Galc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Galc
galactosylceramidase
MGI:95636

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Csf1^op/Csf1^op Galc^twi/Galc^twi involves: C3HeB/Fe * C57BL/6J * CE/J	abnormal forebrain morphology	J:170081
	abnormal oligodendrocyte morphology	J:170081
	abnormal oligodendrocyte physiology	J:170081
	absent incisors	J:170081
	decreased body size	J:170081
	decreased oligodendrocyte number	J:170081
	decreased oligodendrocyte progenitor number	J:170081
	demyelination	J:170081
	domed cranium	J:170081
	hindlimb paralysis	J:170081
	impaired macrophage chemotaxis	J:170081
	premature death	J:170081
	tremors	J:170081
	weight loss	J:170081
Galc^twi/Galc^twi Glb1^tm1Adz/Glb1⁺ involves: 129P2/OlaHsd * C57BL/6J * CE/J	abnormal lipid level	J:63197
	demyelination	J:63197
	normal immune system phenotype	J:63197
	induced hyperactivity	J:63197
	normal liver/biliary system phenotype	J:63197
	neurodegeneration	J:63197
	premature death	J:63197
	seizures	J:63197
Galc^twi/Galc^twi Glb1^tm1Adz/Glb1^tm1Adz involves: 129P2/OlaHsd * C57BL/6J * CE/J	abnormal lipid level	J:63197
	abnormal liver morphology	J:63197
	abnormal macrophage physiology	J:63197
	abnormal renal glomerular capsule morphology	J:63197
	abnormal renal tubule epithelium morphology	J:63197
	demyelination	J:63197
	enlarged liver	J:63197
	enlarged spleen	J:63197
	premature death	J:63197
Galc^twi/Galc^twi Hpgds^tm1Urad/Hpgds^tm1Urad B6.Cg-Hpgds^tm1Urad Galc^twi	abnormal astrocyte morphology	J:108359
	ataxia	J:108359
	decreased apoptosis	J:108359
	premature death	J:108359
Galc^twi/Galc^twi Il6^tm1Kopf/Il6^tm1Kopf involves: 129S2/SvPas * C57BL/6J * CE/J	abnormal blood-brain barrier function	J:56656
	abnormal cerebellum white matter morphology	J:56656
	abnormal tumor necrosis factor level	J:56656
	gliosis	J:56656
	tremors	J:56656
Galc^twi/Galc^twi Ptgdr^tm1Sna/Ptgdr^tm1Sna B6.Cg-Galc^twi Ptgdr^tm1Sna	abnormal astrocyte morphology	J:108359
	ataxia	J:108359
	premature death	J:108359

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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