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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fasn
fatty acid synthase
MGI:95485
29 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fasntm1.1Sem/Fasntm1.1Sem
involves: 129X1/SvJ * FVB/N 		prenatal lethality, complete penetrance J:127793
Fasntm1Schi/Fasn+
129S7/SvEvBrd-Fasntm1Schi 		prenatal lethality, incomplete penetrance J:83624
Fasntm1Schi/Fasn+
involves: 129S7/SvEvBrd * C57BL/6J 		prenatal lethality, incomplete penetrance J:83624
Fasntm1Schi/Fasntm1Schi
129S7/SvEvBrd-Fasntm1Schi 		embryonic lethality before implantation J:83624
Fasntm1Schi/Fasntm1Schi
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality before implantation, complete penetrance J:83624
Fasntm1Sem/Fasntm1Sem
Speer6-ps1Tg(Alb-cre)21Mgn/?
involves: 129X1/SvJ * C57BL/6 * DBA 		abnormal blood homeostasis J:127793
decreased circulating cholesterol level J:127793
decreased circulating glucose level J:127793
decreased circulating insulin level J:127793
decreased liver cholesterol level J:127793
decreased saturated fatty acids level J:127793
decreased total body fat amount J:127793
decreased total fat pad weight J:127793
hepatic steatosis J:127793
increased circulating free fatty acids level J:127793
increased circulating glucagon level J:127793
increased liver weight J:127793
increased triglyceride level J:127793
Fasntm1Sem/Fasntm1Sem
Tg(Ins2-cre)25Mgn/?
involves: 129X1/SvJ * C57BL/6 * DBA 		abnormal eating behavior J:127482
abnormal fatty acids level J:127482
abnormal hypothalamus physiology J:127482
abnormal pancreatic beta cell physiology J:127482
decreased body weight J:127482
decreased circulating free fatty acids level J:127482
decreased compensatory feeding amount J:127482
decreased total body fat amount J:127482
increased circulating glucose level J:127482
increased circulating insulin level J:127482
increased circulating triglyceride level J:127482
increased locomotor activity J:127482
increased oxygen consumption J:127482
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory