Fth1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fth1
ferritin heavy polypeptide 1
MGI:95588

24 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Fth1^tm1.1Lck/Fth1^tm1.1Lck involves: 129/Sv * C57BL/6 * SJL	abnormal liver iron level	J:166515
	normal liver/biliary system phenotype	J:166515
Fth1^{tm1.1(KOMP)Vlcg}/Fth1⁺ C57BL/6N-Fth1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal eye morphology	J:211773
Fth1^{tm1.1(KOMP)Vlcg}/Fth1^{tm1.1(KOMP)Vlcg} C57BL/6N-Fth1^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Fth1^tm1.1Lck/Fth1^tm1.1Lck Tg(Mx1-cre)1Cgn/0 B6.Cg-Fth1^tm1.1Lck Tg(Mx1-cre)1Cgn	abnormal iron homeostasis	J:166515
	decreased spleen iron level	J:166515
	increased circulating alanine transaminase level	J:166515
	increased circulating aspartate transaminase level	J:166515
	increased circulating iron level	J:166515
	increased liver weight	J:166515
	increased susceptibility to induced morbidity/mortality	J:166515
	liver hemorrhage	J:166515
	liver inflammation	J:166515
	macrovesicular hepatic steatosis	J:166515
Fth1^tm1.1Ruvi/Fth1^tm1.1Ruvi involves: 129 * C57BL/6	prenatal lethality, complete penetrance	J:244236
Fth1^tm1.2Lck/Fth1^tm1.2Lck involves: 129/Sv * C57BL/6 * FVB/N	prenatal lethality, complete penetrance	J:166515
Fth1^tm1Cbea/Fth1⁺ involves: 129S2/SvPas * C57BL/6	abnormal iron homeostasis	J:70685
Fth1^tm1Cbea/Fth1⁺ involves: 129S2/SvPas * C57BL/6	increased circulating ferritin level	J:70685
Fth1^tm1Cbea/Fth1^tm1Cbea involves: 129S2/SvPas * C57BL/6	embryonic lethality, complete penetrance	J:60287
Fth1^tm1Kjt/Fth1⁺ involves: 129S/SvEvBrd * C57BL/6	abnormal neuron physiology	J:158718
Fth1^tm1Kjt/Fth1⁺ involves: 129S/SvEvBrd * C57BL/6	oxidative stress	J:158718
Fth1^tm1Kjt/Fth1^tm1Kjt involves: 129S/SvEvBrd * C57BL/6	prenatal lethality, complete penetrance	J:158718
Fth1^tm1Lck/Fth1^tm1Lck involves: 129/Sv * C57BL/6 * FVB/N	abnormal cell physiology	J:166515
	abnormal mitochondrial physiology	J:166515
	increased sensitivity to induced cell death	J:166515

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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