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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fli1
Friend leukemia integration 1
MGI:95554
58 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Fli1tm1.1Dkw/Fli1+
B6.129S6-Fli1tm1.1Dkw
decreased B cell number J:137876
Fli1tm1.1Dkw/Fli1tm1.1Dkw
B6.129S6-Fli1tm1.1Dkw
abnormal B cell differentiation J:137876
abnormal class switch recombination J:137876
abnormal humoral immune response J:137876
abnormal splenic cell ratio J:137876
decreased B cell number J:137876
decreased B cell proliferation J:137876
decreased follicular B cell number J:137876
decreased IgG1 level J:137876
decreased IgG3 level J:137876
increased marginal zone B cell number J:137876
increased transitional stage B cell number J:137876
spleen hyperplasia J:137876
Fli1tm1Adh/Fli1tm1Adh
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
abnormal brain meninges morphology J:64178
abnormal megakaryocyte morphology J:64178
abnormal megakaryocyte progenitor cell morphology J:64178
abnormal vascular development J:64178
embryonic lethality during organogenesis, complete penetrance J:64178
intracranial hemorrhage J:64178
Fli1tm1Ber/Fli1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
increased leukemia incidence J:33052
Fli1tm1Ber/Fli1tm1Ber
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)
decreased thymocyte number J:33052
Fli1tm1Ber/Fli1tm1Ber
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
anemia J:33052
decreased hematocrit J:33052
enlarged spleen J:33052
increased leukemia incidence J:33052
Fli1tm1Dkw/Fli1tm1Dkw
either: B6.Cg-Fli1tm1Dkw or (involves: CD-1) or (involves: 129S6/SvEvTac * C57BL/6)
abnormal proerythroblast morphology J:74166
decreased embryo size J:63242
decreased megakaryocyte cell number J:74166
embryonic lethality during organogenesis, complete penetrance J:63242
impaired hematopoiesis J:63242
intraventricular hemorrhage J:63242
pale liver J:63242
pale yolk sac J:63242
small liver J:63242
spinal hemorrhage J:63242
Fli1tm1Matr/Fli1tm1Matr
Tg(Tek-cre)12Flv/0
B6.Cg-Fli1tm1Matr Tg(Tek-cre)12Flv
abnormal arteriole morphology J:158658
abnormal blood vessel morphology J:158658
abnormal pericyte morphology J:158658
abnormal vascular smooth muscle morphology J:158658
abnormal venule morphology J:158658
aneurysm J:158658
decreased body weight J:158658
dilated capillary J:158658
hemorrhage J:158658
increased vascular endothelial cell number J:158658
increased vascular permeability J:158658
vascular stenosis J:158658
Fli1tm1Matr/Fli1tm1Matr
Tg(Tek-cre)12Flv/Tg(Tek-cre)12Flv
B6.Cg-Fli1tm1Matr Tg(Tek-cre)12Flv
perinatal lethality, incomplete penetrance J:158658
prenatal lethality, complete penetrance J:158658
Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA * DBA
abnormal megakaryocyte differentiation J:167426
normal hematopoietic system phenotype J:167426
thrombocytopenia J:167426
Fli1tm1Morl/Fli1tm1Morl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA
abnormal erythropoiesis J:167426
abnormal leukocyte morphology J:167426
abnormal megakaryocyte differentiation J:167426
abnormal thrombopoiesis J:167426
decreased granulocyte number J:167426
normal hematopoietic system phenotype J:167426
increased erythrocyte cell number J:167426
increased erythroid progenitor cell number J:167426
increased monocyte cell number J:167426
increased NK cell number J:167426
thrombocytopenia J:167426
Fli1tm2Adh/Fli1tm2Adh
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
intracranial hemorrhage J:64178
Tg(Fli1)1Ber/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
increased thymocyte number J:33052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory