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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6
MGI:95606
38 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Xrcc6avon/Xrcc6avon
involves: C57BL/6JAnu 		decreased B cell number J:104190
decreased T cell number J:104190
Xrcc6tm1Fwa/Xrcc6tm1Fwa
involves: 129S6/SvEvTac 		abnormal brainstem morphology J:110848
abnormal cell physiology J:110848
abnormal diencephalon morphology J:110848
abnormal striatum morphology J:110848
increased neuron apoptosis J:110848
normal nervous system phenotype J:110848
Xrcc6tm1Fwa/Xrcc6tm1Fwa
involves: 129S6/SvEvTac * C57BL/6J 		abnormal B cell differentiation J:44361
abnormal B cell morphology J:44361
abnormal cell physiology J:44361
abnormal nursing J:44361
abnormal T cell differentiation J:44361
abnormal T cell morphology J:44361
absent immature B cells J:44361
absent mature B cells J:44361
absent pre-B cells J:44361
arrested B cell differentiation J:44361
decreased body size J:44361
decreased cell proliferation J:44361
decreased IgM level J:44361
decreased single-positive T cell number J:44361
decreased thymocyte number J:44361
early cellular replicative senescence J:44361
increased cellular sensitivity to gamma-irradiation J:44361
increased double-positive T cell number J:44361
increased T cell derived lymphoma incidence J:44361
slow postnatal weight gain J:44361
Xrcc6tm1Gcl/Xrcc6tm1Gcl
involves: 129S1/Sv * C57BL/6 		abnormal B cell differentiation J:108657
abnormal bone marrow cell morphology/development J:108657
abnormal cell physiology J:108657
abnormal immune system organ morphology J:108657
absent mature B cells J:108657
decreased litter size J:108657
decreased spleen white pulp amount J:108657
increased cellular sensitivity to ionizing radiation J:108657
proportional dwarf J:108657
small lymph nodes J:108657
small spleen J:108657
small thymus J:108657
spleen hypoplasia J:108657
thymus hypoplasia J:108657
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory