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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gata4
GATA binding protein 4
MGI:95664
141 phenotypes from 14 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gata4em1Vigr/Gata4em1Vigr
involves: C3H/HeJ * C57BL/6J 		normal reproductive system phenotype J:308912
Gata4Tg(Tyr)2265AOve/Gata4Tg(Tyr)2265AOve
FVB/N-Gata4Tg(Tyr)2265AOve 		embryonic lethality between somite formation and embryo turning, complete penetrance J:175597
Gata4tm1(cre)Svs/Gata4+
Tg(Sox3-GFP,Tyr)HolNpln/Tg(Sox3-GFP,Tyr)HolNpln
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal enteric neural crest cell migration J:229828
decreased neuronal precursor cell number J:229828
Gata4tm1.1Jmol/Gata4tm1.1Jmol
involves: 129 * C57BL/6 		abnormal heart ventricle morphology J:174537
abnormal response of heart to induced stress J:174537
decreased circulating testosterone level J:308912
decreased response of heart to induced stress J:174537
decreased seminal vesicle weight J:308912
Gata4tm1.1Sad/Gata4tm1.1Sad
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J 		abnormal ovary physiology J:173711
abnormal seminiferous tubule epithelium morphology J:169018
abnormal Sertoli cell barrier function J:169018
abnormal Sertoli cell morphology J:169018
abnormal spermatid morphology J:169018
abnormal spermatogenesis J:169018
asthenozoospermia J:169018
decreased circulating anti-Mullerian hormone level J:173711
decreased litter size J:173711
decreased male germ cell number J:169018
decreased sperm progressive motility J:169018
decreased superovulation rate J:173711
decreased testis weight J:169018
failure of superovulation J:173711
female infertility J:173711
normal homeostasis/metabolism phenotype J:169018
increased male germ cell apoptosis J:169018
multinucleated giant male germ cells J:169018
oligozoospermia J:169018
ovarian follicular cyst J:173711
ovary cyst J:173711
reduced female fertility J:173711
reduced male fertility J:169018
normal reproductive system phenotype J:169018, J:173711
seminiferous tubule degeneration J:169018
small ovary J:173711
small testis J:169018
testicular atrophy J:169018
Gata4tm1.1Sad/Gata4tm1.1Sad
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		increased cardiomyocyte apoptosis J:121367
prenatal lethality, complete penetrance J:121367
thin ventricular wall J:121367
Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-cre)1Jmk/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal myocardial fiber morphology J:121367
decreased cardiac muscle contractility J:121367
dilated heart J:121367
pulmonary edema J:121367
Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh7-cre)1Jmk/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal heart ventricle morphology J:121367
abnormal myocardial fiber morphology J:121367
cardiac hypertrophy J:121367
decreased cardiac muscle contractility J:121367
dilated heart J:121367
dilated heart left ventricle J:121367
increased cardiomyocyte apoptosis J:121367
premature death J:121367
pulmonary edema J:121367
Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Tek-cre)1Ywa/?
involves: 129S1/Sv * 129X1/SvJ * CD-1 		normal cardiovascular system phenotype J:92434
Gata4tm1.1Sad/Gata4tm1.2Sad
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal muscle phenotype J:231793
Gata4tm1.1Sad/Gata4tm1.2Sad
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J 		abnormal diaphragm development J:231793
abnormal lung lobe morphology J:231793
abnormal lung volume J:231793
abnormal muscle precursor cell morphology J:231793
abnormal muscle precursor cell physiology J:231793
decreased blood oxygen saturation level J:231793
diaphragmatic hernia J:231793
neonatal lethality J:231793
Gata4tm1.1Sho/Gata4tm1.1Sho
involves: 129S6/SvEvTac 		abnormal cardiovascular system morphology J:77392
embryonic lethality during organogenesis, complete penetrance J:77392
Gata4tm1.1Wtp/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd 		abnormal cardiac epithelial to mesenchymal transition J:99203
abnormal fetal cardiomyocyte proliferation J:99203
atrioventricular cushion hypoplasia J:99203
common ventricle J:99203
conotruncal ridge hypoplasia J:99203
embryonic growth retardation J:99203
heart hypoplasia J:99203
heart right ventricle hypoplasia J:99203
lethality throughout fetal growth and development, complete penetrance J:99203
pericardial effusion J:99203
Gata4tm1.1Wtp/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		abnormal fetal cardiomyocyte proliferation J:99203
double outlet right ventricle J:99203
heart hypoplasia J:99203
lethality throughout fetal growth and development, complete penetrance J:99203
Gata4tm1.2Wtp/Gata4+
B6.Cg-Gata4tm1.2Wtp 		abnormal diaphragm central tendon morphology J:117367
abnormal endometrium morphology J:173711
abnormal heart morphology J:117367
abnormal lung morphology J:117367
abnormal lung saccule morphology J:117367
abnormal lung vasculature morphology J:117367
abnormal ovary physiology J:173711
atrioventricular septal defect J:117367
decreased circulating estradiol level J:173711
decreased ovary weight J:173711
decreased superovulation rate J:173711
decreased uterus weight J:173711
delayed estrous cycle J:173711
delayed sexual maturation J:173711
diaphragmatic hernia J:117367
dilated respiratory conducting tube J:117367
increased apoptosis J:117367
neonatal lethality, incomplete penetrance J:117367
normal reproductive system phenotype J:173711
small ovary J:173711
ventricular septal defect J:117367
Gata4tm1.2Wtp/Gata4tm1.2Wtp
involves: 129 * C57BL/6 		abnormal dorsal-ventral axis patterning J:94637
lethality throughout fetal growth and development, complete penetrance J:94637
Gata4tm1Eno/Gata4+
B6.129S7-Gata4tm1Eno 		diaphragmatic hernia J:187416
Gata4tm1Eno/Gata4tm1Eno
involves: 129S7/SvEvBrd * C57BL/6 		abnormal developmental patterning J:40145
abnormal dorsal-ventral axis patterning J:40145
abnormal extraembryonic coelom morphology J:40145
abnormal heart development J:40145
abnormal heart tube morphology J:40145
abnormal neural tube morphology J:40145
absent foregut J:40145
cardia bifida J:40145
decreased embryo size J:40145
embryonic growth arrest J:40145
embryonic growth retardation J:40145
embryonic lethality, complete penetrance J:40145
failure to gastrulate J:40145
Gata4tm1Grg/Gata4+
involves: 129 * C57BL/6 		abnormal heart atrium morphology J:185124
aorta stenosis J:185124
atrial septal defect J:185124
decreased fetal cardiomyocyte proliferation J:185124
patent cardiac foramen ovale J:185124
pulmonary valve stenosis J:185124
thick aortic valve cusps J:185124
thick pulmonary valve cusps J:185124
thin ventricle myocardium compact layer J:185124
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
involves: 129 * C57BL/6 * FVB/N 		no abnormal phenotype detected J:185124
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0
involves: 129 * C57BL/6 		embryonic growth retardation J:185124
embryonic lethality during organogenesis, incomplete penetrance J:185124
thin myocardium J:185124
Gata4tm1Grg/Gata4tm1.1Wtp
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL 		abnormal atrioventricular cushion morphology J:185124
normal growth/size/body region phenotype J:185124
Gata4tm1Grg/Gata4tm1Grg
involves: 129 * C57BL/6 		decreased fetal cardiomyocyte proliferation J:185124
delayed heart looping J:185124
embryonic growth retardation J:185124
embryonic lethality during organogenesis, complete penetrance J:185124
thin myocardium J:185124
thin ventricular wall J:185124
Gata4tm1Jml/Gata4tm1Jml
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		abnormal dorsal-ventral axis patterning J:40144
abnormal foregut morphology J:40144
abnormal heart development J:40144
abnormal rostral-caudal axis patterning J:40144
abnormal visceral yolk sac morphology J:40144
absent heart tube J:40144
decreased embryo size J:40144
Gata4tm1Sho/Gata4+
C57BL/6JEi-Chr YA/HeJ/EiJ 		primary sex reversal J:125196
true hermaphroditism J:125196
Gata4tm1Sho/Gata4+
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac 		normal cardiovascular system phenotype J:150452
Gata4tm1Sho/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		normal cardiovascular system phenotype J:150452
Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal atrioventricular cushion morphology J:150452
abnormal coronary vessel morphology J:150452
hemorrhage J:150452
skin edema J:150452
thin myocardium compact layer J:150452
ventricular septal defect J:150452
Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal cardiovascular system physiology J:150452
dilated heart ventricle J:150452
Gata4tm1Sho/Gata4tm1Sho
involves: 129S6/SvEvTac 		abnormal conotruncal ridge morphology J:77392
abnormal fetal Leydig cell differentiation J:78688
abnormal heart development J:77392
abnormal heart ventricle morphology J:77392
abnormal lung development J:134027
abnormal primary sex determination J:78688
abnormal Sertoli cell morphology J:78688
abnormal truncus arteriosus septation J:77392
absent coronary vessels J:77392
atrial septal defect J:77392
common atrioventricular valve J:77392
common ventricle J:77392
dilated heart atrium J:77392
double outlet right ventricle J:77392
edema J:77392
embryonic lethality during organogenesis, complete penetrance J:77392
hemorrhage J:77392
pallor J:77392
primary sex reversal J:78688
thin myocardium J:77392
ventricular septal defect J:77392
Gata4tm1Wtp/Gata4tm1Wtp
involves: 129 * C57BL/6 		abnormal heart development J:94637
abnormal interventricular septum morphology J:94637
abnormal myocardium compact layer morphology J:94637
atrioventricular valve regurgitation J:94637
complete atrioventricular septal defect J:94637
decreased fetal cardiomyocyte proliferation J:94637
dilated heart right atrium J:94637
double outlet right ventricle J:94637
hydrops fetalis J:94637
lethality throughout fetal growth and development, complete penetrance J:94637
myocardial trabeculae hypoplasia J:94637
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory