About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gad1
glutamate decarboxylase 1
MGI:95632
51 phenotypes from 9 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Drd1tm1(cre)Rpa/Drd1+
Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6 		abnormal motor coordination/balance J:138586
normal behavior/neurological phenotype J:138586
decreased grip strength J:138586
limb grasping J:138586
Gad1tm1.1Bgc/Gad1tm1.1Bgc
involves: 129S6/SvEvTac 		cleft secondary palate J:158888
failure of palatal shelf elevation J:158888
umbilical hernia J:158888
Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		cleft secondary palate J:158888
umbilical hernia J:158888
Gad1tm1.1Rpa/Gad1+
Not Specified 		abnormal brain interneuron morphology J:126581
Gad1tm1.1Rpa/Gad1tm1.1Rpa
Not Specified 		perinatal lethality, complete penetrance J:126581, J:138586
Gad1tm1.1Tama/Gad1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal nervous system phenotype J:134533
Gad1tm1Mrc/Gad1tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal suckling behavior J:43954
cleft secondary palate J:43954
cyanosis J:43954
dehydration J:43954
hypoxia J:43954
meteorism J:43954
narrow maxilla J:43954
neonatal lethality, complete penetrance J:43954
palatal shelves fail to meet at midline J:43954
Gad1tm1Oba/Gad1+
involves: C57BL/6 * CBA 		decreased gamma-aminobutyric acid level J:40978
decreased glutamate decarboxylase activity J:40978
Gad1tm1Oba/Gad1tm1Oba
involves: C57BL/6 * CBA 		absent gastric milk in neonates J:40978
atelectasis J:40978
normal behavior/neurological phenotype J:40978
cleft palate J:40978
cyanosis J:40978
decreased gamma-aminobutyric acid level J:40978
decreased glutamate decarboxylase activity J:40978
distended abdomen J:40978
neonatal lethality, complete penetrance J:40978
respiratory distress J:40978
Gad1tm1Rpa/Gad1+
Not Specified 		abnormal brain interneuron morphology J:126581
Gad1tm1Rpa/Gad1tm1Rpa
Not Specified 		no abnormal phenotype detected J:126581
Gad1tm1Rpa/Gad1tm1Rpa
Not Specified 		abnormal brain interneuron morphology J:126581
abnormal visual cortex morphology J:126581
Gad1tm1Tama/Gad1tm1Tama
involves: C57BL/6 * CBA 		abnormal involuntary movement J:100809
abnormal nervous system electrophysiology J:100809
Gad1tm1Zjh/Gad1tm1Zjh
involves: C57BL/6 		lethality, complete penetrance J:226639
Gad1tm2Oba/Gad1tm2Oba
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal gait J:134497
abnormal inhibitory postsynaptic currents J:134497
abnormal nervous system morphology J:134497
normal craniofacial phenotype J:134497
normal endocrine/exocrine gland phenotype J:134497
normal homeostasis/metabolism phenotype J:134497
impaired coordination J:134497
Tg(Npy-EGFP/RNAi:Gad1)1Mirn/?
C57BL/6NHsd-Tg(Npy-EGFP/RNAi:Gad1)1Mirn 		abnormal behavioral response to amphetamine J:227900
abnormal social investigation J:227900
decreased anxiety-related response J:227900
Tg(Cck-EGFP/RNAi:Gad1)2Mirn/?
C57BL/6NHsd-Tg(Cck-EGFP/RNAi:Gad1)2Mirn 		abnormal behavioral response to amphetamine J:227900
abnormal response to novel odor J:227900
decreased locomotor activity J:227900
Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn/?
C57BL/6-Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn 		abnormal behavioral response to amphetamine J:210380
abnormal social investigation J:210380
enhanced cued conditioning behavior J:210380
increased serotonin level J:210380
increased startle reflex J:210380
slow extinction of fear memory J:210380
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/?
C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn 		abnormal GABA-mediated receptor currents J:227902
abnormal response to novel object J:227902
abnormal social investigation J:227902
decreased prepulse inhibition J:227902
decreased vertical activity J:227902
increased startle reflex J:227902
increased vertical activity J:227902
slow extinction of fear memory J:227902
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory