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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Flt3l
FMS-like tyrosine kinase 3 ligand
MGI:95560
34 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Flt3ltm1Imx/Flt3ltm1Imx
C57BL/6-Flt3ltm1Imx 		abnormal common lymphocyte progenitor cell morphology J:79569
abnormal common myeloid progenitor cell morphology J:62536
abnormal dendritic cell morphology J:62536, J:89868
abnormal immature B cell morphology J:62536
abnormal immune system cell morphology J:62536
abnormal immune system organ morphology J:62536
abnormal leukocyte morphology J:62536
decreased B cell number J:79569
decreased bone marrow cell number J:62536
decreased double-negative T cell number J:79569
decreased hematopoietic stem cell number J:62536
decreased leukocyte cell number J:62536
decreased lymphocyte cell number J:62536
decreased myeloid dendritic cell number J:62536, J:89868
decreased NK cell number J:62536
decreased plasmacytoid dendritic cell number J:62536, J:89868
decreased pre-B cell number J:79569
decreased pro-B cell number J:62536, J:79569
impaired myelopoiesis J:62536
increased IgM level J:62536
increased length of allograft survival J:89868
increased neutrophil cell number J:62536
lymph node hypoplasia J:62536
spleen hypoplasia J:62536
Flt3ltm1Imx/Flt3ltm1Imx
involves: C57BL/6 		abnormal dendritic cell antigen presentation J:223508
abnormal dendritic cell chemotaxis J:223508
abnormal memory T cell physiology J:189122
abnormal T-helper 1 physiology J:189122
decreased CD11b-high dendritic cell number J:223508
decreased CD103-positive CD11b-low dendritic cell number J:223508
decreased dendritic cell number J:189122
decreased macrophage cell number J:189122
decreased monocyte cell number J:189122
decreased NK cell number J:189122
decreased plasmacytoid dendritic cell number J:189122
increased neutrophil cell number J:189122
increased susceptibility to parasitic infection J:189122
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory