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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gata3
GATA binding protein 3
MGI:95663
185 phenotypes from 13 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm1Jfz
involves: 129S1/Sv * 129X1/SvJ 		abnormal cochlear ganglion morphology J:207904
Gata3jal/Gata3+
C3H/HeJ-Gata3jal/J 		abnormal hair texture J:186383
Gata3jal/Gata3jal
C3H/HeJ-Gata3jal/J 		abnormal hair cuticle J:77437
abnormal hair cycle J:77437
abnormal hair follicle morphology J:77437
abnormal hair shaft melanin granule distribution J:77437
abnormal hair shaft morphology J:77437
abnormal hair texture J:77437, J:186383
abnormal vibrissa morphology J:77437
alopecia J:186383
curly vibrissae J:186383
decreased body size J:186383
focal dorsal hair loss J:77437
short vibrissae J:186383
waved hair J:77437, J:186383
Gata3tm1.1Gan/Gata3+
Tg(Pax2-cre)1Akg/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr 		decreased body weight J:199588
Gata3tm1.1Gan/Gata3tm1.1Gan
Tg(Pax2-cre)1Akg/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr 		abnormal cochlea morphology J:199588
abnormal cochlear ganglion morphology J:199588
abnormal cochlear hair cell morphology J:199588
abnormal crista ampullaris morphology J:199588
abnormal inner ear development J:199588
abnormal organ of Corti morphology J:199588
abnormal vestibular ganglion morphology J:199588
absent cochlear hair cells J:199588
cochlear ganglion degeneration J:199588
decreased cochlea coiling J:199588
decreased cochlear hair cell number J:199588
decreased organ of Corti supporting cell number J:199588
increased apoptosis J:199588
inner ear hypoplasia J:199588
neonatal lethality, complete penetrance J:199588
Gata3tm1.1Mbu/Gata3tm1.1Mbu
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal humoral immune response J:123631
decreased interleukin-4 secretion J:123631
increased interferon-gamma secretion J:123631
Gata3tm1.2Mbu/Gata3tm1.2Mbu
C3.129P2-Gata3tm1.2Mbu 		abnormal mesonephros morphology J:104408
abnormal Wolffian duct morphology J:104408
absent ureteric bud J:104408
absent Wolffian ducts J:104408
embryonic lethality during organogenesis, complete penetrance J:104408
Gata3tm1Gsv/Gata3+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal axon guidance J:66227
abnormal sensory neuron innervation pattern J:66227
Gata3tm1Gsv/Gata3+
FVB.129(B6)-Gata3tm1Gsv 		abnormal cochlear outer hair cell morphology J:104653
absent distortion product otoacoustic emissions J:104653
cochlear outer hair cell degeneration J:104653
Gata3tm1Gsv/Gata3+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		cochlear hair cell degeneration J:116235
cochlear inner hair cell degeneration J:116235
cochlear outer hair cell degeneration J:116235
degeneration of organ of Corti supporting cells J:116235
increased or absent threshold for auditory brainstem response J:116235
organ of Corti degeneration J:116235
pillar cell degeneration J:116235
sensorineural hearing loss J:116235
Gata3tm1Gsv/Gata3tm1Gsv
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal aortic arch morphology J:144855
abnormal aorticopulmonary septum morphology J:144855
abnormal axon guidance J:66227
abnormal cardiac outflow tract development J:144855
abnormal cochlear sensory epithelium morphology J:66227
abnormal conotruncal ridge morphology J:144855
abnormal endolymphatic duct morphology J:66227
abnormal facial morphology J:144855
abnormal first pharyngeal arch artery morphology J:144855
abnormal first pharyngeal arch morphology J:144855
abnormal heart morphology J:144855
abnormal heart tube morphology J:144855
abnormal inner ear morphology J:66227
abnormal mandible morphology J:144855
abnormal otic vesicle development J:66227
abnormal pharyngeal arch artery morphology J:144855
abnormal pharynx morphology J:144855
abnormal second pharyngeal arch artery morphology J:144855
abnormal sensory neuron innervation pattern J:66227
absent common crus J:66227
absent semicircular canals J:66227
absent utricle J:66227
absent vestibular saccule J:66227
cervical aortic arch J:144855
decreased cochlea coiling J:66227
delayed inner ear development J:66227, J:93820
double outlet right ventricle J:144855
embryonic lethality during organogenesis, complete penetrance J:66227, J:144855
hemorrhage J:144855
inner ear cyst J:66227
interrupted aortic arch J:144855
persistent truncus arteriosus J:144855
pharyngeal arch hypoplasia J:144855
small otic vesicle J:66227
ventricular septal defect J:144855
Gata3tm1Gsv/Gata3tm1Gsv
involves: 129 		abnormal pyloric sphincter morphology J:228275
abnormal stomach smooth muscle circular layer morphology J:228275
abnormal stomach smooth muscle outer longitudinal layer morphology J:228275
Gata3tm1Gsv/Gata3tm1Gsv
involves: 129 * FVB 		abnormal facial nerve morphology J:310312
abnormal first pharyngeal arch morphology J:310312
abnormal gonial bone morphology J:310312
abnormal incus morphology J:310312
abnormal jaw morphology J:310312
abnormal malleus morphology J:310312
abnormal mandible morphology J:310312
abnormal Meckel's cartilage morphology J:310312
abnormal middle ear ossicle morphology J:310312
abnormal molar morphology J:310312
abnormal neural crest cell migration J:310312
abnormal oral cavity morphology J:310312
abnormal secondary palate development J:310312
abnormal stapes morphology J:310312
abnormal tympanic ring morphology J:310312
absent temporomandibular joint J:310312
bony syngnathia J:310312
cleft palate J:310312
decreased mouth size J:310312
hemifacial hypoplasia J:310312
mandible hypoplasia J:310312
maxilla hypoplasia J:310312
micrognathia J:310312
prenatal lethality, complete penetrance J:310312
small lower incisors J:310312
small mandible J:310312
small maxilla J:310312
small trigeminal ganglion J:310312
small zygomatic bone J:310312
tongue hypoplasia J:310312
Gata3tm1Iho/Gata3tm1Iho
Il13tm1(YFP/cre)Lky/Il13+
involves: 129S4/SvJae 		decreased eosinophil cell number J:178986
increased susceptibility to parasitic infection J:178986
Gata3tm1Iho/Gata3tm1Iho
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal T cell differentiation J:86996
decreased CD4-positive, alpha-beta T cell number J:86996
Gata3tm1Iho/Gata3tm1Iho
Tg(Lck-cre)1Cwi/0
involves: BALB/c 		abnormal CD8-positive, alpha-beta T cell number J:86996
abnormal T cell subpopulation ratio J:86996
arrested T cell differentiation J:86996
decreased CD4-positive, alpha-beta T cell number J:86996
decreased double-positive T cell number J:86996
decreased thymocyte number J:86996
increased T cell apoptosis J:86996
prenatal lethality, incomplete penetrance J:86996
small thymus J:86996
Gata3tm1Jeng/Gata3+
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:28393
Gata3tm1Jeng/Gata3tm1Jeng
involves: 129S7/SvEvBrd 		abnormal blood coagulation J:28393
abnormal brain morphology J:28393
abnormal cardiovascular system physiology J:62552
abnormal craniofacial bone morphology J:28393
abnormal definitive hematopoiesis J:28393
abnormal embryonic growth/weight/body size J:28393
abnormal erythrocyte morphology J:28393
abnormal immune system organ morphology J:62552
abnormal neural tube morphology J:28393
prenatal lethality J:28393
Gata3tm1Jfz/Gata3tm1Jfz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:93538
Gata3tm1Jfz/Gata3tm1Jfz
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha beta T cell morphology J:93538
abnormal T cell differentiation J:141145
decreased CD4-positive, alpha-beta T cell number J:141145
decreased interleukin-13 secretion J:172134
Gata3tm1Jfz/Gata3tm1Jfz
Tg(Fev-cre)1Esd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal Raphe nucleus morphology J:165266
decreased serotonin level J:165266
Gata3tm1Jfz/Gata3tm1Jfz
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal mammary gland growth during lactation J:184505
lactation failure J:184505
Gata3tm1Jfz/Gata3tm1Jfz
Tg(Tnfrsf4-cre)1Nik/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:93538
decreased IgE level J:93538
decreased T-helper 2 cell number J:93538
increased susceptibility to parasitic infection J:93538
increased T-helper 1 cell number J:93538
Gata3tm1Jml/Gata3tm1Jml
involves: 129S/SvEv * C57BL/6 		abnormal immune system cell morphology J:37093
Gata3tm2Gsv/Gata3+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal axon guidance J:66227
abnormal sensory neuron innervation pattern J:66227
Gata3tm2Gsv/Gata3tm2Gsv
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal axon guidance J:66227
abnormal cochlear sensory epithelium morphology J:66227
abnormal endolymphatic duct morphology J:66227
abnormal inner ear morphology J:66227
abnormal otic vesicle development J:66227
abnormal sensory neuron innervation pattern J:66227
absent common crus J:66227
absent semicircular canals J:66227
absent utricle J:66227
absent vestibular saccule J:66227
decreased cochlea coiling J:66227
delayed inner ear development J:66227
embryonic lethality during organogenesis, complete penetrance J:66227
inner ear cyst J:66227
small otic vesicle J:66227
Gata3tm2Jeng/Gata3tm2Jeng
Not Specified 		abnormal double-positive T cell morphology J:155686
abnormal T cell differentiation J:155686
abnormal T cell number J:155686
decreased double-negative T cell number J:155686
decreased gamma-delta T cell number J:155686
decreased thymocyte number J:155686
perinatal lethality J:155686
Gata3tm3Gsv/Gata3tm3Gsv
Tg(Dbh-cre/ERT2)198.1Hroh/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal sympathetic ganglion morphology J:163233
abnormal sympathetic neuron innervation pattern J:163233
blepharoptosis J:163233
normal endocrine/exocrine gland phenotype J:163233
small superior cervical ganglion J:163233
Gata3tm3Gsv/Gata3tm3Gsv
Tg(Dbh-icre)1Gsc/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal embryo development J:163233
abnormal nervous system development J:163233
abnormal sympathetic ganglion morphology J:163233
Gata3tm3Gsv/Gata3tm3Gsv
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		abnormal epidermal layer morphology J:117058
abnormal epidermis stratum basale morphology J:117058
abnormal hair cycle J:117058
abnormal hair follicle inner root sheath morphology J:117058
abnormal hair follicle melanin granule morphology J:117058
abnormal hair follicle morphology J:117058
abnormal hair follicle orientation J:117058
abnormal hair follicle outer root sheath morphology J:117058
abnormal hair growth J:117058
abnormal hair texture J:117058
abnormal skin condition J:117058
abnormal skin morphology J:117058
absent nipple J:117058
absent subcutaneous adipose tissue J:117058
decreased body size J:117058
decreased T cell number J:117058
delayed hair appearance J:117058
enlarged sebaceous gland J:117058
epidermal hyperplasia J:117058
hyperkeratosis J:117058
impaired skin barrier function J:117058
narrow eye opening J:117058
postnatal growth retardation J:117058
progressive hair loss J:117058
scaly skin J:117058
short hair J:117058
short vibrissae J:117058
sparse hair J:117058
thick epidermis J:117058
thick hair follicle outer root sheath J:117058
thin dermal layer J:117058
weight loss J:117058
wrinkled skin J:117058
Gt(ROSA)26Sortm11(Gata3)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA 		normal mortality/aging J:194078
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory