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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Flna
filamin, alpha
MGI:95556
46 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
FlnaDilp2/Y
involves: BALB/cAnN * C3H/HeN 		prenatal lethality, complete penetrance J:75964
FlnaDilp2/Flna+
involves: BALB/cAnN * C3H/HeN 		abnormal eye morphology J:75964
mydriasis J:75964
FlnaDilp2/Y
involves: BALB/cAnN * C3H/HeN * C57BL/6 		abnormal cardiac outflow tract development J:112274
abnormal sternum morphology J:112274
cleft secondary palate J:112274
decreased heart right ventricle size J:112274
double outlet right ventricle J:112274
edema J:112274
failure of palatal shelf elevation J:112274
lethality throughout fetal growth and development, complete penetrance J:112274
omphalocele J:112274
ostium primum atrial septal defect J:112274
persistent truncus arteriosus J:112274
thick mitral valve J:112274
ventricular septal defect J:112274
FlnaDilp2/Flna+
involves: BALB/cAnN * C3H/HeN * C57BL/6 		abnormal palatal shelf fusion at midline J:112274
abnormal sternum morphology J:112274
abnormal xiphoid process morphology J:112274
double outlet right ventricle J:112274
irregularly shaped pupil J:112274
ventricular septal defect J:112274
FlnaDilp2/FlnaDilp2
involves: BALB/cAnN * C3H/HeN 		prenatal lethality, complete penetrance J:75964
FlnaGt(F015B06)Wrst/Y
chimera involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:160967
Flnatm1.1Caw/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal atrioventricular cushion morphology J:118252
abnormal blood vessel morphology J:118252
abnormal brain size J:118252
abnormal cardiac outflow tract development J:118252
abnormal vascular endothelial cell morphology J:118252
abnormal vascular endothelial cell physiology J:118252
normal behavior/neurological phenotype J:118252
cyanosis J:118252
interrupted aortic arch J:118252
neonatal lethality, complete penetrance J:118252
persistent truncus arteriosus J:118252
Flnatm1.2Caw/Y
involves: 129S4/SvJae * C57BL/6 		abnormal angiogenesis J:118252
abnormal blood vessel morphology J:118252
abnormal cardiac outflow tract development J:118252
abnormal intersomitic vessel morphology J:118252
abnormal vascular regression J:118252
atrial septal defect J:118252
common ventricle J:118252
edema J:118252
hemorrhage J:118252
interrupted aortic arch J:118252
lethality throughout fetal growth and development, incomplete penetrance J:118252
persistent truncus arteriosus J:118252
ventricular septal defect J:118252
Flnatm1.2Caw/Flna+
involves: 129S4/SvJae * C57BL/6 		abnormal heart morphology J:118252
abnormal thrombosis J:118252
dilated heart J:118252
edema J:118252
emphysema J:118252
hepatic necrosis J:118252
increased leukocyte cell number J:118252
postnatal lethality, incomplete penetrance J:118252
premature death J:118252
preweaning lethality, incomplete penetrance J:118252
reduced female fertility J:118252
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory