Fn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fn1
fibronectin 1
MGI:95566

72 phenotypes from 12 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fn1^Gt(Ex180)Byg/Fn1^Gt(Ex180)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal gastrulation	J:70273
	embryonic lethality, complete penetrance	J:70273
Fn1^tm1.1Sakai/Fn1^tm1.1Sakai Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal liver physiology	J:214945
	abnormal response to injury	J:214945
Fn1^tm1Bwg/Fn1^tm1Bwg involves: 129S4/SvJae * BALB/c * C57BL/6J	normal cardiovascular system phenotype	J:93027
	normal neoplasm	J:93027
Fn1^tm1Bwg/Fn1^tm1Bwg involves: 129S4/SvJae * C57BL/6	normal immune system phenotype	J:90917
Fn1^tm1Bwg/Fn1^tm1Bwg involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:90917
Fn1^tm1Feb/Fn1^tm1Feb involves: 129X1/SvJ	abnormal protein level	J:84274
	normal homeostasis/metabolism phenotype	J:84274
	premature death	J:84274
	normal reproductive system phenotype	J:84274
Fn1^tm1Hyn/Fn1^tm1Hyn involves: 129S2/SvPas * C57BL/6J	abnormal amnion morphology	J:16247
	abnormal developmental patterning	J:16247
	abnormal dorsal aorta morphology	J:16247
	abnormal embryonic neuroepithelium morphology	J:16247
	abnormal embryonic tissue morphology	J:16247
	abnormal endocardium morphology	J:16247
	abnormal extraembryonic tissue morphology	J:16247
	abnormal heart development	J:16247
	abnormal lateral plate mesoderm morphology	J:16247
	abnormal mesoderm development	J:16247
	abnormal neural tube morphology	J:16247
	abnormal vasculogenesis	J:16247
	abnormal visceral yolk sac morphology	J:16247
	absent notochord	J:16247
	absent somites	J:16247
	absent visceral yolk sac blood islands	J:16247
	absent vitelline blood vessels	J:16247
	decreased cardiac jelly amount	J:16247
	decreased embryo size	J:16247
	embryonic growth retardation	J:16247
	embryonic lethality during organogenesis, complete penetrance	J:16247
	failure of chorioallantoic fusion	J:16247
	failure of initiation of embryo turning	J:16247
	kinked neural tube	J:16247
	short rostral-caudal axis	J:16247
	thick myocardium	J:16247
Fn1^tm1Ksek/Fn1^tm1Ksek involves: 129P2/OlaHsd * 129/Sv	abnormal extracellular matrix morphology	J:93250
	normal cardiovascular system phenotype	J:93027
	decreased fibroblast proliferation	J:93250
	normal neoplasm	J:93027
Fn1^tm1Ref/Fn1^tm1Ref involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:67961
Fn1^tm1Ref/Fn1^tm1Ref Tg(Col2a1-cre)1Asz/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	normal skeleton phenotype	J:85994
Fn1^tm1Ref/Fn1^tm1Ref Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	decreased susceptibility to induced thrombosis	J:82373
	normal homeostasis/metabolism phenotype	J:67961
	increased cerebral infarct size	J:67961
	increased neuron apoptosis	J:67961
	increased susceptibility to ischemic brain injury	J:67961
Fn1^tm2.1Ref/Fn1^tm2.1Ref involves: 129S1/Sv * 129X1/SvJ	abnormal embryonic tissue morphology	J:177821
	abnormal rostral-caudal patterning of the somites	J:177821
	abnormal vitelline vasculature morphology	J:177821
	absent limb buds	J:177821
	normal cardiovascular system phenotype	J:177821
	normal craniofacial phenotype	J:177821
	embryonic lethality during organogenesis, complete penetrance	J:177821
	incomplete embryo turning	J:177821
	incomplete somite formation	J:177821
	increased tail bud apoptosis	J:177821
	kinked neural tube	J:177821
	kinked tail	J:177821
	short rostral-caudal axis	J:177821
Fn1^tm2Bwg/Fn1^tm2Bwg involves: 129S4/SvJae	no abnormal phenotype detected	J:90917
Fn1^tm2Feb/Fn1^tm2Feb involves: 129X1/SvJ	impaired wound healing	J:84274
	premature death	J:84274
	skin lesions	J:84274
	spontaneous skin ulceration	J:84274
Fn1^tm2Hyn/Fn1^tm2Hyn involves: 129S2/SvPas * C57BL/6J	abnormal amnion morphology	J:36210
	abnormal heart morphology	J:36210
	abnormal notochord morphology	J:36210
	abnormal visceral yolk sac morphology	J:36210
	absent somites	J:36210
	absent vitelline blood vessels	J:36210
	embryonic growth retardation	J:36210
	embryonic lethality during organogenesis, complete penetrance	J:36210
	head mesenchyme hypoplasia	J:36210
	kinked neural tube	J:36210
	short rostral-caudal axis	J:36210
Fn1^tm4Hyn/Fn1^tm4Hyn 129S4.129P2-Fn1^tm4Hyn	prenatal lethality, complete penetrance	J:126737
Fn1^tm4Hyn/Fn1^tm4Hyn B6.129P2-Fn1^tm4Hyn	prenatal lethality, incomplete penetrance	J:126737
Fn1^tm4Hyn/Fn1^tm4Hyn involves: 129P2/OlaHsd * C57BL/6J	abnormal atrioventricular cushion morphology	J:126737
	abnormal cardiac outflow tract development	J:126737
	abnormal placenta vasculature	J:126737
	abnormal vascular development	J:126737
	abnormal vascular smooth muscle morphology	J:126737
	abnormal visceral yolk sac morphology	J:126737
	abnormal vitelline vascular remodeling	J:126737
	absent vitelline blood vessels	J:126737
	anemia	J:126737
	disorganized yolk sac vascular plexus	J:126737
	distended pericardium	J:126737
	embryonic lethality during organogenesis, incomplete penetrance	J:126737
	hemorrhage	J:126737
	kinked neural tube	J:126737

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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