Fyn Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fyn
Fyn proto-oncogene
MGI:95602

46 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)	abnormal B cell differentiation	J:115080
	abnormal pro-B cell differentiation	J:115080
	arrested B cell differentiation	J:115080
	decreased B cell number	J:115080
	decreased immature B cell number	J:115080
	decreased pre-B cell number	J:115080
Fyn^tm1Rmp/Fyn^tm1Rmp Lck^tm1Mak/Lck^tm1Mak involves: 129S2/SvPas	abnormal alpha-beta intraepithelial T cell morphology	J:112977
	abnormal NK T cell number	J:37940
	absent CD4-positive, alpha-beta T cells	J:37940
	absent CD8-positive, alpha-beta T cells	J:37940
	absent T cells	J:37062
	arrested T cell differentiation	J:37062, J:37940
	decreased double-positive T cell number	J:37940
	decreased gamma-delta intraepithelial T cell number	J:37940, J:112977
	thymus hypoplasia	J:37062, J:37940
Fyn^tm1Sor/Fyn^tm1Sor Lck^tm1Litt/Lck^tm1.1Litt Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal regulatory T cell physiology	J:152472
	decreased regulatory T cell number	J:152472
	decreased T cell proliferation	J:152472
	enlarged lymph nodes	J:152472
	increased regulatory T cell number	J:152472
	increased T cell number	J:152472
Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺ involves: 129S7/SvEvBrd	abnormal nursing	J:20346
	reduced female fertility	J:20346
Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src^tm1Sor involves: 129S7/SvEvBrd	decreased body size	J:20346
	decreased body weight	J:20346
	postnatal lethality, complete penetrance	J:20346
Fyn^tm1Sor/Fyn^tm1Sor Yes1^tm1Sor/Yes1^tm1Sor involves: 129S7/SvEvBrd	abnormal dentate gyrus morphology	J:20346
	abnormal hippocampus morphology	J:20346
	abnormal kidney morphology	J:20346
	abnormal renal glomerulus morphology	J:20346
	abnormal renal tubule morphology	J:20346
	cortical renal glomerulopathies	J:20346
	decreased body size	J:20346
	enlarged spleen	J:20346
	extramedullary hematopoiesis	J:20346
	glomerulosclerosis	J:20346
	increased spleen white pulp amount	J:20346
	increased urine protein level	J:20346
	myeloid hyperplasia	J:20346
	postnatal lethality, incomplete penetrance	J:20346
	ruffled hair	J:20346
	small kidney	J:20346
	weight loss	J:20346
Fyn^tm1Yik/Fyn^tm1Yik Ptk2^tm1Lfr/Ptk2⁺ involves: 129X1/SvJ * C57BL/6 * CBA	abnormal T cell differentiation	J:110771
	decreased double-positive T cell number	J:110771
	decreased thymocyte number	J:110771
	thymus cortex atrophy	J:110771
Lck^tm1Mak/Lck^tm1Mak Rag1^tm1Mom/Rag1⁺ Tg(Lck-FynY528F)5525Cjg/0 involves: 129S2/SvPas 129S7/SvEvBrd * C57BL/6	abnormal T cell differentiation	J:37062
	decreased T cell number	J:37062

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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