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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gad1
glutamate decarboxylase 1
MGI:95632
51 phenotypes from 9 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Drd1tm1(cre)Rpa/Drd1+
Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6 		abnormal motor coordination/balance J:138586
normal behavior/neurological phenotype J:138586
decreased grip strength J:138586
limb grasping J:138586
Gad1tm1.1Bgc/Gad1tm1.1Bgc
involves: 129S6/SvEvTac 		cleft secondary palate J:158888
failure of palatal shelf elevation J:158888
umbilical hernia J:158888
Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		cleft secondary palate J:158888
umbilical hernia J:158888
Gad1tm1.1Rpa/Gad1+
Not Specified 		abnormal brain interneuron morphology J:126581
Gad1tm1.1Rpa/Gad1tm1.1Rpa
Not Specified 		perinatal lethality, complete penetrance J:126581, J:138586
Gad1tm1.1Tama/Gad1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal nervous system phenotype J:134533
Gad1tm1Mrc/Gad1tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal suckling behavior J:43954
cleft secondary palate J:43954
cyanosis J:43954
dehydration J:43954
hypoxia J:43954
meteorism J:43954
narrow maxilla J:43954
neonatal lethality, complete penetrance J:43954
palatal shelves fail to meet at midline J:43954
Gad1tm1Oba/Gad1+
involves: C57BL/6 * CBA 		decreased gamma-aminobutyric acid level J:40978
decreased glutamate decarboxylase activity J:40978
Gad1tm1Oba/Gad1tm1Oba
involves: C57BL/6 * CBA 		absent gastric milk in neonates J:40978
atelectasis J:40978
normal behavior/neurological phenotype J:40978
cleft palate J:40978
cyanosis J:40978
decreased gamma-aminobutyric acid level J:40978
decreased glutamate decarboxylase activity J:40978
distended abdomen J:40978
neonatal lethality, complete penetrance J:40978
respiratory distress J:40978
Gad1tm1Rpa/Gad1+
Not Specified 		abnormal brain interneuron morphology J:126581
Gad1tm1Rpa/Gad1tm1Rpa
Not Specified 		no abnormal phenotype detected J:126581
Gad1tm1Rpa/Gad1tm1Rpa
Not Specified 		abnormal brain interneuron morphology J:126581
abnormal visual cortex morphology J:126581
Gad1tm1Tama/Gad1tm1Tama
involves: C57BL/6 * CBA 		abnormal involuntary movement J:100809
abnormal nervous system electrophysiology J:100809
Gad1tm1Zjh/Gad1tm1Zjh
involves: C57BL/6 		lethality, complete penetrance J:226639
Gad1tm2Oba/Gad1tm2Oba
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal gait J:134497
abnormal inhibitory postsynaptic currents J:134497
abnormal nervous system morphology J:134497
normal craniofacial phenotype J:134497
normal endocrine/exocrine gland phenotype J:134497
normal homeostasis/metabolism phenotype J:134497
impaired coordination J:134497
Tg(Npy-EGFP/RNAi:Gad1)1Mirn/?
C57BL/6NHsd-Tg(Npy-EGFP/RNAi:Gad1)1Mirn 		abnormal behavioral response to amphetamine J:227900
abnormal social investigation J:227900
decreased anxiety-related response J:227900
Tg(Cck-EGFP/RNAi:Gad1)2Mirn/?
C57BL/6NHsd-Tg(Cck-EGFP/RNAi:Gad1)2Mirn 		abnormal behavioral response to amphetamine J:227900
abnormal response to novel odor J:227900
decreased locomotor activity J:227900
Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn/?
C57BL/6-Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn 		abnormal behavioral response to amphetamine J:210380
abnormal social investigation J:210380
enhanced cued conditioning behavior J:210380
increased serotonin level J:210380
increased startle reflex J:210380
slow extinction of fear memory J:210380
Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/?
C57BL/6-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn 		abnormal GABA-mediated receptor currents J:227902
abnormal response to novel object J:227902
abnormal social investigation J:227902
decreased prepulse inhibition J:227902
decreased vertical activity J:227902
increased startle reflex J:227902
increased vertical activity J:227902
slow extinction of fear memory J:227902
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12/10/2024
MGI 6.24 		The Jackson Laboratory