Galc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Galc
galactosylceramidase
MGI:95636

76 phenotypes from 10 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Galc^M1Btlr/Galc⁺ C57BL/6J-Galc^M1Btlr	decreased body weight	J:255205
Galc^M1Btlr/Galc^M1Btlr C57BL/6J-Galc^M1Btlr	decreased body weight	J:255205
Galc^m2Btlr/Galc^m2Btlr C57BL/6J-Galc^m2Btlr	ataxia	J:267485
	decreased body size	J:267485
	decreased heart rate	J:267485
	increased mean systemic arterial blood pressure	J:267485
	increased systemic arterial diastolic blood pressure	J:267485
Galc^m3Btlr/Galc^m3Btlr C57BL/6J-Galc^m3Btlr	ataxia	J:274842
Galc^m3Btlr/Galc^m3Btlr C57BL/6J-Galc^m3Btlr	hindlimb paralysis	J:274842
Galc^m4Btlr/Galc^m4Btlr C57BL/6J-Galc^m4Btlr	abnormal vertebral column morphology	J:307652
	decreased body size	J:307652
	kyphosis	J:307652
Galc^tm1Wngr/Galc^tm1Wngr involves: 129S2/SvPas	abnormal enzyme/coenzyme activity	J:78691
	abnormal immune system physiology	J:78691
	cachexia	J:78691
	demyelination	J:78691
	hindlimb paralysis	J:78691
	premature death	J:78691
	tremors	J:78691
Galc^twi-2J/Galc^twi-2J B10.A-H2ⁱ⁵/(R5)SgSn	abnormal gait	J:78474
Galc^twi-2J/Galc^twi-2J B10.A-H2ⁱ⁵/(R5)SgSn	tremors	J:78474
Galc^twi-4J/Galc^twi-4J involves: C57BL/6J	ataxia	J:137512
Galc^twi-4J/Galc^twi-4J involves: C57BL/6J	tremors	J:137512
Galc^twi-5J/Galc^twi-5J BXD32/TyJ-Galc^twi-5J/J	abnormal axon morphology	J:199132
	abnormal corpus callosum morphology	J:199132
	abnormal leukocyte morphology	J:199132
	abnormal spinal cord morphology	J:199132
	astrocytosis	J:199132
	cachexia	J:139715
	decreased body size	J:139715, J:199132
	demyelination	J:139715, J:199132
	gliosis	J:199132
	postnatal lethality, incomplete penetrance	J:139715
	premature death	J:199132
	slow postnatal weight gain	J:199132
	tremors	J:139715, J:199132
	normal vision/eye phenotype	J:139715
	weakness	J:199132
Galc^twi/Galc^twi-3J involves: C57BL/6J * CE/J	decreased body size	J:30778
Galc^twi/Galc^twi-3J involves: C57BL/6J * CE/J	tremors	J:30778
Galc^twi/Galc^twi B6.CE-Galc^twi/J	abnormal astrocyte morphology	J:108359, J:126892
	abnormal bone remodeling	J:165361
	abnormal brain morphology	J:126892
	abnormal enzyme/coenzyme activity	J:108359
	abnormal forebrain morphology	J:170081
	abnormal gait	J:126892
	abnormal hindbrain morphology	J:126892
	abnormal lipid level	J:165361
	abnormal long bone metaphysis morphology	J:165361
	abnormal microglial cell morphology	J:108359
	abnormal oligodendrocyte morphology	J:170081
	abnormal osteoclast physiology	J:165361
	abnormal sciatic nerve morphology	J:126892
	abnormal skeleton development	J:165361
	abnormal sphingomyelin level	J:165361
	astrocytosis	J:170081
	ataxia	J:108359
	decreased body weight	J:165361
	decreased bone mineral density	J:165361
	decreased bone trabecula number	J:165361
	decreased circulating insulin-like growth factor I level	J:165361
	decreased compact bone thickness	J:165361
	decreased femur size	J:165361
	decreased femur weight	J:165361
	decreased oligodendrocyte number	J:170081
	demyelination	J:108359, J:126892, J:170081
	impaired righting response	J:108359
	increased oligodendrocyte progenitor number	J:170081
	muscle twitch	J:170081
	paraparesis	J:126892
	paresis	J:170081
	premature death	J:108359, J:126892, J:170081
	tremors	J:108359, J:126892
	weight loss	J:170081
Galc^twi/Galc^twi involves: 129P2/OlaHsd * C57BL/6J * CE/J	premature death	J:63197
Galc^twi/Galc^twi Il6⁺/? involves: 129S2/SvPas * C57BL/6J * CE/J	abnormal blood-brain barrier function	J:56656
	abnormal cerebellum white matter morphology	J:56656
	abnormal tumor necrosis factor level	J:56656
	demyelination	J:56656
	gliosis	J:56656
	premature death	J:56656
	tremors	J:56656
Galc^twi/Galc^twi involves: C57BL/6J * CAST/EiJ * CE/J	abnormal astrocyte morphology	J:126892
	abnormal brain morphology	J:126892
	abnormal gait	J:126892
	abnormal hindbrain morphology	J:126892
	abnormal medulla oblongata morphology	J:126892
	abnormal pons morphology	J:126892
	abnormal sciatic nerve morphology	J:126892
	axonal spheroids	J:126892
	demyelination	J:126892
	paraparesis	J:126892
	premature death	J:126892
	tremors	J:126892
Galc^twi/Galc^twi involves: C57BL/6J * CE/J	abnormal macrophage morphology	J:6390
	abnormal myelin sheath morphology	J:6390
	cachexia	J:6390
	premature death	J:6390
	progressive muscle weakness	J:6390
	tremors	J:6390
Galc^twi/Galc^twi involves: CE/J	abnormal brain white matter morphology	J:13867
	abnormal glial cell apoptosis	J:57215
	abnormal kidney development	J:7313
	abnormal kidney epithelium morphology	J:7313
	abnormal kidney morphology	J:7313
	abnormal kidney physiology	J:7311
	abnormal lipid level	J:78223
	abnormal nervous system physiology	J:7115
	abnormal oligodendrocyte morphology	J:57215
	abnormal protein level	J:7311
	abnormal spinal cord white matter morphology	J:13867
	axon degeneration	J:13867
	CNS inflammation	J:78223
	decreased body size	J:13867
	decreased oligodendrocyte number	J:57215
	demyelination	J:13867, J:78223
	edema	J:7115
	hindlimb paralysis	J:13867
	impaired limb coordination	J:13867
	peripheral nervous system degeneration	J:13867
	normal renal/urinary system phenotype	J:7313
	tremors	J:13867

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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