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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fos
FBJ osteosarcoma oncogene
MGI:95574
120 phenotypes from 13 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col1a1tm1(tetO-Fos)Wag/Col1a1+
Tg(KRT5-rtTA)T2D6Sgkd/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal forestomach morphology J:201145
absent hair follicles J:201145
alopecia J:201145
decreased body size J:201145
epidermal hyperplasia J:201145
hyperkeratosis J:201145
normal immune system phenotype J:201145
increased CD4-positive, alpha-beta T cell number J:201145
increased granulocyte number J:201145
increased incidence of tumors by chemical induction J:201145
increased keratinocyte proliferation J:201145
increased papilloma incidence J:201145
parakeratosis J:201145
premature death J:201145
skin hyperplasia J:201145
skin inflammation J:201145
skin lesions J:201145
thick skin J:201145
Fosem1(IMPC)Mbp/Fos+
C57BL/6N-Fosem1(IMPC)Mbp/Ucd 		decreased exploration in new environment J:211773
decreased lean body mass J:211773
increased total body fat amount J:211773
no spontaneous movement J:211773
Fosem1(IMPC)Mbp/Fosem1(IMPC)Mbp
C57BL/6N-Fosem1(IMPC)Mbp/Ucd 		abnormal facial morphology J:211773
hemorrhage J:211773
no spontaneous movement J:211773
preweaning lethality, incomplete penetrance J:211773
Fostm1.1(cre/ERT2)Luo/Fos+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:196644
Fostm1Mxu/Fostm1Mxu
Tg(Camk2a-cre)T50Stl/0
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal nervous system electrophysiology J:108041
Fostm1Mxu/Fostm1Mxu
Tg(Drd1-cre)120Mxu/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J 		abnormal behavior J:116774
abnormal dendrite morphology J:116774
abnormal learning/memory/conditioning J:116774
abnormal locomotor activation J:116774
abnormal neuron number J:116774
impaired conditioned place preference behavior J:116774
Fostm1Pa/Fostm1Pa
involves: 129X1/SvJ * C57BL/6J 		abnormal eye electrophysiology J:60736
abnormal frequency of paradoxical sleep J:64368
abnormal long bone diaphysis morphology J:3233
abnormal long bone morphology J:3233
abnormal lymphopoiesis J:3233
abnormal seminiferous tubule morphology J:3233
abnormal sleep duration J:64368
abnormal sleep pattern J:64368
abnormal spatial learning J:19202
abnormal sperm number J:3233
abnormal spermatogenesis J:3233
abnormal tumor morphology J:78834
absent startle reflex J:19202
absent teeth J:3233, J:64368
decreased anxiety-related response J:3233
decreased body size J:3233
decreased fetal weight J:64368
decreased length of long bones J:3233
decreased metastatic potential J:78834
decreased mounting behavior J:18258
decreased placenta weight J:3233
decreased retina rod cell number J:60736
disorganized long bone epiphyseal plate J:3233
domed cranium J:3233
failure of tooth eruption J:3233
hyperactivity J:3233
impaired hearing J:19202
impaired ovarian folliculogenesis J:3233
increased atretic ovarian follicle number J:3233
kinked tail J:3233
neonatal lethality, incomplete penetrance J:3233
premature death J:3233
short snout J:3233
slow postnatal weight gain J:3233
thin retina outer nuclear layer J:60736
Fostm1Wag/Fostm1Wag
involves: 129S2/SvPas 		abnormal bone marrow cavity morphology J:65766
normal behavior/neurological phenotype J:109459
normal craniofacial phenotype J:118753
decreased body size J:65766
decreased fetal size J:65766
decreased osteoclast cell number J:65766
decreased retina apoptosis J:65766
failure of tooth eruption J:65766
osteopetrosis J:65766
perinatal lethality, incomplete penetrance J:65766
normal skeleton phenotype J:118753
Fostm1Wag/Fostm1Wag
involves: 129S2/SvPas * C57BL/6 		abnormal bone marrow cavity morphology J:3493
abnormal compact bone morphology J:3493
abnormal compact bone thickness J:3493
abnormal cytokine secretion J:118693
abnormal long bone epiphyseal plate proliferative zone J:3493
abnormal long bone epiphysis morphology J:3493
abnormal long bone hypertrophic chondrocyte zone J:3493
abnormal long bone metaphysis morphology J:3493
abnormal macrophage physiology J:118693
abnormal spleen morphology J:3493
abnormal spleen white pulp morphology J:3493
abnormal thymus size J:3493
absent teeth J:3493
decreased B cell number J:3493
decreased body weight J:3493
decreased double-positive T cell number J:3493
decreased splenocyte number J:3493
decreased thymocyte number J:3493
failure of tooth eruption J:3493
increased bone trabecula number J:3493
increased macrophage apoptosis J:118693
increased macrophage cytokine production J:118693
increased susceptibility to bacterial infection J:118693
increased T cell number J:3493
osteopetrosis J:3493
short limbs J:3493
short snout J:3493
tooth impaction J:3493
transmission ratio distortion J:3493
Fostm3.1Wag/Fostm3.1Wag
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased interleukin-10 secretion J:175064
increased susceptibility to endotoxin shock J:175064
increased tumor necrosis factor secretion J:175064
Fostm4.1Wag/Fostm4.1Wag
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased interleukin-10 secretion J:175064
increased interleukin-6 secretion J:175064
increased susceptibility to endotoxin shock J:175064
increased tumor necrosis factor secretion J:175064
Fostm5.1Wag/Fostm5.1Wag
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal osteoclast differentiation J:175064
decreased interleukin-10 secretion J:175064
decreased osteoblast cell number J:175064
decreased osteoclast cell number J:175064
increased bone trabecula number J:175064
increased bone volume J:175064
increased circulating tumor necrosis factor level J:175064
increased interleukin-6 secretion J:175064
increased susceptibility to endotoxin shock J:175064
increased tumor necrosis factor secretion J:175064
Fostm6.1Wag/Fostm6.1Wag
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal osteoclast differentiation J:175064
increased circulating interleukin-6 level J:175064
increased circulating interleukin-10 level J:175064
increased circulating tumor necrosis factor level J:175064
increased susceptibility to endotoxin shock J:175064
Fostm7Wag/Fostm7Wag
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:85928
Fostm7Wag/Fostm7Wag
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		decreased interleukin-10 secretion J:175064
increased circulating interleukin-6 level J:175064
increased circulating interleukin-10 level J:175064
increased circulating tumor necrosis factor level J:175064
increased interleukin-6 secretion J:175064
increased susceptibility to endotoxin shock J:175064
increased tumor necrosis factor secretion J:175064
Fostm7Wag/Fostm7Wag
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:190150
decreased cell proliferation J:190150
decreased susceptibility to induced morbidity/mortality J:190150
decreased tumor growth/size J:190150
increased apoptosis J:190150
Fostm7Wag/Fostm7Wag
Tg(Nes-cre)1Kln/?
involves: 129P2/OlaHsd 		abnormal associative learning J:85928
abnormal contextual conditioning behavior J:85928
abnormal spatial learning J:85928
reduced long-term potentiation J:85928
Tg(CD2-Fos)#Liux/0
Not Specified 		decreased apoptosis J:190150
increased susceptibility to induced morbidity/mortality J:190150
increased tumor growth/size J:190150
Tg(Fos/lacZ)#Jim/0
involves: C3H * C57BL/6 * DBA/2 		no abnormal phenotype detected J:237479
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory