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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gabrg2
gamma-aminobutyric acid type A receptor, subunit gamma 2
MGI:95623
52 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gabrg2em1(IMPC)Mbp/Gabrg2+
C57BL/6NCrl-Gabrg2em1(IMPC)Mbp/MbpMmucd 		abnormal ovary morphology J:211773
abnormal retina morphology J:211773
abnormal skin morphology J:211773
abnormal testis morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased heart weight J:211773
enlarged testis J:211773
persistence of hyaloid vascular system J:211773
Gabrg2em1(IMPC)Mbp/Gabrg2em1(IMPC)Mbp
C57BL/6NCrl-Gabrg2em1(IMPC)Mbp/MbpMmucd 		preweaning lethality, complete penetrance J:211773
Gabrg2tm1.1Stmo/Gabrg2+
B6.129S2-Gabrg2tm1.1Stmo 		abnormal miniature inhibitory postsynaptic currents J:154745
abnormal spatial reference memory J:154745
abnormal synapse morphology J:154745
normal behavior/neurological phenotype J:154745
increased miniature inhibitory postsynaptic current amplitude J:154745
increased miniature inhibitory postsynaptic current frequency J:154745
Gabrg2tm1.1Stmo/Gabrg2tm1.1Stmo
B6.129S2-Gabrg2tm1.1Stmo 		embryonic lethality, complete penetrance J:154745
Gabrg2tm1.2Rmac/Gabrg2+
involves: C57BL/6 * C57BL/6J * SJL 		abnormal nervous system electrophysiology J:306976
absence seizures J:306976
decreased miniature inhibitory postsynaptic current amplitude J:306976
febrile seizures J:306976
increased locomotor activity J:306976
increased susceptibility to pharmacologically induced seizures J:306976
increased vertical activity J:306976
myoclonus J:306976
seizures J:306976
sudden unexpected death in epilepsy J:306976
tonic-clonic seizures J:306976
Gabrg2tm1Dc/Gabrg2tm1Dc
involves: 129P2/OlaHsd * C57BL/6J 		decreased physiological sensitivity to xenobiotic J:97175
impaired behavioral response to xenobiotic J:97175
Gabrg2tm1Geh/Gabrg2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		reduced male fertility J:53823
normal reproductive system phenotype J:53823
Gabrg2tm1Geh/Gabrg2tm1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal GABA-mediated receptor currents J:53823
abnormal xenobiotic pharmacokinetics J:102772
normal behavior/neurological phenotype J:53823
enhanced behavioral response to xenobiotic J:102772
Gabrg2tm1Lusc/Gabrg2tm1Lusc
involves: 129P2/OlaHsd * C57BL/6 		abnormal gait J:28662
hyperactivity J:28662
impaired righting response J:28662
limb grasping J:28662
normal nervous system phenotype J:28662
postnatal lethality, complete penetrance J:28662
Gabrg2tm1Spet/Gabrg2+
involves: 129 * BALB/cJ * C57BL/6 * DBA/2J 		abnormal inhibitory postsynaptic currents J:127120
absence seizures J:127120
Gabrg2tm1Spet/Gabrg2+
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ 		increased susceptibility to pharmacologically induced seizures J:194736
Gabrg2tm1Spet/Gabrg2+
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal inhibitory postsynaptic currents J:127120
absence seizures J:127120
increased susceptibility to pharmacologically induced seizures J:127120
Gabrg2tm1Spet/Gabrg2tm1Spet
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal brain wave pattern J:127120
abnormal gait J:127120
perinatal lethality, incomplete penetrance J:127120
postnatal lethality, complete penetrance J:127120
tremors J:127120
Gabrg2tm1Wul/Gabrg2tm1Wul
Hdctm1.1(icre)Wwis/Hdc+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal GABA-mediated receptor currents J:188103
abnormal inhibitory postsynaptic currents J:188103
abnormal neuron physiology J:188103
normal behavior/neurological phenotype J:188103
Gabrg2tm1Wul/Gabrg2tm1Wul
Tg(Pcp2-cre)2Mpin/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal inhibitory postsynaptic currents J:124171
normal behavior/neurological phenotype J:124171
impaired behavioral response to xenobiotic J:124171
Gabrg2tm1Wul/Gabrg2tm1Wul
Tg(Pcp2-cre)2Mpin/?
Tg(Pcp2-EGFP/Gabrg2)1Wul/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal inhibitory postsynaptic currents J:124171
impaired behavioral response to xenobiotic J:124171
impaired coordination J:124171
Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		postnatal lethality, complete penetrance J:98560
Gabrg2tm2Geh/Gabrg2tm2Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		increased anxiety-related response J:98560
Gabrg2tm2Lusc/Gabrg2tm2Lusc
involves: 129P2/OlaHsd * 129X1/SvJ 		no abnormal phenotype detected J:86221
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129X1/SvJ 		decreased locomotor activity J:86221
premature death J:86221
seizures J:86221
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)T50Stl/0
involves: 129X1/SvJ * BALB/c * C57BL/6 		premature death J:86221
Gabrg2tm2Spet/Gabrg2+
involves: 129S1/Sv * 129X1/SvJ 		decreased susceptibility to pharmacologically induced seizures J:194196
Gabrg2tm2Spet/Gabrg2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)LC1Bjd/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		increased susceptibility to pharmacologically induced seizures J:194736
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory