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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Flt3
FMS-like tyrosine kinase 3
MGI:95559
79 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Flt3em1(IMPC)Ccpcz/Flt3em1(IMPC)Ccpcz
C57BL/6NCrl-Flt3em1(IMPC)Ccpcz/Ccpcz 		abnormal digit morphology J:211773
abnormal eye morphology J:211773
abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal skeletal muscle morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal uterus morphology J:211773
decreased effector memory T-helper cell number J:211773
decreased lean body mass J:211773
decreased NK cell number J:211773
enlarged heart J:211773
hydrometra J:211773
Flt3m1Btlr/Flt3m1Btlr
C57BL/6J-Flt3m1Btlr 		abnormal dendritic cell antigen presentation J:159599
abnormal dendritic cell physiology J:159599
abnormal macrophage physiology J:105543
abnormal NK cell physiology J:159599
decreased body weight J:159599
decreased circulating interferon-alpha level J:159599
decreased circulating interferon-gamma level J:159599
decreased circulating interleukin-12 level J:159599
decreased dendritic cell number J:159599
decreased interferon-alpha secretion J:159599
decreased interferon-gamma secretion J:159599
decreased interleukin-12 secretion J:159599
decreased NK cell number J:159599
decreased plasmacytoid dendritic cell number J:159599
decreased splenocyte number J:159599
increased circulating interleukin-6 level J:159599
increased circulating tumor necrosis factor level J:159599
increased susceptibility to Herpesvirales infection J:105543
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:159599
increased susceptibility to Riboviria infection J:105543
small lymph nodes J:159599
Flt3tm1.1Dosm/Flt3+
B6.129(C)-Flt3tm1.1Dosm 		abnormal bone marrow cell number J:205200
abnormal bone marrow cell physiology J:205200
abnormal bone marrow morphology J:205200
abnormal definitive hematopoiesis J:205200
abnormal spleen morphology J:205200
arrested B cell differentiation J:205200
decreased bone marrow cell number J:205200
enlarged spleen J:205200
increased bone marrow cell number J:205200
increased spleen white pulp amount J:205200
premature death J:205200
Flt3tm1Dgg/Flt3+
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		abnormal hematopoietic system morphology/development J:126003
Flt3tm1Dgg/Flt3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell differentiation J:126003
abnormal definitive hematopoiesis J:126003
decreased B cell number J:126003
decreased mature B cell number J:126003
decreased T cell number J:126003
enlarged spleen J:126003
increased granulocyte number J:126003
increased leukocyte cell number J:126003
increased monocyte cell number J:126003
increased spleen red pulp amount J:126003
increased spleen white pulp amount J:126003
Flt3tm1Dgg/Flt3tm1Dgg
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		abnormal hematopoietic system morphology/development J:126003
Flt3tm1Dgg/Flt3tm1Dgg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell differentiation J:126003
abnormal common myeloid progenitor cell morphology J:126003
abnormal definitive hematopoiesis J:126003
decreased B cell number J:126003
decreased mature B cell number J:126003
decreased T cell number J:126003
enlarged spleen J:126003
increased granulocyte number J:126003
increased leukocyte cell number J:126003
increased monocyte cell number J:126003
increased spleen red pulp amount J:126003
increased spleen white pulp amount J:126003
Flt3tm1Dosm/Flt3+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn 		abnormal bone marrow cell morphology/development J:133528
abnormal definitive hematopoiesis J:133528
abnormal spleen white pulp morphology J:133528
arrested B cell differentiation J:133528
decreased B cell number J:133528
decreased erythrocyte cell number J:133528
decreased hemoglobin content J:133528
decreased leukocyte cell number J:133528
decreased lymphocyte cell number J:133528
decreased megakaryocyte cell number J:133528
decreased neutrophil cell number J:133528
decreased pre-B cell number J:133528
delayed cellular replicative senescence J:133528
enlarged spleen J:133528
extramedullary hematopoiesis J:133528
increased bone marrow cell number J:133528
increased dendritic cell number J:133528
increased granulocyte number J:133528
increased hematopoietic stem cell number J:133528
increased leukocyte cell number J:133528
increased monocyte cell number J:133528
increased neutrophil cell number J:133528
increased pro-B cell number J:133528
intermingled spleen red and white pulp J:133528
premature death J:133528
Flt3tm1Irl/Flt3tm1Irl
either: 129S/SvEv-Flt3tm1Irl or (involves: 129S/SvEv * C57BL/6J) 		abnormal B cell differentiation J:27238, J:99149
decreased pre-B cell number J:27238
decreased pro-B cell number J:27238
Flt3tm2.1Dosm/Flt3+
B6.129(C)-Flt3tm2.1Dosm 		abnormal B cell morphology J:205200
abnormal bone marrow cell physiology J:205200
abnormal bone marrow morphology J:205200
abnormal definitive hematopoiesis J:205200
abnormal myelopoiesis J:205200
abnormal spleen morphology J:205200
enlarged spleen J:205200
extramedullary hematopoiesis J:205200
increased B cell derived lymphoma incidence J:205200
increased bone marrow cell number J:205200
increased hemangiosarcoma incidence J:205200
increased histiocytic sarcoma incidence J:205200
increased leukocyte cell number J:205200
increased megakaryocyte cell number J:205200
increased pre-pro B cell number J:205200
increased pro-B cell number J:205200
increased spleen white pulp amount J:205200
intermingled spleen red and white pulp J:205200
myeloid hyperplasia J:205200
premature death J:205200
thrombocytosis J:205200
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory