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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
MGI:95613
37 phenotypes from 10 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gabra1tm1.1Geh/Gabra1+
B6.129(Cg)-Gabra1tm1.1Geh 		abnormal miniature inhibitory postsynaptic currents J:227437
abnormal spike wave discharge J:186685, J:227437
absence seizures J:186685, J:227437
decreased miniature inhibitory postsynaptic current amplitude J:227437
increased susceptibility to pharmacologically induced seizures J:227437
myoclonus J:227437
seizures J:227437
tonic-clonic seizures J:227437
Gabra1tm1.1Geh/Gabra1+
D2.129(Cg)-Gabra1tm1.1Geh 		abnormal spike wave discharge J:186685
absence seizures J:186685
Gabra1tm1.1Geh/Gabra1tm1.1Geh
B6.129(Cg)-Gabra1tm1.1Geh 		preweaning lethality, incomplete penetrance J:186685
weight loss J:186685
Gabra1tm1.1Geh/Gabra1tm1.1Geh
D2.129(Cg)-Gabra1tm1.1Geh 		preweaning lethality, incomplete penetrance J:186685
weight loss J:186685
Gabra1tm1.1Geh/Gabra1tm1.1Geh
involves: 129S1/Sv * 129X1/SvJ 		abnormal synapse morphology J:199326
Gabra1tm1.1Geh/Gabra1tm1.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal hearing/vestibular/ear phenotype J:112951
Gabra1tm1.1Geh/Gabra1tm1.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal inhibitory postsynaptic currents J:70505, J:103381
decreased physiological sensitivity to xenobiotic J:103381
Gabra1tm1.1Geh/Gabra1tm1.1Mjga
B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga 		postnatal lethality J:227437
Gabra1tm1.1Mjga/Gabra1+
B6J.Cg-Gabra1tm1.1Mjga 		abnormal miniature inhibitory postsynaptic currents J:227437
abnormal spike wave discharge J:227437
absence seizures J:227437
decreased miniature inhibitory postsynaptic current amplitude J:227437
increased susceptibility to pharmacologically induced seizures J:227437
myoclonus J:227437
seizures J:227437
tonic-clonic seizures J:227437
Gabra1tm1.1Mjga/Gabra1tm1.1Mjga
B6J.Cg-Gabra1tm1.1Mjga 		postnatal lethality J:227437
Gabra1tm1.1Uru/Gabra1tm1.1Uru
either: 129X1.129P2-Gabra1tm1.1Uru or B6.129P2-Gabra1tm1.1Uru 		abnormal physiological response to xenobiotic J:75895
abnormal spatial reference memory J:75895
impaired behavioral response to xenobiotic J:75895
increased susceptibility to pharmacologically induced seizures J:75895
Gabra1tm1Geh/Gabra1tm1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		no abnormal phenotype detected J:103381
Gabra1tm1Rmck/Gabra1tm1Rmck
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal behavioral response to xenobiotic J:62214
Gabra1tm1Twr/Gabra1tm1Twr
involves: 129S7/SvEvBrd * C57BL/6 		abnormal GABA-mediated receptor currents J:69290
abnormal physiological response to xenobiotic J:69290
normal behavior/neurological phenotype J:69290
decreased body weight J:69290
decreased litter size J:69290
perinatal lethality, incomplete penetrance J:69290
poor grooming J:69290
tremors J:69290
Gabra1tm2.1Geh/Gabra1+
involves: 129X1/SvJ * C57BL/6J 		abnormal inhibitory postsynaptic currents J:105293
abnormal locomotor activation J:105293
abnormal locomotor behavior J:105293
abnormal maternal nurturing J:105293
decreased body weight J:105293
hunched posture J:105293
hyperresponsive J:105293
impaired coordination J:105293
postnatal lethality, incomplete penetrance J:105293
premature death J:105293
tremors J:105293
Gabra1tm2Geh/Gabra1+
involves: 129X1/SvJ * C57BL/6J 		impaired coordination J:105293
Gabra1tm2Geh/Gabra1tm2Geh
involves: 129X1/SvJ * C57BL/6J 		abnormal locomotor activation J:105293
abnormal locomotor behavior J:105293
decreased body weight J:105293
hunched posture J:105293
hyperresponsive J:105293
impaired coordination J:105293
increased startle reflex J:105293
premature death J:105293
tremors J:105293
Gabra1tm3Geh/Gabra1tm3Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:110982
Gabra1tm4Geh/Gabra1tm4Geh
involves: 129X1/SvJ * C57BL/6 * SJL 		normal behavior/neurological phenotype J:144692
increased exploration in new environment J:144692
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory