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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgfr1
fibroblast growth factor receptor 1
MGI:95522
264 phenotypes from 36 alleles in 39 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm2(cre)Wrst/En1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
involves: 129S1/Sv * 129X1/SvJ 		abnormal cerebellum morphology J:83004
abnormal gait J:83004
abnormal locus ceruleus morphology J:83004
abnormal midbrain morphology J:83004
abnormal posture J:83004
abnormal trochlear nerve morphology J:83004
absent cerebellum vermis J:83004
absent inferior colliculus J:83004
impaired coordination J:83004
Fgfr1Eask/Fgfr1+
BALB/cByJ-Fgfr1Eask/GrsrJ 		abnormal ear position J:179274
abnormal ear shape J:179274
abnormal outer ear morphology J:179274
increased or absent threshold for auditory brainstem response J:179274
lowered ear position J:179274
normal vision/eye phenotype J:179274
Fgfr1Eask/Fgfr1Eask
BALB/cByJ-Fgfr1Eask/GrsrJ 		prenatal lethality, complete penetrance J:179274
Fgfr1Hspy/Fgfr1+
(C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1 		abnormal outer ear morphology J:171915
abnormal stapes morphology J:171915
normal hearing/vestibular/ear phenotype J:171915
Fgfr1Hspy/Fgfr1+
C3HeB/FeJ-Fgfr1Hspy 		abnormal incus morphology J:171915
abnormal outer ear morphology J:171915
abnormal snout morphology J:171915
abnormal stapes morphology J:171915
normal hearing/vestibular/ear phenotype J:171915
short snout J:171915
small ears J:171915
Fgfr1Hspy/Fgfr1+
C3HeB/FeJ-Hspy 		abnormal auditory bulla morphology J:95895
abnormal cochlear nerve compound action potential J:95895
abnormal ear physiology J:95895
abnormal ear shape J:95895
abnormal incudostapedial joint morphology J:95895
abnormal incus body morphology J:95895
abnormal incus long process morphology J:95895
abnormal incus morphology J:95895
abnormal incus short process morphology J:95895
abnormal inner ear morphology J:95895
abnormal middle ear morphology J:95895
abnormal outer ear morphology J:95895
abnormal pinna reflex J:95895
abnormal stapes morphology J:95895
abnormal stapes posterior crus morphology J:95895
absent incus lenticular process J:95895
absent round window J:95895
absent stapes head J:95895
decreased cochlear outer hair cell number J:95895
decreased endocochlear potential J:95895
decreased round window size J:95895
excessive cerumen J:95895
increased susceptibility to otitis media J:95895
lowered ear position J:95895
short mandible J:95895
short nasal bone J:95895
small cranium J:95895
small ears J:95895
Fgfr1Hspy/Fgfr1Hspy
C3HeB/FeJ-Fgfr1Hspy 		abnormal embryonic-extraembryonic boundary morphology J:171915
embryonic growth retardation J:171915
embryonic lethality between somite formation and embryo turning, complete penetrance J:171915
Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd 		increased respiratory quotient J:211773
Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd 		abnormal embryo size J:211773
embryonic growth retardation J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR 		abnormal gastrulation J:83004
embryonic lethality, complete penetrance J:83004
Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
involves: ICR 		abnormal brain morphology J:78879
abnormal craniofacial morphology J:78879
abnormal developmental patterning J:78879
abnormal embryonic growth/weight/body size J:78879
abnormal embryonic tissue morphology J:78879
abnormal extraembryonic tissue morphology J:78879
abnormal heart development J:78879
abnormal neural tube morphology J:78879
embryonic lethality, complete penetrance J:78879
Fgfr1tm1Cxd/Fgfr1tm1Cxd
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal axial skeleton morphology J:54222
abnormal developmental patterning J:54222
abnormal embryonic tissue morphology J:54222
abnormal neural tube morphology J:54222
embryonic lethality, complete penetrance J:54222
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR 		abnormal craniofacial bone morphology J:81179
cleft palate J:81179
normal craniofacial phenotype J:81179
Fgfr1tm1Jpa/Fgfr1tm1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal cerebellum development J:83004
abnormal cerebellum vermis morphology J:83004
absent inferior colliculus J:83004
neonatal lethality J:83004
Fgfr1tm1Jpa/Fgfr1tm1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR 		abnormal hyoid bone lesser horn morphology J:81179
cleft palate J:81179
normal craniofacial phenotype J:81179
Fgfr1tm1Jpa/Fgfr1tm1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal medial nasal prominence morphology J:298139
abnormal palatal mesenchymal cell proliferation J:298139
abnormal palatal rugae morphology J:298139
abnormal secondary palate development J:298139
abnormal tongue position J:298139
abnormal tooth development J:298139
cleft primary palate J:298139
cleft secondary palate J:298139
cleft upper lip J:298139
complete cleft palate J:298139
decreased palatal shelf size J:298139
failure of palatal shelf elevation J:298139
micrognathia J:298139
palatal shelves fail to meet at midline J:298139
persistence of medial edge epithelium during palatal shelf fusion J:298139
Fgfr1tm1Jrt/Fgfr1tm1Jrt
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal chorion morphology J:22117
abnormal egg cylinder morphology J:22117
abnormal extraembryonic tissue morphology J:22117
abnormal gastrulation movements J:22117
abnormal head fold morphology J:22117
abnormal head mesenchyme morphology J:22117
abnormal heart tube morphology J:22117
abnormal mesoderm development J:22117
abnormal midbrain morphology J:22117
abnormal neural fold morphology J:22117
abnormal neural plate morphology J:22117
abnormal notochordal process morphology J:22117
abnormal posterior primitive streak morphology J:22117
abnormal primitive streak morphology J:22117
abnormal rostral-caudal body axis extension J:22117
abnormal visceral yolk sac endoderm morphology J:22117
abnormal visceral yolk sac mesenchyme morphology J:22117
abnormal visceral yolk sac morphology J:22117
absent somites J:22117
absent visceral yolk sac blood islands J:22117
decreased embryo size J:22117
decreased paraxial mesoderm size J:22117
embryonic growth retardation J:22117
embryonic lethality between implantation and somite formation, incomplete penetrance J:22117
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:22117
embryonic lethality during organogenesis, incomplete penetrance J:22117
enlarged allantois J:22117
excessive folding of visceral yolk sac J:22117
failure of primitive streak formation J:22117
increased axial mesoderm size J:22117
kinked neural tube J:22117
Fgfr1tm1Jrt/Fgfr1tm2Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal carpal bone morphology J:49154
abnormal craniofacial bone morphology J:49154
abnormal digit morphology J:49154
abnormal limb morphology J:49154
abnormal sternocostal joint morphology J:49154
abnormal tarsal bone morphology J:49154
caudal body truncation J:49154
cervical vertebral transformation J:49154
decreased caudal vertebrae number J:49154
lumbar vertebral transformation J:49154
neonatal lethality, complete penetrance J:49154
oligodactyly J:49154
prenatal lethality, incomplete penetrance J:49154
rib fusion J:49154
sacral vertebral transformation J:49154
short tibia J:49154
syndactyly J:49154
vertebral transformation J:49154
Fgfr1tm1Jrt/Fgfr1tm4Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal tail development J:49154
prenatal lethality, complete penetrance J:49154
Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal vertebrae morphology J:49154
cervical vertebral transformation J:49154
lumbar vertebral transformation J:49154
rib fusion J:49154
sacral vertebral transformation J:49154
thoracic vertebral transformation J:49154
Fgfr1tm1Led/Fgfr1tm1Led
involves: 129S4/SvJae * NIH Black Swiss 		abnormal developmental patterning J:22118
abnormal egg cylinder morphology J:22118
abnormal extraembryonic tissue morphology J:22118
abnormal mesoderm development J:22118
abnormal neural tube morphology J:22118
abnormal primitive streak morphology J:22118
abnormal rostral-caudal axis patterning J:22118
abnormal rostral-caudal body axis extension J:22118
absent limb buds J:22118
absent somites J:22118
decreased embryo size J:22118
embryonic growth retardation J:22118
embryonic lethality between implantation and somite formation, incomplete penetrance J:22118
embryonic lethality during organogenesis, complete penetrance J:22118
excessive folding of visceral yolk sac J:22118
small proamniotic cavity J:22118
small visceral yolk sac J:22118
Fgfr1tm1Swnr/Fgfr1tm1Swnr
involves: 129S7/SvEvBrd * C57BL/6 		normal integument phenotype J:101854
Fgfr1tm1Upir/Fgfr1tm1.1Upir
involves: C57BL/6J 		abnormal fetal cardiomyocyte proliferation J:95803
abnormal heart development J:95803
abnormal myocardial fiber morphology J:95803
dilated heart left ventricle J:95803
dilated heart right ventricle J:95803
heart hypoplasia J:95803
increased heart atrium size J:95803
thin myocardium J:95803
Fgfr1tm1Upir/Fgfr1tm1.1Upir
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * ICR 		abnormal cochlea morphology J:78879
abnormal cochlear hair cell development J:78879
abnormal cochlear sensory epithelium morphology J:78879
abnormal organ of Corti morphology J:78879
abnormal orientation of inner hair cell stereociliary bundles J:78879
absent cochlear outer hair cells J:78879
absent organ of Corti supporting cells J:78879
decreased cochlear hair cell number J:78879
increased cochlear inner hair cell number J:78879
neonatal lethality, complete penetrance J:78879
Fgfr1tm1Upir/Fgfr1tm1Upir
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * ICR 		abnormal cochlear sensory epithelium morphology J:78879
abnormal organ of Corti morphology J:78879
neonatal lethality, complete penetrance J:78879
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(GFAP-cre)25Mes/0
involves: FVB/N 		abnormal astrocyte morphology J:110263
abnormal brain commissure morphology J:110263
abnormal corpus callosum morphology J:110263
abnormal hippocampal commissure morphology J:110263
abnormal neuronal migration J:110263
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(KRT5-cre)5132Jlj/0
involves: C57BL/6 * C57BL/6J * DBA/2J 		no abnormal phenotype detected J:158802
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(Mnx1-GFP)1Slp/?
Tg(Nes-cre)1Kln/?
Not Specified 		abnormal axon guidance J:122940
abnormal motor neuron morphology J:122940
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal corpus callosum morphology J:110263
abnormal dorsal telencephalic commissure morphology J:110263
abnormal frontal lobe morphology J:110263
Fgfr1tm2.1Cxd/Fgfr1+
B6J.129S6(Cg)-Fgfr1tm2.1Cxd 		abnormal maxillary-premaxillary suture morphology J:228708
abnormal palatine bone morphology J:228708
abnormal viscerocranium morphology J:228708
Fgfr1tm2.1Cxd/Fgfr1+
D2.129S6(Cg)-Fgfr1tm2.1Cxd 		abnormal basisphenoid bone morphology J:228708
abnormal maxillary-premaxillary suture morphology J:228708
abnormal palatine bone morphology J:228708
abnormal viscerocranium morphology J:228708
midface hypoplasia J:228708
premature maxillary-premaxillary suture closure J:228708
Fgfr1tm2.1Cxd/Fgfr1+
involves: 129S6/SvEvTac * FVB/N 		abnormal craniofacial bone morphology J:63959
facial asymmetry J:63959
increased osteoblast cell number J:63959
increased osteoblast proliferation J:63959
long incisors J:63959
midface hypoplasia J:63959
ocular hypertelorism J:63959
premature coronal suture closure J:63959
premature cranial suture closure J:63959
premature metopic suture closure J:63959
premature sagittal suture closure J:63959
Fgfr1tm2.1Cxd/Fgfr1tm2.1Cxd
involves: 129S6/SvEvTac * FVB/N 		abnormal craniofacial bone morphology J:63959
craniofacial asymmetry J:63959
decreased body size J:63959
ocular hypertelorism J:63959
premature cranial suture closure J:63959
short tail J:63959
Fgfr1tm2.1Jrt/Fgfr1tm2.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:49154
Fgfr1tm2Jrt/Fgfr1tm2Jrt
involves: 129S1/Sv * 129X1/SvJ 		abnormal cerebellum vermis morphology J:83004
decreased inferior colliculus size J:83004
Fgfr1tm2Jrt/Fgfr1tm2Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal carpal bone morphology J:49154
abnormal cervical axis morphology J:49154
abnormal craniofacial bone morphology J:49154
abnormal digit morphology J:49154
abnormal limb morphology J:49154
abnormal phalanx morphology J:49154
abnormal rostral-caudal axis patterning J:49154
abnormal sternocostal joint morphology J:49154
abnormal tail development J:49154
abnormal tarsal bone morphology J:49154
caudal body truncation J:49154
cervical vertebral transformation J:49154
decreased caudal vertebrae number J:49154
increased rib number J:49154
lumbar vertebral transformation J:49154
neonatal lethality, complete penetrance J:49154
oligodactyly J:49154
rib fusion J:49154
sacral vertebral transformation J:49154
small second pharyngeal arch J:49154
syndactyly J:49154
thoracic vertebral transformation J:49154
vertebral transformation J:49154
Fgfr1tm2Jrt/Fgfr1tm2Jrt
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal alisphenoid bone morphology J:81179
abnormal cochlear sensory epithelium morphology J:78879
abnormal hyoid bone lesser horn morphology J:81179
abnormal incus morphology J:81179
abnormal malleus morphology J:81179
abnormal middle ear ossicle morphology J:81179
abnormal neural crest cell migration J:81179
abnormal neural crest cell morphology J:81179
abnormal organ of Corti morphology J:78879
abnormal pterygoid bone morphology J:81179
abnormal retrotympanic process morphology J:81179
abnormal second pharyngeal arch morphology J:81179
abnormal secondary palate development J:81179
abnormal styloid process morphology J:81179
abnormal tongue position J:81179
absent gonial bone J:81179
absent middle ear ossicles J:81179
absent tympanic ring J:81179
cleft palate J:81179
decreased cochlear outer hair cell number J:78879
decreased tympanic ring size J:81179
failure of palatal shelf elevation J:81179
neonatal lethality, complete penetrance J:78879, J:81179
small ears J:81179
small gonial bone J:81179
Fgfr1tm2Jrt/Fgfr1tm2Jrt
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR 		abnormal alisphenoid bone morphology J:81179
abnormal incus morphology J:81179
abnormal malleus morphology J:81179
abnormal middle ear ossicle morphology J:81179
abnormal pterygoid bone morphology J:81179
abnormal second pharyngeal arch morphology J:81179
abnormal temporal bone squamous part morphology J:81179
normal craniofacial phenotype J:81179
decreased tympanic ring size J:81179
small gonial bone J:81179
Fgfr1tm3.1Cxd/Fgfr1tm3.1Cxd
involves: 129S6/SvEvTac * Black Swiss 		embryonic lethality, complete penetrance J:75137
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal embryonic autopod plate morphology J:101736
oligodactyly J:101736
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal apical ectodermal ridge morphology J:101736
abnormal axial skeleton morphology J:101736
abnormal cartilage development J:101736
abnormal forelimb bud morphology J:101736
abnormal forelimb stylopod morphology J:101736
abnormal forelimb zeugopod morphology J:101736
abnormal hindlimb morphology J:101736
abnormal neural plate morphology J:101736
abnormal somite size J:101736
forelimb oligodactyly J:101736
neonatal lethality, complete penetrance J:101736
Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal gastrulation J:49154
abnormal somite development J:49154
absent somites J:49154
decreased paraxial mesoderm size J:49154
embryonic lethality during organogenesis, incomplete penetrance J:49154
Fgfr1tm3.1Sor/Fgfr1tm3.1Sor
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal neural tube closure J:105920
embryonic growth retardation J:105920
lethality throughout fetal growth and development, complete penetrance J:105920
spina bifida J:105920
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal embryonic autopod plate morphology J:101736
oligodactyly J:101736
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal apical ectodermal ridge morphology J:101736
abnormal axial skeleton morphology J:101736
abnormal cartilage development J:101736
abnormal forelimb bud morphology J:101736
abnormal forelimb stylopod morphology J:101736
abnormal forelimb zeugopod morphology J:101736
abnormal hindlimb morphology J:101736
abnormal neural plate morphology J:101736
abnormal somite size J:101736
forelimb oligodactyly J:101736
neonatal lethality, complete penetrance J:101736
Fgfr1tm3Cxd/Fgfr1tm3Cxd
involves: 129S6/SvEvTac * Black Swiss 		embryonic lethality between implantation and somite formation, complete penetrance J:75137
Fgfr1tm3Jrt/Fgfr1tm3Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal gastrulation J:49154
abnormal somite development J:49154
absent somites J:49154
decreased paraxial mesoderm size J:49154
embryonic lethality during organogenesis, incomplete penetrance J:49154
Fgfr1tm3Sor/Fgfr1tm3Sor
involves: 129S4/SvJaeSor * C57BL/6J 		embryonic lethality, complete penetrance J:105920
Fgfr1tm4.1Jrt/Fgfr1tm4.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:49154
Fgfr1tm4.1Jrt/Fgfr1tm4.1Jrt
involves: 129S1/Sv * 129X1/SvJ * ICR 		normal hearing/vestibular/ear phenotype J:78879
Fgfr1tm4.1Sor/Fgfr1tm4.1Sor
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal digit morphology J:105920
decreased embryo size J:105920
lethality throughout fetal growth and development, incomplete penetrance J:105920
Fgfr1tm4Jrt/Fgfr1tm4Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal carpal bone morphology J:49154
abnormal cartilage development J:49154
abnormal cervical axis morphology J:49154
abnormal craniofacial bone morphology J:49154
abnormal forelimb morphology J:49154
abnormal limb morphology J:49154
abnormal phalanx morphology J:49154
abnormal rostral-caudal axis patterning J:49154
abnormal sternocostal joint morphology J:49154
abnormal tail morphology J:49154
abnormal tarsal bone morphology J:49154
cervical vertebral transformation J:49154
decreased caudal vertebrae number J:49154
embryonic lethality during organogenesis, incomplete penetrance J:49154
lethality throughout fetal growth and development, incomplete penetrance J:49154
lumbar vertebral transformation J:49154
neonatal lethality, complete penetrance J:49154
sacral vertebral transformation J:49154
small second pharyngeal arch J:49154
vertebral transformation J:49154
Fgfr1tm4Sor/Fgfr1tm4Sor
involves: 129S4/SvJaeSor * C57BL/6J 		embryonic lethality, complete penetrance J:105920
Fgfr1tm5.1Jrt/Fgfr1tm5.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:49154
Fgfr1tm5.1Sor/Fgfr1tm5.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
129S4.Cg-Fgfr1tm5.1Sor H2az2Tg(Wnt1-cre)11Rth 		midline facial cleft J:226497
Fgfr1tm5.1Sor/Fgfr1tm9.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm9.1Sor H2az2Tg(Wnt1-cre)11Rth 		cleft palate J:226497
Fgfr1tm5.1Sor/Fgfr1tm10.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm10.1Sor H2az2Tg(Wnt1-cre)11Rth 		cleft palate J:226497
Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
129S4/SvJaeSor-Fgfr1tm5.2Sor 		abnormal blastocyst morphology J:226497
abnormal developmental patterning J:226497
abnormal embryonic epiblast morphology J:226497
abnormal primitive endoderm morphology J:226497
embryonic lethality, complete penetrance J:226497
Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal developmental patterning J:105920
abnormal gastrulation movements J:105920
abnormal mesoderm development J:105920
caudal body truncation J:105920
craniorachischisis J:105920
decreased paraxial mesoderm size J:105920
embryonic growth retardation J:105920
embryonic lethality during organogenesis, complete penetrance J:105920
enlarged heart J:105920
failure of heart looping J:105920
failure of somite differentiation J:105920
increased axial mesoderm size J:105920
Fgfr1tm5Jrt/Fgfr1tm5Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal craniofacial bone morphology J:49154
abnormal lateral plate mesoderm morphology J:49154
abnormal limb morphology J:49154
abnormal neural fold morphology J:49154
abnormal somite development J:49154
abnormal sternocostal joint morphology J:49154
abnormal tail morphology J:49154
broad limb buds J:49154
caudal body truncation J:49154
cervical vertebral transformation J:49154
decreased caudal vertebrae number J:49154
fusion of atlas and occipital bones J:49154
neonatal lethality J:49154
prenatal lethality, incomplete penetrance J:49154
rib fusion J:49154
small second pharyngeal arch J:49154
thoracic vertebral transformation J:49154
Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal sternocostal joint morphology J:49154
abnormal vertebrae morphology J:49154
cervical vertebral transformation J:49154
lumbar vertebral transformation J:49154
rib fusion J:49154
sacral vertebral transformation J:49154
thoracic vertebral transformation J:49154
Fgfr1tm6Jrt/Fgfr1tm6Jrt
involves: 129S1/Sv * 129X1/SvJ 		abnormal cerebellum vermis morphology J:83004
decreased inferior colliculus size J:83004
Fgfr1tm6Jrt/Fgfr1tm6Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal axial skeleton morphology J:49154
abnormal craniofacial bone morphology J:49154
abnormal lateral plate mesoderm morphology J:49154
abnormal limb morphology J:49154
abnormal neural fold formation J:49154
abnormal somite development J:49154
abnormal sternocostal joint morphology J:49154
broad limb buds J:49154
caudal body truncation J:49154
cervical vertebral transformation J:49154
decreased caudal vertebrae number J:49154
decreased somite size J:49154
embryonic lethality during organogenesis, incomplete penetrance J:49154
fusion of atlas and occipital bones J:49154
neonatal lethality, complete penetrance J:49154
perinatal lethality, incomplete penetrance J:49154
rib fusion J:49154
small second pharyngeal arch J:49154
thoracic vertebral transformation J:49154
vertebral transformation J:49154
Fgfr1tm6Jrt/Fgfr1tm6Jrt
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal cochlear hair cell development J:78879
abnormal cochlear hair cell morphology J:78879
abnormal cochlear sensory epithelium morphology J:78879
abnormal orientation of inner hair cell stereociliary bundles J:78879
absent cochlear outer hair cells J:78879
absent organ of Corti supporting cells J:78879
increased cochlear inner hair cell number J:78879
neonatal lethality, complete penetrance J:78879
Fgfr1tm7.1Sor/Fgfr1tm7.1Sor
129S4/SvJaeSor-Fgfr1tm7.1Sor 		normal no abnormal phenotype detected J:226497
Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
129S4/SvJaeSor-Fgfr1tm8.1Sor 		abnormal axial skeleton morphology J:226497
abnormal rib morphology J:226497
abnormal thoracic cage morphology J:226497
abnormal thoracic vertebrae morphology J:226497
decreased lumbar vertebrae number J:226497
decreased thoracic vertebrae number J:226497
normal growth/size/body region phenotype J:226497
normal homeostasis/metabolism phenotype J:226497
rib bifurcation J:226497
Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
129S4/SvJaeSor-Fgfr1tm9.1Sor 		cleft palate J:226497
increased thoracic vertebrae number J:226497
incus hypoplasia J:226497
lumbar vertebral transformation J:226497
malleus hypoplasia J:226497
middle ear ossicle hypoplasia J:226497
postaxial polydactyly J:226497
postnatal lethality, complete penetrance J:226497
second pharyngeal arch hypoplasia J:226497
stapes hypoplasia J:226497
styloid process hypoplasia J:226497
tympanic ring hypoplasia J:226497
Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
129S4/SvJaeSor-Fgfr1tm10.1Sor 		abnormal embryo development J:226497
abnormal neural crest cell migration J:226497
abnormal somite development J:226497
absent second pharyngeal arch J:226497
bleb J:226497
caudal body truncation J:226497
decreased somite size J:226497
embryonic growth arrest J:226497
embryonic growth retardation J:226497
embryonic lethality, complete penetrance J:226497
Tg(Gnrh1-Fgfr1)1Tsai/Tg(Gnrh1-Fgfr1)1Tsai
involves: C57BL/6J * DBA/2J 		abnormal hypothalamus secretion J:95057
abnormal neuron morphology J:95057
decreased litter size J:95057
decreased neuron number J:95057
decreased testis weight J:95057
delayed vaginal opening J:95057
early reproductive senescence J:95057
normal homeostasis/metabolism phenotype J:95057
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory