Gdf6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gdf6
growth differentiation factor 6
MGI:95689

38 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdf6^{em1(IMPC)Ccpcz}/Gdf6⁺ C57BL/6NCrl-Gdf6^{em1(IMPC)Ccpcz}/Ccpcz	abnormal brain morphology	J:211773
	abnormal digit morphology	J:211773
	abnormal optic disk morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	hydrocephaly	J:211773
	increased lung tissue damping	J:211773
Gdf6^{em1(IMPC)Ccpcz}/Gdf6^{em1(IMPC)Ccpcz} C57BL/6NCrl-Gdf6^{em1(IMPC)Ccpcz}/Ccpcz	no spontaneous movement	J:211773
	preweaning lethality, complete penetrance	J:211773
Gdf6^tm1Kng/Gdf6^tm1Kng involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal articular cartilage morphology	J:83132
	abnormal carpal bone morphology	J:83132
	abnormal incudomalleolar joint morphology	J:83132
	abnormal incudostapedial joint morphology	J:83132
	abnormal incus morphology	J:83132
	abnormal malleus morphology	J:83132
	abnormal middle ear ossicle morphology	J:83132
	abnormal stapes annular ligament morphology	J:83132
	abnormal stapes morphology	J:83132
	abnormal tarsal bone morphology	J:83132
	absent coronal suture	J:83132
	absent stapes annular ligament	J:83132
	fused carpal bones	J:83132
	fused joints	J:83132
	fused tarsal bones	J:83132
	postnatal lethality, incomplete penetrance	J:83132
	small incus	J:83132
	small malleus	J:83132
	small middle ear ossicles	J:83132
	small stapes	J:83132
Gdf6^tm1Lex/Gdf6^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal hearing physiology	J:103485
	abnormal optic disk morphology	J:103485
	abnormal skeleton morphology	J:103485
	decreased body weight	J:103485
	postnatal growth retardation	J:103485
	postnatal lethality	J:103485

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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