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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fyn
Fyn proto-oncogene
MGI:95602
98 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fyntm1a(EUCOMM)Wtsi/Fyntm1a(EUCOMM)Wtsi
C57BL/6N-Fyntm1a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Fyntm1Fam/Fyntm1Fam
involves: C57BL/6 		abnormal myelination J:109485
Fyntm1Rmp/Fyntm1Rmp
B6.129S2-Fyntm1Rmp 		abnormal eosinophil physiology J:114287
abnormal interleukin-4 secretion J:114287
decreased IgE level J:114287
decreased interleukin-2 secretion J:114287
increased interleukin-5 secretion J:114287
increased susceptibility to type I hypersensitivity reaction J:114287
Fyntm1Rmp/Fyntm1Rmp
involves: 129S2/SvPas 		decreased gamma-delta T cell number J:37062
decreased T cell number J:37062
Fyntm1Rmp/Fyntm1Rmp
involves: 129S2/SvPas * C57BL/6 		abnormal T cell activation J:70886
abnormal thymocyte activation J:70886
decreased T cell proliferation J:70886
Fyntm1Sor/Fyn+
Tg(Camk2a-Fyn-531)1Nko/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal motor capabilities/coordination/movement J:59490
premature death J:59490
tonic seizures J:59490
Fyntm1Sor/Fyntm1Sor
B6.129S7-Fyntm1Sor 		abnormal CD4-positive, alpha-beta T cell physiology J:93886
abnormal NK cell physiology J:187430
abnormal T cell proliferation J:93886
decreased IgE level J:93886
decreased interferon-gamma secretion J:187430
Fyntm1Sor/Fyntm1Sor
either: 129S7/SvEvBrd-Fyntm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal dentate gyrus morphology J:3417
abnormal hippocampus pyramidal cell layer J:3417
abnormal hippocampus pyramidal cell morphology J:3417
abnormal immune cell physiology J:2242
abnormal spatial learning J:3417
abnormal T cell clonal deletion J:2242
abnormal T cell physiology J:2242
abnormal thymocyte activation J:2242
decreased interleukin-2 secretion J:2242
decreased T cell proliferation J:2242
increased hippocampus pyramidal cell number J:3417
increased IgG2a level J:2242
increased IgM level J:2242
reduced long-term potentiation J:3417
Fyntm1Sor/Fyntm1Sor
involves: 129S7/SvEvBrd 		abnormal chemokine level J:80658
abnormal macrophage physiology J:80658
Fyntm1Sor/Fyntm1Sor
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal dentate gyrus morphology J:80637
abnormal hippocampus morphology J:80637
abnormal hippocampus pyramidal cell layer J:80637
abnormal hippocampus pyramidal cell morphology J:80637
abnormal myelination J:109485
abnormal optic nerve morphology J:109485
abnormal sperm capacitation J:185783
abnormal sperm connecting piece morphology J:185783
abnormal sperm head morphology J:185783
abnormal sperm motility J:185783
abnormal spermatogenesis J:185783
abnormal spermiogenesis J:185783
decreased corpus callosum size J:109485
decreased epididymis weight J:185783
decreased fertilization frequency J:185783
ectopic hippocampus pyramidal cells J:80637
impaired acrosome reaction J:185783
impaired sperm penetration of zona pellucida J:185783
oligozoospermia J:185783
reduced long-term potentiation J:80637
normal reproductive system phenotype J:185783
teratozoospermia J:185783
Fyntm1Sor/Fyntm1Sor
Tg(Camk2a-Fyn)1Kndl/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal dentate gyrus morphology J:80637
abnormal hippocampus morphology J:80637
abnormal hippocampus pyramidal cell layer J:80637
abnormal hippocampus pyramidal cell morphology J:80637
ectopic hippocampus pyramidal cells J:80637
Fyntm1Yik/Fyn+
involves: C57BL/6 * CBA 		prolonged circadian behavior period J:63170
Fyntm1Yik/Fyntm1Yik
involves: C57BL/6 * CBA 		abnormal cytokine secretion J:99347
abnormal ectoplasmic specialization morphology J:74017
abnormal excitatory postsynaptic potential J:43707
abnormal hippocampus layer morphology J:16461
abnormal hypothalamus morphology J:63170
abnormal interleukin secretion J:99347
abnormal locomotor circadian rhythm J:63170
abnormal maternal nurturing J:101992
abnormal myelination J:16847
abnormal olfaction J:101992
abnormal olfactory bulb morphology J:16461
abnormal pup retrieval J:101992
abnormal seminiferous tubule morphology J:74017
abnormal somatosensory cortex morphology J:103576
abnormal startle reflex J:74705
abnormal stratification in cerebral cortex J:103576
abnormal suckling behavior J:16461
audiogenic seizures J:23384
decreased testis weight J:74017
enhanced behavioral response to alcohol J:43707
enhanced passive avoidance behavior J:21225
increased dopamine level J:74705
increased fear-related response J:21225, J:74705
increased serotonin level J:74705
increased susceptibility to experimental autoimmune uveoretinitis J:99347
increased susceptibility to xenobiotic induced morbidity/mortality J:101992
increased tumor necrosis factor secretion J:99347
oligozoospermia J:74017
prolonged circadian behavior period J:63170
small seminiferous tubules J:74017
Tg(Camk2a-Fyn-531)1Nko/0
B6.Cg-Tg(Camk2a-Fyn-531)1Nko 		abnormal locomotor behavior J:79980
alcohol aversion J:79980
decreased anxiety-related response J:79980
decreased behavioral withdrawal response J:79980
impaired behavioral response to alcohol J:79980
Tg(Camk2a-Fyn-531)1Nko/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal kindling response J:59490
abnormal motor capabilities/coordination/movement J:59490
abnormal seizure response to electrical stimulation J:59490
increased susceptibility to pharmacologically induced seizures J:59490
premature death J:59490
tonic seizures J:59490
Tg(Krt14-Fyn)AJsey/0
involves: C57BL/6 * CBA 		abnormal filiform papillae morphology J:118155
abnormal keratinocyte morphology J:118155
decreased body size J:118155
decreased eating frequency J:118155
epidermal hyperplasia J:118155
postnatal lethality J:118155
psoriasis J:118155
thick epidermis J:118155
Tg(KRT14-Fyn*)aJsey/0
involves: C57BL/6 * CBA 		abnormal keratinocyte morphology J:155536
epidermal hyperplasia J:155536
increased skin squamous cell carcinoma incidence J:155536
thick epidermis J:155536
Tg(KRT14-Fyn*)aJsey/0
involves: C57BL/6 * CBA * FVB/N 		abnormal keratinocyte differentiation J:155536
abnormal keratinocyte morphology J:155536
epidermal hyperplasia J:155536
hyperkeratosis J:155536
increased skin squamous cell carcinoma incidence J:155536
parakeratosis J:155536
thick epidermis J:155536
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory