Slc6a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
MGI:95627

30 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc6a1^tm1.1Lst/Slc6a1^tm1.1Lst involves: 129S1/Sv	no abnormal phenotype detected	J:80438
Slc6a1^tm1Lst/Slc6a1^tm1Lst involves: 129S1/Sv * C57BL/6	abnormal inhibitory postsynaptic currents	J:95639
	abnormal neurotransmitter secretion	J:95639
	abnormal neurotransmitter uptake	J:95639
Slc6a1^tm1Mlit/Slc6a1⁺ involves: 129S1/Sv * C57BL/6	abnormal bitter taste sensitivity	J:144919
	abnormal conditioned taste aversion behavior	J:144919
	abnormal contextual conditioning behavior	J:144919
	alcohol preference	J:144919
	decreased locomotor activity	J:144919
	hyperactivity elicited by ethanol administration	J:144919
	increased alcohol consumption	J:144919
	saccharin preference	J:144919
Slc6a1^tm1Mlit/Slc6a1^tm1Mlit B6.129S1-Slc6a1^tm1Mlit	abnormal GABA-mediated receptor currents	J:204368
	abnormal latent inhibition of conditioning behavior	J:204368
	abnormal object recognition memory	J:204368
	abnormal response to novel object	J:204368
	abnormal social/conspecific interaction behavior	J:204368
	decreased prepulse inhibition	J:204368
	enhanced behavioral response to xenobiotic	J:204368
	impaired cued conditioning behavior	J:204368
	impaired spatial working memory	J:204368
	increased locomotor activity	J:204368
	normal nervous system phenotype	J:204368
	reduced sensorimotor gating	J:204368
Slc6a1^tm1Mlit/Slc6a1^tm1Mlit involves: 129S1/Sv * C57BL/6	abnormal behavioral response to xenobiotic	J:144919
	abnormal bitter taste sensitivity	J:144919
	abnormal conditioned taste aversion behavior	J:144919
	ataxia	J:144919
	decreased body weight	J:144919
	hyperactivity	J:144919
	increased startle reflex	J:144919
	tremors	J:144919

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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