Flt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Flt1
FMS-like tyrosine kinase 1
MGI:95558

31 phenotypes from 9 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Flt1^tm1.1Fong/Flt1^tm1.1Fong Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6NCr * CD-1	decreased body size	J:202202
	decreased myocardial infarct size	J:202202
	increased angiogenesis	J:202202
	increased endothelial cell proliferation	J:202202
	increased macrophage cell number	J:202202
	increased vascular permeability	J:202202
Flt1^tm1.1Vlcg/Flt1^tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Flt1^tm1Eze/Flt1^tm1Eze Tg(Prrx1-cre)1Cjt/0 involves: C57BL/6J * SJL/J	normal cardiovascular system phenotype	J:147285
Flt1^tm1Gne/Flt1^tm1Gne Not Specified	cornea vascularization	J:114973
Flt1^tm1Jrt/Flt1⁺ involves: CD-1	increased response of heart to induced stress	J:101949
Flt1^tm1Jrt/Flt1⁺ Not Specified	abnormal blood circulation	J:164891
	abnormal blood vessel morphology	J:164891
	abnormal physiological neovascularization	J:151369
	increased angiogenesis	J:164891
Flt1^tm1Jrt/Flt1^tm1.2Fong involves: 129 * C57BL/6NCr * CD-1	abnormal blood vessel morphology	J:202202
Flt1^tm1Jrt/Flt1^tm1Jrt either: (involves: 129/Sv) or (involves: CD-1) or (involves: ICR)	abnormal embryo development	J:54830
	abnormal embryonic erythrocyte morphology	J:54830
	increased hemangioblast number	J:54830
Flt1^tm1Jrt/Flt1^tm1Jrt involves: 129S1/Sv * 129X1/SvJ	abnormal dorsal aorta morphology	J:26845
	abnormal heart development	J:26845
	abnormal vascular development	J:26845
	abnormal visceral yolk sac blood island morphology	J:26845
	abnormal vitelline vasculature morphology	J:26845
	disorganized yolk sac vascular plexus	J:26845
	embryonic growth arrest	J:26845
	embryonic lethality during organogenesis, complete penetrance	J:26845
Flt1^tm1Msh/Flt1^tm1Msh involves: 129S4/SvJae * C57BL/6J	normal cardiovascular system phenotype	J:49507
	cornea vascularization	J:114973
	impaired macrophage chemotaxis	J:49507
	normal reproductive system phenotype	J:49507
Flt1^tm1Msh/Flt1^tm1Msh involves: 129S4/SvJaeSor * C57BL/6 * FVB	abnormal sensory capabilities/reflexes/nociception	J:172783
	neuron degeneration	J:172783
Flt1^tm2Msh/Flt1⁺ involves: 129S/SvEv * C57BL/6J	abnormal embryo development	J:95387
Flt1^tm2Msh/Flt1^tm2Msh B6.129S-Flt1^tm2Msh	no abnormal phenotype detected	J:95387
Flt1^tm2Msh/Flt1^tm2Msh involves: 129S/SvEv * C57BL/6J	abnormal dorsal aorta morphology	J:95387
	abnormal embryo turning	J:95387
	abnormal vascular development	J:95387
	abnormal vascular endothelial cell morphology	J:95387
	embryonic growth arrest	J:95387
	embryonic lethality during organogenesis, incomplete penetrance	J:95387
Gt(ROSA)26Sor^{tm1(Flt1,EGFP)Dlam}/Gt(ROSA)26Sor⁺ Tg(Thy1-cre)1Dlam/0 involves: 129 * C57BL/6 * FVB	abnormal sensory capabilities/reflexes/nociception	J:172783

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24