Fcgr2b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fcgr2b
Fc receptor, IgG, low affinity IIb
MGI:95499

50 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv B6.Cg-Fcgr2b^tm1Ttk Fcgr3^tm1Jsv Fcer1a^tm1Knt Fcgr1^tm1Jsv Fcer2a^tm1Max	abnormal macrophage physiology	J:144620
	abnormal mast cell physiology	J:144620
	increased susceptibility to type I hypersensitivity reaction	J:144620
Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6	impaired macrophage phagocytosis	J:83995
Fcgr2b^tm1.2Jsv/Fcgr2b⁺ X/Yaa involves: C57BL/6 * FVB/N * SB/Le	abnormal kidney morphology	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased monocyte cell number	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	premature death	J:179175
Fcgr2b^tm1.2Jsv/Fcgr2b^tm1.2Jsv Sle16^C57BL/6/Sle16^C57BL/6 involves: C57BL/6 * FVB/N	abnormal adaptive immunity	J:179175
	abnormal glomerular capillary thrombosis	J:179175
	abnormal renal glomerulus morphology	J:179175
	albuminuria	J:179175
	normal immune system phenotype	J:179175
	increased immunoglobulin level	J:179175
	increased susceptibility to induced arthritis	J:179175
	kidney inflammation	J:179175
Fcgr2b^tm1Ttk/Fcgr2b⁺ X/Yaa involves: 129S4/SvJae * C57BL/6 * SB/Le	increased monocyte cell number	J:129409
Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6 involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N	abnormal kidney morphology	J:179175
	albuminuria	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased anti-histone antibody level	J:179175
	increased anti-single stranded DNA antibody level	J:179175
	increased spleen weight	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	premature death	J:179175
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Il17a^tm1Yiw/Il17a⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased survivor rate	J:191090
	glomerulonephritis	J:191090
	increased plasma cell number	J:191090
	increased spleen germinal center number	J:191090
	kidney inflammation	J:191090
	premature death	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Il17a^tm1Yiw/Il17a^tm1Yiw involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased survivor rate	J:191090
	decreased susceptibility to systemic lupus erythematosus	J:191090
	increased anti-double stranded DNA antibody level	J:191090
	increased anti-nuclear antigen antibody level	J:191090
	increased double-negative T cell number	J:191090
	increased plasma cell number	J:191090
	increased spleen germinal center number	J:191090
	premature death	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Pdcd1^tm1Hon/Pdcd1^tm1Hon involves: 129S2/SvPas * 129S4/SvJae * BALB/c	abnormal cytokine level	J:207275
	abnormal urinary bladder urothelium morphology	J:207275
	abnormal urine cytokine level	J:207275
	decreased body weight	J:207275
	increased autoantibody level	J:207275
	oliguria	J:207275
	urinary bladder inflammation	J:207275
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Sle21^129P2/Ola/Sle21^129P2/Ola B6.129S4-Fcgr2b^tm1Ttk	abnormal adaptive immunity	J:179175
	abnormal glomerular capillary thrombosis	J:179175
	abnormal renal glomerulus morphology	J:179175
	albuminuria	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased anti-histone antibody level	J:179175
	increased anti-single stranded DNA antibody level	J:179175
	increased autoantibody level	J:179175
	increased IgG2a level	J:179175
	increased immunoglobulin level	J:179175
	increased spleen weight	J:179175
	increased susceptibility to induced arthritis	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	kidney inflammation	J:179175
	premature death	J:179175
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tg(Ins2-TFRC/OVA)296Wehi/0 involves: 129S4/SvJae * C57BL/6	increased susceptibility to autoimmune diabetes	J:122114
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa	abnormal kidney morphology	J:127600
	abnormal splenocyte physiology	J:127600
	autoimmune response	J:127600
	enlarged spleen	J:127600
	increased anti-nuclear antigen antibody level	J:127600
	increased susceptibility to systemic lupus erythematosus	J:127600
	premature death	J:127600
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm1Sbn/Traf3ip2⁺ involves: 129 * 129S4/SvJae * C57BL/6	abnormal neutrophil morphology	J:191090
	abnormal T cell morphology	J:191090
	decreased survivor rate	J:191090
	increased anti-double stranded DNA antibody level	J:191090
	increased anti-nuclear antigen antibody level	J:191090
	increased autoantibody level	J:191090
	increased double-negative T cell number	J:191090
	increased IgG level	J:191090
	increased memory T cell number	J:191090
	increased monocyte cell number	J:191090
	increased myeloid dendritic cell number	J:191090
	increased neutrophil cell number	J:191090
	increased plasma cell number	J:191090
	increased plasmacytoid dendritic cell number	J:191090
	increased single-positive T cell number	J:191090
	increased spleen germinal center number	J:191090
	increased susceptibility to systemic lupus erythematosus	J:191090
	kidney inflammation	J:191090
	premature death	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn involves: 129 * 129S4/SvJae * C57BL/6	abnormal T cell morphology	J:191090
	decreased survivor rate	J:191090
	decreased susceptibility to systemic lupus erythematosus	J:191090
	increased anti-double stranded DNA antibody level	J:191090
	increased anti-nuclear antigen antibody level	J:191090
	increased autoantibody level	J:191090
	increased double-negative T cell number	J:191090
	increased IgG level	J:191090
	premature death	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm2Sbn/Traf3ip2⁺ involves: 129S4/SvJae * BALB/c * C57BL/6	enlarged spleen	J:191090
	increased germinal center B cell number	J:191090
	increased plasma cell number	J:191090
	increased spleen weight	J:191090
	spleen hyperplasia	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm2Sbn/Traf3ip2^tm2Sbn Cd79a^tm1(cre)Reth/Cd79a⁺ involves: 129S4/SvJae * BALB/c * C57BL/6	glomerulonephritis	J:191090
	increased germinal center B cell number	J:191090
	increased plasma cell number	J:191090
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk X/Yaa B6.Cg-Fcgr2b^tm1Ttk Yaa	abnormal kidney morphology	J:127600
	autoimmune response	J:127600
	enlarged spleen	J:127600
	increased anti-nuclear antigen antibody level	J:127600
	increased susceptibility to systemic lupus erythematosus	J:127600
	premature death	J:127600

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