormal renal glomerulus basement membrane morphology J:132217
abnormal splenic cell ratio J:132217
brain inflammation J:120427
CNS inflammation J:120427
decreased B cell apoptosis J:135830
decreased hepatocyte apoptosis J:135830
demyelination J:120427
enlarged lymph nodes J:119584
focal hepatic necrosis J:135830
increased anti-double stranded DNA antibody level J:132217
increased anti-histone antibody level J:132217
increased anti-nuclear antigen antibody level J:132217
increased anti-single stranded DNA antibody level J:132217
increased autoantibody level J:132217
increased follicular B cell number J:132217
increased immature B cell number J:132217
increased marginal zone B cell number J:132217
increased renal glomerulus apoptosis J:132217
increased splenocyte number J:132217
increased susceptibility to bacterial infection J:136745
increased susceptibility to Picornaviridae infection J:120427
increased transitional stage B cell number J:132217
lymph node hyperplasia J:132217
Faslpr/Faslpr
C3.MRL-Faslpr 		abnormal interleukin level J:8267
abnormal T cell morphology J:8267
abnormal T cell physiology J:8267
abnormal T cell proliferation J:8267
abnormal vagina weight J:114219
decreased apoptosis J:114219
decreased neuron apoptosis J:124252
normal endocrine/exocrine gland phenotype J:1028
lacrimal gland atrophy J:1028
lacrimal gland inflammation J:1028
salivary gland inflammation J:1028
Faslpr/Faslpr
C3.MRL-Faslpr/J 		abnormal airway responsiveness J:106288
abnormal B cell activation J:7454
abnormal renal glomerulus morphology J:7454
abnormal T cell morphology J:7454
decreased eosinophil cell number J:106288
decreased interleukin-2 secretion J:7454
enlarged lymph nodes J:7454
expanded mesangial matrix J:7454
glomerulonephritis J:7454
normal immune system phenotype J:7454
increased anti-double stranded DNA antibody level J:7454
increased anti-nuclear antigen antibody level J:7454
increased apoptosis J:106288
increased autoantibody level J:7454
increased immunoglobulin level J:7454
increased mesangial cell number J:7454
lymph node hemorrhage J:7454
lymph node hyperplasia J:7454
lymph node necrosis J:7454
normal mortality/aging J:120650
premature death J:7454
renal glomerular immunoglobulin deposits J:7454
Faslpr/Faslpr
involves: 129P2/OlaHsd * MRL 		abnormal kidney morphology J:45448
abnormal renal glomerulus morphology J:45448
enlarged lymph nodes J:26250
glomerulonephritis J:45448
increased blood urea nitrogen level J:45448
increased double-negative T cell number J:26250
increased gamma-delta T cell number J:26250
increased urine protein level J:45448
kidney inflammation J:45448
premature death J:26250
Faslpr/Faslpr
involves: C3H * MRL/Mp 		abnormal stria vascularis morphology J:1060, J:34296
abnormal stria vascularis vasculature morphology J:34296
autoimmune response J:1060
increased anti-nuclear antigen antibody level J:34296
increased or absent threshold for auditory brainstem response J:1060, J:34296
increased spleen weight J:34296
increased susceptibility to systemic lupus erythematosus J:34296
increased susceptibility to type III hypersensitivity reaction J:34296
Faslpr/Faslpr
involves: C57BL/6 * MRL/Mp 		enlarged spleen J:73396
increased anti-double stranded DNA antibody level J:73396
increased anti-single stranded DNA antibody level J:73396
increased IgA level J:73396
increased IgG1 level J:73396
increased IgG2a level J:73396
increased IgG2b level J:73396
increased IgG3 level J:73396
increased IgM level J:73396
lymph node hyperplasia J:73396
Faslpr/Faslpr
involves: MRL/Mp 		decreased macrophage apoptosis J:154647
increased susceptibility to bacterial infection J:50903
increased susceptibility to induced morbidity/mortality J:50903
Faslpr/Faslpr
MRL-Faslpr 		abnormal T-helper 2 physiology J:6257
enlarged lymph nodes J:126261
glomerulonephritis J:126261
increased anti-double stranded DNA antibody level J:126261
increased anti-nuclear antigen antibody level J:126261
increased blood urea nitrogen level J:126261
increased IgG level J:126261
increased IgM level J:126261
increased immunoglobulin level J:6257
increased spleen weight J:126261
vascular inflammation J:126261
Faslpr/Faslpr
MRL.Cg-Irf1tm1Mak Faslpr 		abnormal skin condition J:114771
epidermal necrosis J:114771
glomerulonephritis J:114771
increased anti-double stranded DNA antibody level J:114771
increased urine protein level J:114771
kidney failure J:114771
premature death J:114771
renal glomerular immunoglobulin deposits J:114771
skin lesions J:114771
Faslpr/Faslpr
MRL.Cg-Tnfrsf9tm1Byk Faslpr 		premature death J:127197
skin lesions J:127197
Faslpr/Faslpr
MRL/Mp-Agtpbp1atms Faslpr 		enlarged lymph nodes J:103944
enlarged spleen J:103944
enlarged thymus J:103944
increased body weight J:103944
increased tumor incidence J:103944
ruffled hair J:103944
Faslpr/Faslpr
MRL/Mp-Faslpr 		abnormal B cell morphology J:108760
abnormal B cell receptor editing J:131138
abnormal cardiovascular system physiology J:27634
abnormal circulating protein level J:27634
abnormal coronary artery morphology J:27634
abnormal cytotoxic T cell physiology J:7488
abnormal gland morphology J:18512
abnormal glomerular capillary endothelium morphology J:28885
abnormal glomerular capillary morphology J:28885
abnormal immune system organ morphology J:28885
abnormal immune system physiology J:28885
abnormal interleukin level J:8267
abnormal lymph node cell ratio J:6257
abnormal lymph node morphology J:27634
abnormal marginal zone B cell morphology J:131138
abnormal submandibular gland morphology J:18512
abnormal T cell morphology J:8267, J:108760
abnormal T cell physiology J:8267
abnormal T cell proliferation J:8267
abnormal T-helper 2 physiology J:6257
abnormal thymus medulla morphology J:28885
abnormal thyroid follicle morphology J:28171
abnormal thyroid gland morphology J:28171
abnormal type III hypersensitivity reaction J:28885
blood vessel inflammation J:28885
decreased interleukin-2 secretion J:6638, J:7488
normal endocrine/exocrine gland phenotype J:18512
enlarged lymph nodes J:13757, J:27634, J:28885, J:108760
enlarged Peyer's patches J:28885
enlarged spleen J:28885
enlarged thymus J:13757
glomerular crescent J:28885
glomerulonephritis J:13757, J:27634, J:28885
increased anti-double stranded DNA antibody level J:6257, J:27634, J:131138
increased anti-erythrocyte antigen antibody level J:27634
increased anti-nuclear antigen antibody level J:27634, J:28885
increased anti-single stranded DNA antibody level J:27634
increased autoantibody level J:28885
increased circulating serum albumin level J:28885
increased circulating total protein level J:28885
increased IgA level J:28885
increased IgG1 level J:13757, J:28885
increased IgG2a level J:13757, J:28885
increased IgG2b level J:28885
increased IgG level J:27634
increased IgM level J:28885
increased immunoglobulin level J:6257, J:13757, J:28885
increased kidney cell proliferation J:27634
increased mesangial cell number J:28885
increased renal glomerulus basement membrane thickness J:28885
increased susceptibility to autoimmune disorder J:108760
increased thymus weight J:28885
increased urine protein level J:28885
joint swelling J:27634
lacrimal gland inflammation J:18512
lymph node hemorrhage J:27634
lymph node hyperplasia J:27634
lymph node necrosis J:27634
premature death J:13757, J:27634, J:28885
renal cast J:28885
renal glomerular immunoglobulin deposits J:13757, J:27634
renal glomerular protein deposits J:27634
salivary gland inflammation J:18512
skin lesions J:28885
submandibular gland inflammation J:21965
thymus atrophy J:27634
thymus cortex atrophy J:13757, J:28885
thyroid gland inflammation J:28171
Faslpr/Faslpr
MRL/MpJ-Faslpr 		abnormal leukocyte adhesion J:126009
abnormal leukocyte morphology J:126009
autoimmune response J:125114
blood vessel inflammation J:137066
decreased activated T cell number J:137066
decreased B cell number J:137066
decreased CD4-positive, alpha-beta T cell number J:137066
decreased CD8-positive, alpha-beta T cell number J:137066
enlarged lymph nodes J:137066
enlarged spleen J:137066
glomerulonephritis J:125114, J:132514, J:137066
impaired leukocyte tethering or rolling J:126009
increased anti-nuclear antigen antibody level J:137066
increased autoantibody level J:137066
increased double-negative T cell number J:137066
increased immunoglobulin level J:125114
premature death J:125114, J:137066
renal glomerular immunoglobulin deposits J:125114
Faslpr/Faslpr
MRL/MpJ-Faslpr/J 		abnormal conjunctival epithelium morphology J:123192
abnormal enzyme/coenzyme activity J:109815
abnormal immunoglobulin level J:122315
abnormal kidney physiology J:127199
abnormal myocardium layer morphology J:14151
abnormal renal glomerulus morphology J:7454, J:127199
abnormal spatial learning J:14151
abnormal stria vascularis morphology J:3638
abnormal strial intermediate cell morphology J:3638
albuminuria J:122315
CNS inflammation J:14151
conjunctivitis J:123192
cortical renal glomerulopathies J:122315
decreased IgG level J:122315
decreased immature B cell number J:122315
decreased marginal zone B cell number J:122315
decreased mature B cell number J:122315
decreased spleen germinal center number J:122315
decreased transitional stage B cell number J:122315
dilated renal glomerular capsule J:122315
enlarged lymph nodes J:7454, J:92084
expanded mesangial matrix J:127199
glomerular crescent J:122315
glomerulonephritis J:7454, J:92084, J:122315, J:127199
impaired coordination J:14151
increased anti-double stranded DNA antibody level J:7454, J:92084, J:122315
increased anti-nuclear antigen antibody level J:7454, J:14151, J:92084, J:111811
increased autoantibody level J:14151, J:92084
increased IgG level J:92084
increased immunoglobulin level J:7454, J:122315
increased mesangial cell number J:127199
increased neutrophil cell number J:127199
increased or absent threshold for auditory brainstem response J:3638
increased plasma cell number J:122315
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084, J:122315
lymph node hemorrhage J:7454
lymph node necrosis J:7454
podocyte foot process effacement J:127199
premature death J:7454
renal glomerulus hypertrophy J:122315
salivary gland inflammation J:92084
vascular inflammation J:127199
normal vision/eye phenotype J:123192
Faslpr/Faslpr
NOD.MRL(B6)-Faslpr 		decreased susceptibility to autoimmune diabetes J:64051
Faslpr/Faslpr
NOD.MRL-Faslpr 		decreased susceptibility to autoimmune diabetes J:78679
Faslpr/Fastm1.1Cgn
involves: C57BL/6 * MRL 		abnormal immune system morphology J:114948
enlarged lymph nodes J:114948
enlarged spleen J:114948
Faslpr/Fastm1Cgn
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 * MRL 		enlarged lymph nodes J:114948
enlarged spleen J:114948
increased double-negative T cell number J:114948
Fasm1Btlr/Fasm1Btlr
C57BL/6J-Fasm1Btlr 		decreased CD4-positive, alpha-beta T cell number J:216052
decreased CD8-positive, alpha-beta T cell number J:216052
increased neutrophil cell number J:216052
increased NK cell number J:216052
Fasm2Btlr/Fasm2Btlr
C57BL/6J-Fasm2Btlr 		increased central memory CD4-positive, alpha-beta T cell number J:271891
increased effector memory CD4-positive, alpha-beta T cell number J:271891
Fastheo/Fastheo
either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu) 		enlarged lymph nodes J:104190
increased anti-nuclear antigen antibody level J:104190
Fastm1.1(ALPP)Chnd/Fastm1.1(ALPP)Chnd
involves: C57BL/6 * SJL 		no abnormal phenotype detected J:101977
Fastm1.1Cgn/Fastm1.1Cgn
involves: C57BL/6 		abnormal immune system morphology J:114948
enlarged lymph nodes J:114948
enlarged spleen J:114948
Fastm1Ach/Fastm1Ach
Tg(GZMB-cre)1Jcb/?
involves: C57BL/6 * FVB/N 		increased anti-nuclear antigen antibody level J:123556
increased double-positive T cell number J:123556
Fastm1Ach/Fastm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/?
Not Specified 		abnormal liver morphology J:123556
abnormal spleen morphology J:123556
abnormal spleen periarteriolar lymphoid sheath morphology J:123556
decreased apoptosis J:123556
enlarged spleen J:123556
increased anti-nuclear antigen antibody level J:123556
increased dendritic cell number J:123556
increased IgG level J:123556
increased IgM level J:123556
increased immunoglobulin level J:123556
Fastm1Ach/Fastm1Ach
Tg(Lck-cre)548Jxm/?
involves: C57BL/6 * CBA 		increased anti-nuclear antigen antibody level J:123556
increased double-positive T cell number J:123556
Fastm1Cgn/Fastm1Cgn
C57BL/6-Fastm1Cgn 		normal immune system phenotype J:114948
Fastm1Cgn/Fastm1Cgn
Cd19tm1(cre)Cgn/Cd19+
Tg(Cd4-cre)1Cwi/0
B6.Cg-Tg(Cd4-cre)1Cwi Cd19tm1(cre)Cgn Fastm1Cgn 		increased anti-single stranded DNA antibody level J:114948
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
involves: C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:114741
normal immune system phenotype J:114741
Fastm1Cgn/Fastm1Cgn
Tg(Cd4-cre)1Cwi/0
B6.Cg-Tg(Cd4-cre)1Cwi Fastm1Cgn 		abnormal immune system cell morphology J:114948
abnormal immune system organ morphology J:114948
abnormal thymus involution J:114948
alveolitis J:114948
decreased B cell number J:114948
decreased T cell number J:114948
enlarged spleen J:114948
increased activated T cell number J:114948
increased anti-single stranded DNA antibody level J:114948
increased double-negative T cell number J:114948
increased inflammatory response J:114948
increased memory T cell number J:114948
increased T cell apoptosis J:114948
kidney inflammation J:114948
liver inflammation J:114948
lung inflammation J:114948
lymph node hypoplasia J:114948
premature death J:114948
pulmonary fibrosis J:114948
spleen hypoplasia J:114948
weight loss J:114948
Fastm1Cgn/Fastm1Cgn
Tg(Lck-cre)I57Jxm/0
B6.Cg-Fastm1Cgn Tg(Lck-cre)I57Jxm 		lymph node hypoplasia J:114948
Fastm1Cgn/Fastm1Cgn
Tg(Mx1-cre)1Cgn/0
B6.Cg-Fastm1Cgn Tg(Mx1-cre)1Cgn 		abnormal immune system morphology J:114948
enlarged lymph nodes J:114948
enlarged spleen J:114948
Fastm1Dlo/Fastm1Dlo
involves: 129P2/OlaHsd * C57BL/6 		abnormal apoptosis J:90750
abnormal thymus involution J:90750
enlarged lymph nodes J:31847
enlarged spleen J:31847
increased immunoglobulin level J:31847
Fastm1Osa/Fastm1Osa
involves: 129P2/OlaHsd * C57BL/6 		abnormal hepatocyte morphology J:64296
abnormal hypersensitivity reaction J:32125, J:64296
abnormal lymph organ size J:64296
abnormal T cell clonal deletion J:32125
enlarged lymph nodes J:32125, J:64296
enlarged spleen J:32125, J:64296
increased anti-double stranded DNA antibody level J:32125
increased anti-single stranded DNA antibody level J:32125
increased autoantibody level J:32125
increased B cell number J:32125
increased IgG1 level J:32125
increased IgG2a level J:32125
increased IgG2b level J:32125
increased IgG3 level J:32125
increased IgG level J:32125
increased leukocyte cell number J:32125
increased lymphocyte cell number J:32125, J:64296
increased susceptibility to parasitic infection J:81397
liver hyperplasia J:64296
lymphoid hyperplasia J:64296
premature death J:64296
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12/10/2024
MGI 6.24 		The Jackson Laboratory