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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccn2
cellular communication network factor 2
MGI:95537
73 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccn2tm1.1(folA/cre)Hze/Ccn2+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr 		no abnormal phenotype detected J:227758
Ccn2tm1.1Alea/Ccn2tm1.1Alea
Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal skin physiology J:171300
decreased physiological sensitivity to xenobiotic J:171300
Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J 		abnormal trabecular bone morphology J:163027
decreased bone mineral density J:163027
Ccn2tm1Kml/Ccn2tm1Kml
involves: 129X1/SvJ * BALB/cJ 		abnormal appendicular skeleton morphology J:83260
abnormal axial skeleton morphology J:83260
abnormal cartilage development J:83260
abnormal cartilage morphology J:83260
abnormal cervical atlas morphology J:83260
abnormal chondrocyte physiology J:83260
abnormal long bone hypertrophic chondrocyte zone J:83260
abnormal long bone morphology J:83260
abnormal lung development J:130165
abnormal Meckel's cartilage morphology J:83260
abnormal nasal cartilage morphology J:83260
abnormal pulmonary alveolus morphology J:130165
abnormal respiratory conducting tube morphology J:130165
abnormal rib morphology J:83260
abnormal sternebra morphology J:83260
abnormal thoracic cage morphology J:83260
abnormal type II pneumocyte morphology J:130165
abnormal vertebrae morphology J:83260
abnormal vertebral column morphology J:83260
absent ethmoid bone J:83260
bowed fibula J:83260
bowed radius J:83260
bowed tibia J:83260
bowed ulna J:83260
normal cardiovascular system phenotype J:83260
chondrodystrophy J:83260
cleft secondary palate J:83260
decreased angiogenesis J:83260
decreased bone mineral density of femur J:83260
decreased lung weight J:130165
decreased mesenchymal cell proliferation involved in lung development J:130165
decreased trabecular bone thickness J:83260
delayed endochondral bone ossification J:83260
disorganized long bone epiphyseal plate J:83260
domed cranium J:83260
failure of palatal shelf elevation J:83260
increased long bone epiphyseal plate size J:83260
increased width of hypertrophic chondrocyte zone J:83260
neonatal lethality, complete penetrance J:83260
pectus excavatum J:83260
pulmonary hypoplasia J:130165
respiratory failure J:83260
short mandible J:83260
short sternum J:83260
small alveolar lamellar bodies J:130165
small lung J:130165
small lung saccule J:130165
small thoracic cavity J:83260
Ccn2tm1Mae/Ccn2tm1Mae
129S6/SvEvTac-Ccn2tm1Mae 		neonatal lethality, complete penetrance J:165111
Ccn2tm1Mae/Ccn2tm2Mae
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:165111
Ccn2tm1Mga/Ccn2+
involves: 129S6/SvEvTac * C57BL/6NTac 		abnormal trabecular bone morphology J:163027
decreased bone mineral density J:163027
Ccn2tm1Mga/Ccn2tm1.1Vlcg
Tg(BGLAP-cre)1Clem/0
involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ 		abnormal trabecular bone morphology J:163027
decreased bone mineral density J:163027
Ccn2tm1Mga/Ccn2tm1Mga
involves: 129S6/SvEvTac * C57BL/6NTac 		abnormal angiogenesis J:145696
abnormal bone ossification J:145696
abnormal sternum morphology J:145696
abnormal vertebrae morphology J:145696
chondrodystrophy J:145696
neonatal lethality, complete penetrance J:145696
respiratory failure J:145696
Ccn2tm2Mae/Ccn2+
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S6/SvEvTac 		abnormal bone structure J:165111
abnormal facial morphology J:165111
abnormal pharyngeal arch development J:165111
abnormal vasculogenesis J:165111
decreased bone mineral content J:165111
decreased lean body mass J:165111
embryonic growth retardation J:165111
embryonic lethality during organogenesis, complete penetrance J:165111
kinked tail J:165111
short tail J:165111
small ears J:165111
Ccn2tm2Mae/Ccn2+
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal bone structure J:165111
abnormal eye development J:165111
abnormal vasculogenesis J:165111
decreased bone mineral content J:165111
decreased embryo size J:165111
decreased lean body mass J:165111
embryonic growth retardation J:165111
embryonic lethality during organogenesis, complete penetrance J:165111
facial cleft J:165111
kinked tail J:165111
lateral facial cleft J:165111
midline facial cleft J:165111
short face J:165111
short tail J:165111
small ears J:165111
Ccn2tm2Mae/Ccn2+
Tg(CAG-cre/Esr1*)5Amc/?
involves: 129S6/SvEvTac * C57BL/6 * CBA 		no abnormal phenotype detected J:165111
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory