Gdf6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gdf6
growth differentiation factor 6
MGI:95689

37 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdf6^{em1(IMPC)Ccpcz}/Gdf6⁺ C57BL/6NCrl-Gdf6^{em1(IMPC)Ccpcz}/Ccpcz	abnormal brain morphology	J:211773
	abnormal digit morphology	J:211773
	abnormal optic disk morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	hydrocephaly	J:211773
	increased lung tissue damping	J:211773
Gdf6^{em1(IMPC)Ccpcz}/Gdf6^{em1(IMPC)Ccpcz} C57BL/6NCrl-Gdf6^{em1(IMPC)Ccpcz}/Ccpcz	preweaning lethality, complete penetrance	J:211773
Gdf6^tm1Kng/Gdf6^tm1Kng involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal articular cartilage morphology	J:83132
	abnormal carpal bone morphology	J:83132
	abnormal incudomalleolar joint morphology	J:83132
	abnormal incudostapedial joint morphology	J:83132
	abnormal incus morphology	J:83132
	abnormal malleus morphology	J:83132
	abnormal middle ear ossicle morphology	J:83132
	abnormal stapes annular ligament morphology	J:83132
	abnormal stapes morphology	J:83132
	abnormal tarsal bone morphology	J:83132
	absent coronal suture	J:83132
	absent stapes annular ligament	J:83132
	fused carpal bones	J:83132
	fused joints	J:83132
	fused tarsal bones	J:83132
	postnatal lethality, incomplete penetrance	J:83132
	small incus	J:83132
	small malleus	J:83132
	small middle ear ossicles	J:83132
	small stapes	J:83132
Gdf6^tm1Lex/Gdf6^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal hearing physiology	J:103485
	abnormal optic disk morphology	J:103485
	abnormal skeleton morphology	J:103485
	decreased body weight	J:103485
	postnatal growth retardation	J:103485
	postnatal lethality	J:103485

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24