Gata2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gata2
GATA binding protein 2
MGI:95662

58 phenotypes from 12 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
En1^tm2(cre)Wrst/En1⁺ Gata2^tm1Msal/Gata2^tm1Msal involves: 129S1/Sv * 129X1/SvJ	abnormal GABAergic neuron morphology	J:143527
	abnormal neuron differentiation	J:143527
	abnormal serotonergic neuron morphology	J:143527
	normal nervous system phenotype	J:143527
Gata2^tm1.1Sac/Gata2^tm1.1Sac involves: 129S1/Sv * 129X1/SvJ	anemia	J:108963
	embryonic lethality, complete penetrance	J:108963
Gata2^{tm1b(KOMP)Wtsi}/Gata2⁺ C57BL/6N-Gata2^{tm1b(KOMP)Wtsi}/Tcp	abnormal auditory brainstem response	J:211773
	abnormal embryo size	J:211773
	abnormal epididymis morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal ovary morphology	J:211773
	absent epididymis	J:211773
	embryonic growth retardation	J:211773
	enlarged epididymis	J:211773
Gata2^{tm1b(KOMP)Wtsi}/Gata2^{tm1b(KOMP)Wtsi} C57BL/6N-Gata2^{tm1b(KOMP)Wtsi}/Tcp	abnormal embryo size	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Gata2^tm1Jeng/Gata2^tm1Jeng involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:106045
Gata2^tm1Mym/Gata2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal definitive hematopoiesis	J:84836
Gata2^tm1Mym/Gata2^tm1Mym involves: 129P2/OlaHsd * C57BL/6	abnormal blood cell morphology/development	J:84836
	abnormal definitive hematopoiesis	J:106045
	embryonic lethality during organogenesis, complete penetrance	J:84836, J:106045
Gata2^tm1Sac/Gata2^tm1Sac Pgr^tm2(cre)Lyd/Pgr⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal decidualization	J:240902
	abnormal endometrium morphology	J:240902
	abnormal uterus physiology	J:240902
	failure of embryo implantation	J:240902
	female infertility	J:240902
Gata2^tm1Sac/Gata2^tm1Sac Tg(Cga-cre)3Sac/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	abnormal pituitary gland development	J:108963
	abnormal pituitary secretion	J:108963
	decreased circulating follicle stimulating hormone level	J:108963
	decreased circulating thyroid-stimulating hormone level	J:108963
	decreased seminal vesicle weight	J:108963
	postnatal growth retardation	J:108963
Gata2^tm1Sho/Gata2^tm1Sho involves: 129S4/SvJae * C57BL/6	abnormal embryonic hematopoiesis	J:20316
	absent vitelline blood vessels	J:20316
	anemia	J:20316
	embryonic lethality during organogenesis, complete penetrance	J:20316
	enlarged pericardium	J:20316
	normal hearing/vestibular/ear phenotype	J:93820
	impaired hematopoiesis	J:20316
	pale yolk sac	J:20316
Gata2^{tm2(Gata2)Jeng}/Gata2^{tm2(Gata2)Jeng} involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA	abnormal kidney morphology	J:138257
	abnormal renal/urinary system morphology	J:138257
	abnormal ureter development	J:138257
	abnormal ureter morphology	J:138257
	decreased body size	J:138257
	decreased body weight	J:138257
	decreased survivor rate	J:138257
	hydronephrosis	J:138257
	large ureter	J:138257
	lethality throughout fetal growth and development, incomplete penetrance	J:138257
	perinatal lethality, incomplete penetrance	J:138257
	postnatal lethality, incomplete penetrance	J:138257
	premature death	J:138257
	renal hypoplasia	J:138257
Gata2^tm2Sho/Gata2^tm2Sho involves: 129S6/SvEvTac * C57BL/6	normal hematopoietic system phenotype	J:77724
Gata2^tm2Sho/Gata2^tm2Sho involves: 129S6/SvEvTac * C57BL/6	normal mortality/aging	J:77724
Gata2^tm3.1Sho/Gata2^tm3.1Sho B6.129S1-Gata2^tm3.1Sho	abnormal stress erythropoiesis	J:165427
	anemia	J:165427
	decreased erythroid progenitor cell number	J:165427
	increased erythroid progenitor cell number	J:165427
Gata2^tm3.1Sho/Gata2^tm3.1Sho involves: 129S1/Sv	normal hematopoietic system phenotype	J:173274
Gata2^tm4.1Sho/Gata2^tm4.1Sho Not Specified	abnormal megakaryocyte progenitor cell morphology	J:173274
	decreased common myeloid progenitor cell number	J:173274
	normal hematopoietic system phenotype	J:173274
Gt(ROSA)26Sor^{tm10(Gata2)Jhai}/Gt(ROSA)26Sor⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA	embryonic lethality	J:194078

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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