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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgfr1
fibroblast growth factor receptor 1
MGI:95522
81 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Chd7Whi/Chd7+
Fgfr1Hspy/Fgfr1+
C3HeB/FeJ-Chd7Whi Fgfr1Hspy 		abnormal heart morphology J:161880
choanal atresia J:161880
cleft palate J:161880
normal nervous system phenotype J:161880
perinatal lethality, complete penetrance J:161880
preweaning lethality, complete penetrance J:161880
normal reproductive system phenotype J:161880
Cpa3tm3(icre)Hrr/Cpa3+
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J 		absent mast cells J:221184
acanthosis J:221184
decreased body weight J:221184
female infertility J:221184
impaired skin barrier function J:221184
increased keratinocyte proliferation J:221184
progressive hair loss J:221184
reduced male fertility J:221184
skin inflammation J:221184
Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		supernumerary teeth J:119280
Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster 		abnormal limb development J:149478
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal small intestine morphology J:139005
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N 		abnormal kidney development J:95018
abnormal ureteric bud morphology J:95018
decreased renal glomerulus number J:95018
hydronephrosis J:95018
impaired branching involved in ureteric bud morphogenesis J:95018
small kidney J:95018
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal renal/urinary system phenotype J:107078
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal small intestine morphology J:139005
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal digestive system physiology J:139005
abnormal small intestine crypts of Lieberkuhn morphology J:139005
abnormal small intestine morphology J:139005
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal renal/urinary system phenotype J:107078
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N 		normal renal/urinary system phenotype J:95018
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		normal cardiovascular system phenotype J:143444
facial cleft J:143444
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal urethra urothelium morphology J:223057
normal reproductive system phenotype J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N 		abnormal ureteric bud morphology J:95018
decreased renal glomerulus number J:95018
hydronephrosis J:95018
small kidney J:95018
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Msx2-rtTA)888Lma/0
Tg(tetO-cre)1Jaw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal reproductive system physiology J:223057
genital tubercle hypoplasia J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal ureteric bud elongation J:107078
abnormal ureteric bud morphology J:107078
absent kidney J:107078
absent metanephric mesenchyme J:107078
decreased kidney cell proliferation J:107078
ectopic ureteric bud J:107078
impaired branching involved in ureteric bud morphogenesis J:107078
increased kidney apoptosis J:107078
increased metanephric mesenchyme apoptosis J:107078
small ureteric bud J:107078
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Twist2tm1.1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal reproductive system physiology J:223057
genital tubercle hypoplasia J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm3.1Lni/Fgfr2tm3.1Lni
Tg(Pax3-cre)1Joe/0
involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL 		abnormal metanephric mesenchyme morphology J:167305
abnormal ureteric bud invasion J:167305
absent kidney J:167305
ectopic ureteric bud J:167305
impaired branching involved in ureteric bud morphogenesis J:167305
increased metanephric mesenchyme apoptosis J:167305
small ureteric bud J:167305
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J 		decreased maxillary shelf size J:298139
small frontonasal prominence J:298139
Fgfr1tm1Swnr/Fgfr1tm1Swnr
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J 		abnormal skin adnexa morphology J:158802
acanthosis J:158802
decreased body size J:158802
progressive hair loss J:158802
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(GFAP-cre)25Mes/0
involves: 129X1/SvJ * FVB/N 		abnormal astrocyte morphology J:110263
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J 		abnormal chemokine level J:221184
abnormal epidermal layer morphology J:158802
abnormal epidermis stratum granulosum morphology J:158802
abnormal hair cycle J:158802
abnormal hair follicle morphology J:158802
abnormal mast cell morphology J:221184
abnormal skin adnexa morphology J:158802
abnormal skin appearance J:158802
absent hair follicles J:158802
absent sebaceous gland J:158802
acanthosis J:158802, J:221184
alopecia J:158802
decreased body size J:158802
decreased body weight J:221184
dermatitis J:221184
dry skin J:158802
female infertility J:158802, J:221184
impaired skin barrier function J:158802, J:221184
increased IgE level J:158802
increased IgG1 level J:158802
increased IgG2a level J:158802
increased keratinocyte proliferation J:158802, J:221184
increased mast cell number J:221184
polydipsia J:158802
progressive hair loss J:158802, J:221184
reduced male fertility J:158802, J:221184
skin fibrosis J:158802
skin inflammation J:158802, J:221184
small hair follicles J:158802
thick epidermis J:221184
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal vascular development J:143444
normal cardiovascular system phenotype J:143444
normal mortality/aging J:143444
Fgfr1tm5.1Sor/Fgfr1tm10.1Sor
Stat3tm2Aki/Stat3tm2Aki
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor 		normal craniofacial phenotype J:226497
Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		normal cellular phenotype J:242687
normal nervous system phenotype J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm6.1Jrt/Fgfr1tm1Jpa
involves: 129 		normal nervous system phenotype J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		absent telencephalon J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
involves: 129 		absent telencephalon J:242687
normal cellular phenotype J:242687
increased cell death J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
involves: 129 		frontonasal prominence hypoplasia J:242687
microphthalmia J:242687
telencephalon hypoplasia J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
involves: 129 		abnormal lateral ganglionic eminence morphology J:242687
abnormal medial ganglionic eminence morphology J:242687
frontonasal prominence hypoplasia J:242687
microphthalmia J:242687
telencephalon hypoplasia J:242687
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory