About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gabrb3
GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3
MGI:95621
75 phenotypes from 5 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gabrb3tm1Geh/Gabrb3tm1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal auditory brainstem response waveform shape J:112951
abnormal CNS synaptic transmission J:39801
abnormal cochlea morphology J:112951
abnormal cochlear IHC afferent innervation pattern J:112951
abnormal cochlear nerve morphology J:112951
abnormal cochlear OHC efferent innervation pattern J:112951
abnormal motor capabilities/coordination/movement J:39801
abnormal parental behavior J:39801
circling J:39801, J:108890
cleft palate J:39801
cochlear ganglion degeneration J:112951
cochlear ganglion hypoplasia J:108890
cochlear inner hair cell degeneration J:112951
cochlear outer hair cell degeneration J:112951
decreased body size J:39801
hyperactivity J:39801
hyperresponsive J:39801
impaired coordination J:39801
impaired swimming J:39801
increased or absent distortion product otoacoustic emission threshold J:112951
increased or absent threshold for auditory brainstem response J:112951
limb grasping J:39801
perinatal lethality, incomplete penetrance J:39801
premature death J:39801
seizures J:39801
sensorineural hearing loss J:112951
small cochlear ganglion J:108890
small vestibular ganglion J:108890
type IV spiral ligament fibrocyte degeneration J:112951
vestibular ganglion hypoplasia J:108890
Gabrb3tm1Geh/Gabrb3tm1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal behavior J:130259
abnormal cerebellum vermis lobule II morphology J:130259
abnormal cerebellum vermis lobule III morphology J:130259
abnormal cerebellum vermis lobule IV morphology J:130259
abnormal cerebellum vermis lobule morphology J:130259
abnormal cerebellum vermis lobule V morphology J:130259
abnormal cerebellum vermis lobule VI morphology J:130259
abnormal cerebellum vermis lobule VII morphology J:130259
abnormal nest building behavior J:130259
abnormal response to novel object J:130259
abnormal social/conspecific interaction behavior J:130259
circling J:130259
decreased vertical activity J:130259
increased locomotor activity J:130259
Gabrb3tm1Uru/Gabrb3tm1Uru
involves: 129X1/SvJ * C57BL/6J 		abnormal action potential J:81497, J:105539
abnormal CNS synaptic transmission J:105539
abnormal GABA-mediated receptor currents J:81497
abnormal reflex J:81497
abnormal righting response J:81497
normal behavior/neurological phenotype J:81497
impaired behavioral response to xenobiotic J:81497
tremors J:81497
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:127877
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
Tg(Camk2a-cre)T29-1Stl/?
involves: 129 * BALB/c * C57BL/6 * SJL 		abnormal behavior J:127877
abnormal maternal nurturing J:127877
absence seizures J:127877
hyperactivity J:127877
impaired behavioral response to xenobiotic J:127877
increased food intake J:127877
obese J:127877
postnatal lethality, incomplete penetrance J:127877
reduced female fertility J:127877
reduced male fertility J:127877
reduced male mating frequency J:127877
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal CD4-positive T cell differentiation J:333883
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:333883
abnormal T-helper 17 cell differentiation J:333883
immune system phenotype J:333883
increased susceptibility to experimental autoimmune encephalomyelitis J:333883
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
Tg(Syn1-cre)671Jxm/?
involves: 129 * C57BL/6 * CBA * SJL 		normal behavior/neurological phenotype J:127877
impaired behavioral response to xenobiotic J:127877
postnatal lethality, incomplete penetrance J:127877
Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
B6J.129S6(Cg)-Gabrb3tm2.1Uru 		abnormal CNS synaptic transmission J:228332
abnormal dentate gyrus neuron dendrite morphology J:228332
abnormal hippocampus neuron morphology J:228332
abnormal inhibitory postsynaptic potential J:228332
abnormal response to social novelty J:228332
normal behavior/neurological phenotype J:228332
enhanced contextual conditioning behavior J:228332
increased excitatory postsynaptic current amplitude J:228332
increased stereotypic behavior J:228332
increased susceptibility to pharmacologically induced seizures J:228332
prolonged excitatory postsynaptic current decay time J:228332
Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		cleft palate J:127877
lethality at weaning, complete penetrance J:127877
neonatal lethality, incomplete penetrance J:127877
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory