Gad2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gad2
glutamic acid decarboxylase 2
MGI:95634

27 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gad2^{tm1(cre/ERT2)Zjh}/Gad2⁺ involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:151755
Gad2^tm1.1Ksvo/Gad2^tm1.1Ksvo involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:101977
Gad2^{tm1b(EUCOMM)Wtsi}/Gad2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Gad2^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal behavior	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	decreased respiratory quotient	J:211773
	impaired glucose tolerance	J:211773
	increased anxiety-related response	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating chloride level	J:211773
	increased circulating sodium level	J:211773
	increased fasting circulating glucose level	J:211773
	increased thigmotaxis	J:211773
	increased vertical activity	J:211773
Gad2^tm1Bae/Gad2^tm1Bae involves: 129X1/SvJ	normal nervous system phenotype	J:126581
Gad2^tm1Bae/Gad2^tm1Bae involves: 129X1/SvJ * C57BL/6	normal homeostasis/metabolism phenotype	J:44638
	premature death	J:44638
	normal reproductive system phenotype	J:44638
	seizures	J:44638
Gad2^tm1Bae/Gad2^tm1Bae involves: 129X1/SvJ * NOD	decreased gamma-aminobutyric acid level	J:44638
	premature death	J:44638
	normal reproductive system phenotype	J:44638
	seizures	J:44638
Gad2^tm1Miya/Gad2^tm1Miya NOD.129P2-Gad2^tm1Miya	decreased body weight	J:88785
	increased circulating glucose level	J:88785
	pancreas inflammation	J:88785
	premature death	J:88785
	seizures	J:88785
Gad2^tm1Oba/Gad2⁺ involves: C57BL/6 * CBA	decreased aggression towards male mice	J:62320
	decreased gamma-aminobutyric acid level	J:62320
	increased anxiety-related response	J:62320
	seizures	J:37576
Gad2^tm1Oba/Gad2^tm1Oba involves: C57BL/6 * CBA	decreased aggression towards male mice	J:62320
	decreased gamma-aminobutyric acid level	J:62320
	increased anxiety-related response	J:62320
	increased coping response	J:62320
	myoclonus	J:62320
	normal nervous system phenotype	J:62320
	premature death	J:62320
	seizures	J:37576, J:62320
	tonic-clonic seizures	J:62320
Gad2^tm2(cre)Zjh/Gad2^tm2(cre)Zjh involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:151755

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24